日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly Z-Selective Double Bond Transposition in Simple Alkenes and Allylarenes through a Spin-Accelerated Allyl Mechanism

通过自旋加速烯丙基机制在简单烯烃和烯丙基芳烃中实现高Z选择性双键转位

Kim, Daniel; Pillon, Guy; DiPrimio, Daniel J; Holland, Patrick L

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

将醛糖还原酶抑制剂和糖尿病神经病变药物依帕司他重新用于治疗先天性糖基化障碍 PMM2-CDG

Sangeetha Iyer, Feba S Sam, Nina DiPrimio, Graeme Preston, Jan Verheijen, Kausalya Murthy, Zachary Parton, Hillary Tsang, Jessica Lao, Eva Morava, Ethan O Perlstein

Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches

在蠕虫和果蝇模型中对NGLY1缺陷进行药物筛选,揭示了儿茶酚胺、NRF2和抗炎通路激活是潜在的临床治疗方法。

Iyer, Sangeetha; Mast, Joshua D; Tsang, Hillary; Rodriguez, Tamy P; DiPrimio, Nina; Prangley, Madeleine; Sam, Feba S; Parton, Zachary; Perlstein, Ethan O

Yeast Models of Phosphomannomutase 2 Deficiency, a Congenital Disorder of Glycosylation

磷酸甘露糖变位酶 2 缺乏症(一种先天性糖基化障碍)的酵母模型

Jessica P Lao, Nina DiPrimio, Madeleine Prangley, Feba S Sam, Joshua D Mast, Ethan O Perlstein

GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts

GEX1A 是一种来自色褐链霉菌的聚酮化合物,可纠正人类成纤维细胞中与尼曼-匹克 C1 型相关的细胞缺陷

Eve A Granatosky, Nina DiPrimio, Jarred R E Pickering, D Cole Stevens, Ethan O Perlstein, Richard E Taylor

The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation

通过化学方法挽救蛋白质结构来设计蛋白质开关:失活和再激活机制

Xia, Yan; DiPrimio, Nina; Keppel, Theodore R; Vo, Binh; Fraser, Keith; Battaile, Kevin P; Egan, Chet; Bystroff, Christopher; Lovell, Scott; Weis, David D; Anderson, J Christopher; Karanicolas, John

Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles

腺相关病毒衣壳的单个氨基酸修饰会改变其转导和体液免疫谱。

Li, Chengwen; Diprimio, Nina; Bowles, Dawn E; Hirsch, Matthew L; Monahan, Paul E; Asokan, Aravind; Rabinowitz, Joseph; Agbandje-McKenna, Mavis; Samulski, R Jude

Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

通过对腺相关病毒受体足迹进行重新设计,可以实现对肌肉的选择性和系统性基因转移。

Asokan, Aravind; Conway, Julia C; Phillips, Jana L; Li, Chengwen; Hegge, Julia; Sinnott, Rebecca; Yadav, Swati; DiPrimio, Nina; Nam, Hyun-Joo; Agbandje-McKenna, Mavis; McPhee, Scott; Wolff, Jon; Samulski, R Jude

Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction

腺相关病毒 2 型衣壳蛋白 VP1 的诱变揭示了碱性氨基酸在运输和细胞特异性转导中的新作用

Jarrod S Johnson, Chengwen Li, Nina DiPrimio, Marc S Weinberg, Thomas J McCown, R Jude Samulski

Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles

重组AAV基因组的工程改造与筛选:一种生产靶向生物纳米颗粒的新策略

Li, Wuping; Asokan, Aravind; Wu, Zhijian; Van Dyke, Terry; DiPrimio, Nina; Johnson, Jarrod S; Govindaswamy, Lakshmanan; Agbandje-McKenna, Mavis; Leichtle, Stefan; Redmond, D Eugene Jr; McCown, Thomas J; Petermann, Kimberly B; Sharpless, Norman E; Samulski, Richard J