日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian-Human Immunodeficiency Virus

每周口服MK-8527进行预防可保护恒河猴免受猴-人免疫缺陷病毒直肠内感染

Diamond, Tracy L; Kapoor, Yash; Li, Fangbiao; Wan, Bang-Lin; Boddicker, Melissa A; Maxwell, Jill W; Ngo, Winnie; Fontenot, Jane A; Soileau, Kelly A; Villinger, Francois J; Grobler, Jay A; Wang, Shubing; Fillgrove, Kerry L; Lange, Henry S; Asante-Appiah, Ernest

MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing

MK-8527 是一种新型的 HIV-1 逆转录酶易位抑制剂,具有延长给药时间的潜力。

Raheem, Izzat T; Girijavallabhan, Vinay; Fillgrove, Kerry L; Goh, Shih Lin; Bahnck-Teets, Carolyn; Huang, Qian; Li, Fangbiao; Wan, Bang-Lin; O'Donnell, Gregory T; Patteson, Jonathan B; Cilento, Maria E; Bennet, Amrith; Hayes, Robert P; Tummala, Srivanya; McHale, Carolyn; Wiltsie, Judyann; Ellis, Joan; Asante-Appiah, Ernest; Hazuda, Daria J; Hale, Jeffrey; Grobler, Jay A; Xu, Min; Diamond, Tracy L; Lai, Ming-Tain

Effectiveness of islatravir post-exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques

伊斯拉曲韦在恒河猴静脉注射猴免疫缺陷病毒后进行暴露后预防的有效性

Markowitz, Martin; Gettie, Agegnehu; St Bernard, Leslie; Grasperge, Brooke; Vargo, Ryan; Pham, Michelle; Fillgrove, Kerry; Dube, Neal; Diamond, Tracy L; Hazuda, Daria J; Grobler, Jay A

No antagonism or cross-resistance and a high barrier to the emergence of resistance in vitro for the combination of islatravir and lenacapavir

伊斯拉曲韦和来那卡帕韦联合用药在体外无拮抗作用或交叉耐药性,且耐药性产生屏障较高。

Diamond, Tracy L; Goh, Shih Lin; Ngo, Winnie; Rodriguez, Silveria; Xu, Min; Klein, Daniel J; Grobler, Jay A; Asante-Appiah, Ernest

Cytomegalovirus Antiviral Resistance Among Kidney Transplant Recipients in a Phase 3 Trial of Letermovir vs Valganciclovir Prophylaxis

在来特莫韦与缬更昔洛韦预防的3期临床试验中,肾移植受者中巨细胞病毒抗病毒耐药性

Strizki, Julie M; Diamond, Tracy L; Teal, Valerie L; Gilbert, Christopher L; Wang, Weiwen; Stauffer, Nicole; Haber, Barbara A

Discovery of [(11)C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR(2) Negative Allosteric Modulators

[(11)C]MK-8056 的发现:一种用于研究 mGluR(2) 负变构调节剂的选择性 PET 成像剂

Perkins, James J; McQuade, Paul; Bungard, Christopher J; Diamond, Tracy L; Gantert, Liza T; Gotter, Anthony L; Hanney, Barbara; Hills, Ivory D; Hurzy, Danielle M; Joshi, Aniket; Kern, Jonathan T; Schlegel, Kelly-Ann S; Manikowski, Jesse J; Meng, Zhaoyang; O'Brien, Julie A; Roecker, Anthony J; Smith, Sean M; Uslaner, Jason M; Hostetler, Eric; Meissner, Robert S

Doravirine and Islatravir Have Complementary Resistance Profiles and Create a Combination with a High Barrier to Resistance

多拉韦林和伊斯拉曲韦具有互补的耐药谱,二者联合使用可形成高耐药屏障。

Lai, Ming-Tain; Feng, Meizhen; Xu, Min; Ngo, Winnie; Diamond, Tracy L; Hwang, Carey; Grobler, Jay A; Hazuda, Daria J; Asante-Appiah, Ernest

Islatravir Has a High Barrier to Resistance and Exhibits a Differentiated Resistance Profile from Approved Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

伊斯拉曲韦具有较高的耐药屏障,并且与已批准的核苷类逆转录酶抑制剂(NRTIs)表现出不同的耐药性特征。

Diamond, Tracy L; Ngo, Winnie; Xu, Min; Goh, Shih Lin; Rodriguez, Silveria; Lai, Ming-Tain; Asante-Appiah, Ernest; Grobler, Jay A

Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

HIV整合酶的结构特性晶状体上皮衍生生长因子寡聚体

Gupta Kushol, Diamond Tracy, Hwang Young, Bushman Frederic, Van Duyne Gregory D

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase.

HIV-1 对巨噬细胞的嗜性取决于逆转录酶对细胞内 dNTP 的有效利用

Diamond Tracy L, Roshal Mikhail, Jamburuthugoda Varuni K, Reynolds Holly M, Merriam Aaron R, Lee Kwi Y, Balakrishnan Mini, Bambara Robert A, Planelles Vicente, Dewhurst Stephen, Kim Baek