日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1

原花青素通过稳定 LKB1 和 SYVN1 促进泛素-蛋白酶体途径降解 PD-L1，从而增强抗肿瘤免疫力。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI197592
Xu, Mengting; Lin, Xuwen; Xu, Hanchi; Hu, Hongmei; Xue, Xinying; Zhang, Qing; Yu, Dianping; Tian, Saisai; Xie, Mei; Li, Linyang; Tao, Xiaoyu; Li, Xinru; Li, Simeng; Xie, Shize; Tian, Yating; Liu, Xia; Xu, Hanchen; Wang, Qun; Zhang, Weidong; Liu, Sanhong
PD-L1
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2026
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Paroxetine repurposing enhances antitumor immunity via SPOP-mediated PD-L1 ubiquitination and proteasomal degradation

帕罗西汀的重新定位通过SPOP介导的PD-L1泛素化和蛋白酶体降解增强抗肿瘤免疫力。

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-026-03648-z
Xu, Mengting; Tian, Saisai; Xu, Hanchi; Xue, Xinying; Zhang, Qing; Hu, Hongmei; Wu, Gaosong; Geng, Xiangxin; Yu, Dianping; Xu, Hanchen; Xie, Mei; Li, Linyang; Li, Xinru; Li, Simeng; Xie, Shize; Lin, Xuwen; Lyu, Shuzhen; Xie, Yutong; Zhang, Biao; Zhou, Haiyang; Wang, Qun; Zhang, Weidong; Liu, Sanhong
肿瘤
表观遗传
肿瘤免疫
泛素化
SPOP
PD-L1
免疫/内分泌
发表日期：2026
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Tuning the anisotropic facet of Cu(2)O single-crystals for photocarrier spatial segregation

调控Cu(2)O单晶的各向异性晶面以实现光载流子的空间分离

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d5sc07288c
Tian, Shuo; Wang, Yunsen; Chen, Shuyun; Yu, Zhichao; Wu, Di; Qin, Jiao; Tang, Dianyong; Tang, Dianping
信号转导
发表日期：2026
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Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer

乙酰伐特作为一种新型铁死亡诱导剂，在结直肠癌中具有PCBP1/2和GPX4双重靶点作用。

期刊:Signal Transduction and Targeted Therapy
影响因子:52.7
doi:10.1038/s41392-025-02296-7
Yu, Dianping; Hu, Hongmei; Zhang, Qing; Wang, Chengji; Xu, Mengting; Xu, Hanchen; Geng, Xiangxin; Cai, Minchen; Zhang, Hongwei; Guo, Mengmeng; Lu, Dong; Xu, Hanchi; Li, Linyang; Zhang, Xing; Shen, Ruling; Lin, Sheng; Wang, Qun; Zhang, Weidong; Liu, Sanhong
肿瘤
肠癌
肿瘤免疫
CBP
铁死亡
GPX4
发表日期：2025
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Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1

海洋天然产物查戈森定C通过靶向FDX1诱导结直肠癌细胞凋亡

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c07917
Tao, Xiaoyu; Wang, Hongru; Wang, Qun; Wang, Chengji; Shao, Chang-Wei; Jin, Yang; Yu, Dianping; Hu, Hongmei; Zhang, Qing; Xu, Mengting; Geng, Xiangxin; Xu, Hanchi; Li, Linyang; Shen, Ruling; Guo, Yue-Wei; Li, Xu-Wen; Liu, Sanhong; Zhang, Weidong
肿瘤
肠癌
表观遗传
肿瘤免疫
凋亡
细胞生物学
发表日期：2025
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Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer

基于网络医学的策略发现，马普替林可通过靶向SPOP抑制PD-L1表达，从而成为一种可重新利用的药物。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202410285
Tian, Saisai; Xu, Mengting; Geng, Xiangxin; Fang, Jiansong; Xu, Hanchen; Xue, Xinying; Hu, Hongmei; Zhang, Qing; Yu, Dianping; Guo, Mengmeng; Zhang, Hongwei; Lu, Jinyuan; Guo, Chengyang; Wang, Qun; Liu, Sanhong; Zhang, Weidong
PD-L1
SPOP
发表日期：2025
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Cordycepin Targets HRD1 to Promote Cancer Cell PD-L1 Ubiquitin-Proteasome Degradation and Increase Antitumor Immunity

虫草素靶向HRD1促进癌细胞PD-L1泛素-蛋白酶体降解并增强抗肿瘤免疫力

期刊:MedComm
影响因子:10.7
doi:10.1002/mco2.70430
Geng, Xiangxin; Cai, Minchen; Hu, Hongmei; Xu, Mengting; Zhang, Qing; Xu, Hanchen; Yu, Dianping; Zhang, Hongwei; Xu, Hanchi; Li, Linyang; Guo, Mengmeng; Xie, Shize; Wang, Qun; Zhang, Weidong; Liu, Sanhong
肿瘤
肿瘤免疫
PD-L1
细胞生物学
免疫/内分泌
发表日期：2025
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Population pharmacokinetics and clinical assessment of linezolid in pediatric bacterial infections

利奈唑胺在儿童细菌感染中的群体药代动力学和临床评估

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.01299-24
Tian, Xue; Jiang, Tingting; Dong, Lei; Zhang, Xinfang; Jiao, Weiwei; Liu, Gang; Li, Qinjing; Bi, Jing; You, Dianping; Cao, Ling; Guo, Wenhui; Jin, Zhipeng; Zhang, Qunqun; Xu, Yongsheng; Zhao, Wei; Qi, Hui; Zheng, Yi; Shen, Adong
炎症/感染
微生物学
发表日期：2025
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Establishment and analysis of the prediction model for the prognosis of children with sepsis based on pSOFA score

基于pSOFA评分建立和分析脓毒症患儿预后预测模型

期刊:Pakistan Journal of Medical Sciences
影响因子:1.7
doi:10.12669/pjms.41.4.10001
Guo, Fang; Qu, Yi; Kang, Lei; Xu, Meixian; Ma, Li; Li, Wenhui; You, Dianping
炎症/感染
败血症
发表日期：2025
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Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22

去甲基泽拉甾醇通过靶向USP22诱导PD-L1泛素-蛋白酶体降解并促进抗肿瘤免疫

期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2024.08.004
Zhang, Yanyan; Huang, Yun; Yu, Dianping; Xu, Mengting; Hu, Hongmei; Zhang, Qing; Cai, Minchen; Geng, Xiangxin; Zhang, Hongwei; Xia, Jianhua; Guo, Mengmeng; Lu, Dong; Xu, Hanchi; Li, Linyang; Zhang, Xing; Wang, Qun; Liu, Sanhong; Zhang, Weidong
PD-L1
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2024
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