日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The structural diversity of psychedelic drug actions revealed

迷幻药作用的结构多样性揭示

Gumpper, Ryan H; Jain, Manish K; Kim, Kuglae; Sun, Renhong; Sun, Ning; Xu, Zhongli; DiBerto, Jeffrey F; Krumm, Brian E; Kapolka, Nicholas J; Kaniskan, H Ümit; Nichols, David E; Jin, Jian; Fay, Jonathan F; Roth, Bryan L

AlphaFold2 structures guide prospective ligand discovery

AlphaFold2结构指导潜在配体的发现

Lyu, Jiankun; Kapolka, Nicholas; Gumpper, Ryan; Alon, Assaf; Wang, Liang; Jain, Manish K; Barros-Álvarez, Ximena; Sakamoto, Kensuke; Kim, Yoojoong; DiBerto, Jeffrey; Kim, Kuglae; Glenn, Isabella S; Tummino, Tia A; Huang, Sijie; Irwin, John J; Tarkhanova, Olga O; Moroz, Yurii; Skiniotis, Georgios; Kruse, Andrew C; Shoichet, Brian K; Roth, Bryan L

Structure-guided design of a peripherally restricted chemogenetic system.

结构导向的外周限制性化学遗传系统设计

Kang Hye Jin, Krumm Brian E, Tassou Adrien, Geron Matan, DiBerto Jeffrey F, Kapolka Nicholas J, Gumpper Ryan H, Sakamoto Kensuke, Dewran Kocak D, Olsen Reid H J, Huang Xi-Ping, Zhang Shicheng, Huang Karen L, Zaidi Saheem A, Nguyen MyV T, Jo Min Jeong, Katritch Vsevolod, Fay Jonathan F, Scherrer Grégory, Roth Bryan L

Structure-based design of bitopic ligands for the µ-opioid receptor

基于结构的μ-阿片受体双位点配体设计

Faouzi, Abdelfattah; Wang, Haoqing; Zaidi, Saheem A; DiBerto, Jeffrey F; Che, Tao; Qu, Qianhui; Robertson, Michael J; Madasu, Manish K; El Daibani, Amal; Varga, Balazs R; Zhang, Tiffany; Ruiz, Claudia; Liu, Shan; Xu, Jin; Appourchaux, Kevin; Slocum, Samuel T; Eans, Shainnel O; Cameron, Michael D; Al-Hasani, Ream; Pan, Ying Xian; Roth, Bryan L; McLaughlin, Jay P; Skiniotis, Georgios; Katritch, Vsevolod; Kobilka, Brian K; Majumdar, Susruta

Molecular mechanism of biased signaling at the kappa opioid receptor.

kappa阿片受体偏向性信号传导的分子机制

El Daibani Amal, Paggi Joseph M, Kim Kuglae, Laloudakis Yianni D, Popov Petr, Bernhard Sarah M, Krumm Brian E, Olsen Reid H J, Diberto Jeffrey, Carroll F Ivy, Katritch Vsevolod, Wünsch Bernhard, Dror Ron O, Che Tao

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework

利用生成式深度学习框架从头设计κ-阿片受体拮抗剂

Salas-Estrada, Leslie; Provasi, Davide; Qiu, Xing; Kaniskan, Husnu Ümit; Huang, Xi-Ping; DiBerto, Jeffrey F; Lamim Ribeiro, João Marcelo; Jin, Jian; Roth, Bryan L; Filizola, Marta

De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep Learning Framework

利用生成式深度学习框架从头设计κ-阿片受体拮抗剂

Salas-Estrada, Leslie; Provasi, Davide; Qui, Xing; Kaniskan, H Ümit; Huang, Xi-Ping; DiBerto, Jeffrey F; Ribeiro, João Marcelo Lamim; Jin, Jian; Roth, Bryan L; Filizola, Marta

Serotonin modulates an inhibitory input to the central amygdala from the ventral periaqueductal gray

血清素调节来自腹侧导水管周围灰质对中央杏仁核的抑制性输入。

Hon, Olivia J; DiBerto, Jeffrey F; Mazzone, Christopher M; Sugam, Jonathan; Bloodgood, Daniel W; Hardaway, J Andrew; Husain, Mariya; Kendra, Alexis; McCall, Nora M; Lopez, Alberto J; Kash, Thomas L; Lowery-Gionta, Emily G

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

室旁丘脑通过多突触抑制边缘系统促肾上腺皮质激素释放因子(CRF)神经元,以性别依赖的方式减弱小鼠的酗酒和回避行为。

Levine, Olivia B; Skelly, Mary Jane; Miller, John D; Rivera-Irizarry, Jean K; Rowson, Sydney A; DiBerto, Jeffrey F; Rinker, Jennifer A; Thiele, Todd E; Kash, Thomas L; Pleil, Kristen E

Nanobody-enabled monitoring of kappa opioid receptor states

利用纳米抗体监测κ阿片受体状态

Che, Tao; English, Justin; Krumm, Brian E; Kim, Kuglae; Pardon, Els; Olsen, Reid H J; Wang, Sheng; Zhang, Shicheng; Diberto, Jeffrey F; Sciaky, Noah; Carroll, F Ivy; Steyaert, Jan; Wacker, Daniel; Roth, Bryan L