日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

酪氨酸tRNA合成酶的反应劫持作为一种新的全生命周期抗疟策略

Xie, Stanley C; Metcalfe, Riley D; Dunn, Elyse; Morton, Craig J; Huang, Shih-Chung; Puhalovich, Tanya; Du, Yawei; Wittlin, Sergio; Nie, Shuai; Luth, Madeline R; Ma, Liting; Kim, Mi-Sook; Pasaje, Charisse Flerida A; Kumpornsin, Krittikorn; Giannangelo, Carlo; Houghton, Fiona J; Churchyard, Alisje; Famodimu, Mufuliat T; Barry, Daniel C; Gillett, David L; Dey, Sumanta; Kosasih, Clara C; Newman, William; Niles, Jacquin C; Lee, Marcus C S; Baum, Jake; Ottilie, Sabine; Winzeler, Elizabeth A; Creek, Darren J; Williamson, Nicholas; Parker, Michael W; Brand, Stephen; Langston, Steven P; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

设计对恶性疟原虫具有体内口服疗效且对人蛋白酶体具有选择性的蛋白酶体抑制剂

Xie, Stanley C; Metcalfe, Riley D; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J; Cohen, Lawrence H; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E; Barry, Daniel C; Liu, Boyin; Gillett, David L; Crespo-Fernandez, Benigno F; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C; Guido, Rafael V C; Baum, Jake; Hanson, Kirsten K; Winzeler, Elizabeth A; Gamo, Francisco-Javier; Fidock, David A; Baud, Delphine; Parker, Michael W; Brand, Stephen; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

泛素样蛋白偶联和泛素-蛋白酶体系统作为药物靶点

Bedford, Lynn; Lowe, James; Dick, Lawrence R; Mayer, R John; Brownell, James E

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit

对一系列新型非共价蛋白酶体抑制剂进行表征,这些抑制剂对 20S β5 亚基具有极高的效力和选择性。

Blackburn, Christopher; Gigstad, Kenneth M; Hales, Paul; Garcia, Khristofer; Jones, Matthew; Bruzzese, Frank J; Barrett, Cynthia; Liu, Jane X; Soucy, Teresa A; Sappal, Darshan S; Bump, Nancy; Olhava, Edward J; Fleming, Paul; Dick, Lawrence R; Tsu, Christopher; Sintchak, Michael D; Blank, Jonathan L

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

NEDD8 共轭途径及其在癌症生物学和治疗中的意义

Soucy, Teresa A; Dick, Lawrence R; Smith, Peter G; Milhollen, Michael A; Brownell, James E