日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Spatial transcriptional profiling of CHB liver biopsies reveals an undetected population of zonally biased HBV-integrated cells

对慢性乙型肝炎(CHB)肝活检组织进行空间转录组分析,揭示了未被发现的区域性HBV整合细胞群。

Mahadevan, Sangeetha; Ramirez, Ricardo; Mehrabian, Hatef; Moon, Christina; Mohan, Apoorva; Vaquero, Edith; Win, Rosanna; Chaudhuri, Subhra; Chuang, Hsiu-Chun; Sun, Kai-Hui; Aggarwal, Abhishek; Rao, Anjali; Li, Li; Fletcher, Simon P; Balsitis, Scott; Diehl, Lauri; Holdorf, Meghan M

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response.

对免疫热肿瘤和免疫冷肿瘤进行单细胞和空间分析,可以识别与不同免疫微环境和积极免疫治疗反应相关的成纤维细胞亚型

Jenkins Benjamin H, Tracy Ian, Rodrigues Maria Fernanda S D, Smith Melanie J L, Martinez Begoña R, Edmond Mark, Mahadevan Sangeetha, Rao Anjali, Zong Hailing, Liu Kai, Aggarwal Abhishek, Li Li, Diehl Lauri, King Emma V, Bates Jamie G, Hanley Christopher J, Thomas Gareth J

Trop-2 expression in non-small cell lung cancer.

非小细胞肺癌中Trop-2的表达

Kuo Peiwen, Elboudwarej Emon, Zavodovskaya Marianna, Lin Kai-Wen, Lee Chingwei V, Diehl Lauri, Patel Jilpa, Mekan Sabeen, Jürgensmeier Juliane M

Spatial profiling of HPV-stratified head and neck squamous cell carcinoma reveals distinct immune niches and microenvironmental architectures

HPV分层头颈部鳞状细胞癌的空间分析揭示了不同的免疫微环境和微环境结构

Markovits, Ettai; Klymyshyn, Dmytro; Froumine, Roni; Zong, Hailing; Mints, Michael; Mahadevan, Sangeetha; Bloom, Kenneth; Bates, Jamie; Thomas, Gareth J; Diehl, Lauri; Puig, Oscar; Aggarwal, Abhishek

Leveraging immuno-fluorescence data to reduce pathologist annotation requirements in lung tumor segmentation using deep learning

利用免疫荧光数据和深度学习减少肺肿瘤分割中病理学家的标注需求

Mehrabian, Hatef; Brodbeck, Jens; Lyu, Peipei; Vaquero, Edith; Aggarwal, Abhishek; Diehl, Lauri

IL-31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

IL-31 水平与胆汁淤积性和代谢性肝病患者的瘙痒症状相关,并且在非酒精性脂肪性肝炎 (NASH) 中对法尼醇 X 受体有反应。

Xu, Jun; Wang, Ya; Khoshdeli, Mina; Peach, Matt; Chuang, Jen-Chieh; Lin, Julie; Tsai, Wen-Wei; Mahadevan, Sangeetha; Minto, Wesley; Diehl, Lauri; Gupta, Ruchi; Trauner, Michael; Patel, Keyur; Noureddin, Mazen; Kowdley, Kris V; Gulamhusein, Aliya; Bowlus, Christopher L; Huss, Ryan S; Myers, Robert P; Chung, Chuhan; Billin, Andrew N

Intrahepatic quantification of HBV antigens in chronic hepatitis B reveals heterogeneity and treatment-mediated reductions in HBV core-positive cells

慢性乙型肝炎患者肝内HBV抗原定量分析揭示了其异质性,并发现治疗可导致HBV核心阳性细胞减少。

Aggarwal, Abhishek; Odorizzi, Pamela M; Brodbeck, Jens; van Buuren, Nicholas; Moon, Christina; Chang, Silvia; Adona, MaryVic; Suthram, Silpa; Suri, Vithika; Trowe, Torsten; Turner, Scott; Marcellin, Patrick; Buti, Maria; Gaggar, Anuj; Fletcher, Simon P; Diehl, Lauri; Feierbach, Becket; Balsitis, Scott

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer

在RAS驱动的胰腺癌小鼠模型中,KSR1纯合缺失可减轻发病率,但不能阻止肿瘤的发生。

Germino, Elizabeth A; Miller, Joseph P; Diehl, Lauri; Swanson, Carter J; Durinck, Steffen; Modrusan, Zora; Miner, Jeffrey H; Shaw, Andrey S

Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?

树突状细胞在炎症性肠病发病机制中的作用:一个潜在的治疗领域?

Bates, Jennifer; Diehl, Lauri

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

类风湿性关节炎的滑膜表型与生物疗法的疗效相关

Dennis, Glynn Jr; Holweg, Cécile T J; Kummerfeld, Sarah K; Choy, David F; Setiadi, A Francesca; Hackney, Jason A; Haverty, Peter M; Gilbert, Houston; Lin, Wei Yu; Diehl, Lauri; Fischer, S; Song, An; Musselman, David; Klearman, Micki; Gabay, Cem; Kavanaugh, Arthur; Endres, Judith; Fox, David A; Martin, Flavius; Townsend, Michael J