日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma

RHOA 控制侵袭性淋巴瘤中的致癌 B 细胞受体信号传导

Jacobs, Ariana N; Jahn, Dominique; Beringer, Tim; Wolf, Sebastian; Krishnan, Ramesh K; Engelke, Michael; Häupl, Björn; Münch, Silvia; Dienstbier, Niklas; Pape, Martine; Bodach, Marion; Yu, Xin; Serin, Nazli; Wurm-Kuczera, Rebecca; Zindel, Alena; Döbele, Carmen; Chapuy, Björn; Staudt, Louis M; Scheich, Sebastian; Oellerich, Thomas

Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.

C端HSP90二聚化的小分子抑制剂可调节自噬,并与mTOR抑制剂协同作用杀死顺铂耐药癌细胞。

David Céline, Sun Yadong, Woloschin Vitalij, Vogt Melina, Dienstbier Niklas, Friedrich Annabelle, Krings Karina S, Schlütermann David, Berning Lena, Lungerich Beate, Akgün Seda, Mendiburo María José, Gertzen Christoph G W, Borkhardt Arndt, Wesselborg Sebastian, Gohlke Holger, Bhatia Sanil, Kurz Thomas, Stork Björn

Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells.

鉴定出与 RUNX1-ETO 的 NHR2 结构域相互作用的非带电 7.44 类似物,在 RUNX-ETO 阳性细胞中具有增强的抗增殖作用

Gopalswamy Mohanraj, Bickel David, Dienstbier Niklas, Tu Jia-Wey, Vogt Melina, Schott-Verdugo Stephan, Bhatia Sanil, Etzkorn Manuel, Gohlke Holger