日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

一种口服、可渗透大脑的小分子通过增强伪外显子的插入来降低亨廷顿蛋白的水平

Caroline Gubser Keller #, Youngah Shin #, Alex Mas Monteys #, Nicole Renaud, Martin Beibel, Natalia Teider, Thomas Peters, Thomas Faller, Sophie St-Cyr, Judith Knehr, Guglielmo Roma, Alejandro Reyes, Marc Hild, Dmitriy Lukashev, Diethilde Theil, Natalie Dales, Jang-Ho Cha, Beth Borowsky, Ricardo Dol

Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human

小鼠长期接受 S1P 调节剂西泊芬莫德治疗后诱发血管肉瘤,且与大鼠和人类无相关性

Francois Pognan, J Andreas Mahl, Maria Papoutsi, David Ledieu, Marc Raccuglia, Diethilde Theil, Sarah B Voytek, Patrick J Devine, Katie Kubek-Luck, Natalie Claudio, Andre Cordier, Annabelle Heier, Carine Kolly, Andreas Hartmann, Salah-Dine Chibout, Page Bouchard, Christian Trendelenburg

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations

视黄酸孤儿受体C抑制剂可抑制Th17细胞并诱导胸腺异常

Christine Guntermann ,Alessandro Piaia ,Marie-Laure Hamel ,Diethilde Theil ,Tina Rubic-Schneider ,Alberto Del Rio-Espinola ,Linda Dong ,Andreas Billich ,Klemens Kaupmann ,Janet Dawson ,Klemens Hoegenauer ,David Orain ,Samuel Hintermann ,Rowan Stringer ,Dhavalkumar D Patel ,Arno Doelemeyer ,Mark Deurinck ,Jens Schümann

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

药理学 BACE1 和 BACE2 抑制通过抑制小鼠的 PMEL17 处理导致毛发脱色

Derya R Shimshek, Laura H Jacobson, Carine Kolly, Natasa Zamurovic, Kamal Kumar Balavenkatraman, Laurent Morawiec, Robert Kreutzer, Juliane Schelle, Mathias Jucker, Barbara Bertschi, Diethilde Theil, Annabelle Heier, Karine Bigot, Karen Beltz, Rainer Machauer, Irena Brzak, Ludovic Perrot, Ulf Neuman

Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients

干扰素β和维生素D协同诱导多发性硬化症患者外周血单核细胞免疫调节受体

Anne Waschbisch, Nicholas Sanderson, Markus Krumbholz, George Vlad, Diethilde Theil, Stefan Schwab, Mathias Mäurer, Tobias Derfuss

Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection

人类三叉神经节神经元群体的特征及其与潜伏性单纯疱疹病毒 1 型感染的关系

Sarah E Flowerdew, Desiree Wick, Susanne Himmelein, Anja K E Horn, Inga Sinicina, Michael Strupp, Thomas Brandt, Diethilde Theil, Katharina Hüfner

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

LRRK2 蛋白水平由激酶功能决定,对小鼠肾脏和肺脏的稳态至关重要

Martin C Herzig, Carine Kolly, Elke Persohn, Diethilde Theil, Tatjana Schweizer, Thomas Hafner, Christine Stemmelen, Thomas J Troxler, Peter Schmid, Simone Danner, Christian R Schnell, Matthias Mueller, Bernd Kinzel, Armelle Grevot, Federico Bolognani, Martina Stirn, Rainer R Kuhn, Klemens Kaupmann,