日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Comparative Performance of agentic AI and Physicians in Taking Clinical History across Leading Large Language Models (LLMs)

在主流大型语言模型（LLM）中，人工智能代理与医生在采集临床病史方面的性能比较

期刊:
影响因子:
doi:10.64898/2026.01.23.26344723
Steinbuch, Sophie; de Vos-Hillebrand, Luka; O'Neill-Dee, Connor; Wu, Iris; Steinbuch, Hannah; Kulcsár, Zsófi; Ranjan, Avanish; Verma, Ashish; Landsberg, Jennifer; Dietrich, Dimo; Hardin, Charles C; Jain, Rakesh K; Subudhi, Sonu
发表日期：2026
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Feasibility of Monitoring Response to Metastatic Prostate Cancer Treatment with a Methylation-Based Circulating Tumor DNA Approach

利用基于甲基化的循环肿瘤DNA方法监测转移性前列腺癌治疗反应的可行性

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers16030482
Büttner, Thomas; Dietrich, Dimo; Zarbl, Romina; Klümper, Niklas; Ellinger, Jörg; Krausewitz, Philipp; Ritter, Manuel
肿瘤
表观遗传
肿瘤免疫
DNA甲基化
前列腺癌
发表日期：2024
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Hypermethylated SHOX2 in circulating cell-free DNA post renal cell carcinoma surgery as TNM-independent biomarker for recurrence risk

肾细胞癌手术后循环游离DNA中SHOX2高甲基化可作为TNM分期非依赖性复发风险生物标志物。

期刊:American Journal of Translational Research
影响因子:1.6
doi:10.62347/QOBT7285
Büttner, Thomas; Zarbl, Romina; Krausewitz, Philipp; Strieth, Sebastian; Kristiansen, Glen; Eckstein, Markus; Ralser, Damian J; Hölzel, Michael; Ritter, Manuel; Ellinger, Jörg; Dietrich, Dimo; Klümper, Niklas
肿瘤
表观遗传
肿瘤免疫
肾癌
细胞生物学
发表日期：2024
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Clonal Hematopoiesis-Associated Gene Mutations in a Clinical Cohort of 448 Patients With Ovarian Cancer

卵巢癌448例患者临床队列中克隆性造血相关基因突变

期刊:Jnci-Journal of the National Cancer Institute
影响因子:7.2
doi:10.1093/jnci/djab231
Weber-Lassalle, Konstantin; Ernst, Corinna; Reuss, Alexander; Möllenhoff, Kathrin; Baumann, Klaus; Jackisch, Christian; Hauke, Jan; Dietrich, Dimo; Borde, Julika; Park-Simon, Tjoung-Won; Hanker, Lars; Prieske, Katharina; Schmidt, Sandra; Weber-Lassalle, Nana; Pohl-Rescigno, Esther; Kommoss, Stefan; Marmé, Frederik; Heitz, Florian; Stingl, Julia C; Schmutzler, Rita K; Harter, Philipp; Hahnen, Eric
肿瘤
肿瘤免疫
卵巢癌
发表日期：2022
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Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2: results of the observational AGO-TR1 study (NCT02222883)

杂合性缺失分析对 BRCA1/2 罕见种系变异分类的敏感性和特异性：AGO-TR1 观察性研究 (NCT02222883) 的结果

期刊:Journal of Medical Genetics
影响因子:3.7
doi:10.1136/jmedgenet-2020-107353
Hauke, Jan; Harter, Philipp; Ernst, Corinna; Burges, Alexander; Schmidt, Sandra; Reuss, Alexander; Borde, Julika; De Gregorio, Nikolaus; Dietrich, Dimo; El-Balat, Ahmed; Kayali, Mohamad; Gevensleben, Heidrun; Hilpert, Felix; Altmüller, Janine; Heimbach, André; Meier, Werner; Schoemig-Markiefka, Birgid; Thiele, Holger; Kimmig, Rainer; Nürnberg, Peter; Kast, Karin; Richters, Lisa; Sehouli, Jalid; Schmutzler, Rita K; Hahnen, Eric
BRCA1
AGO
发表日期：2022
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Nectin-4 is widely expressed in head and neck squamous cell carcinoma

Nectin-4在头颈部鳞状细胞癌中广泛表达

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.28299
Sanders, Christine; Lau, Jan-Frederic; Dietrich, Dimo; Strieth, Sebastian; Brossart, Peter; Kristiansen, Glen
细胞生物学
肿瘤
肿瘤免疫
发表日期：2022
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CTLA4 promoter hypomethylation is a negative prognostic biomarker at initial diagnosis but predicts response and favorable outcome to anti-PD-1 based immunotherapy in clear cell renal cell carcinoma

CTLA4启动子低甲基化在初始诊断时是一个不良预后生物标志物，但在透明细胞肾细胞癌中可预测对基于抗PD-1的免疫疗法的反应和良好预后。

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2021-002949
Klümper, Niklas; Ralser, Damian J; Zarbl, Romina; Schlack, Katrin; Schrader, Andres Jan; Rehlinghaus, Marc; Hoffmann, Michèle J; Niegisch, Günter; Uhlig, Annemarie; Trojan, Lutz; Steinestel, Julie; Steinestel, Konrad; Wirtz, Ralph M; Sikic, Danijel; Eckstein, Markus; Kristiansen, Glen; Toma, Marieta; Hölzel, Michael; Ritter, Manuel; Strieth, Sebastian; Ellinger, Jörg; Dietrich, Dimo
肿瘤
表观遗传
肿瘤免疫
肾癌
CTLA4
细胞生物学
PD-1
免疫/内分泌
发表日期：2021
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Ovarian Cancer-Specific BRCA-like Copy-Number Aberration Classifiers Detect Mutations Associated with Homologous Recombination Deficiency in the AGO-TR1 Trial

卵巢癌特异性BRCA样拷贝数异常分类器在AGO-TR1试验中检测与同源重组缺陷相关的突变

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-21-1673
Schouten, Philip C; Richters, Lisa; Vis, Daniel J; Kommoss, Stefan; van Dijk, Ewald; Ernst, Corinna; Kluin, Roelof J C; Marmé, Frederik; Lips, Esther H; Schmidt, Sandra; Scheerman, Esther; Prieske, Katharina; van Deurzen, Carolien H M; Burges, Alexander; Ewing-Graham, Patricia C; Dietrich, Dimo; Jager, Agnes; de Gregorio, Nikolaus; Hauke, Jan; du Bois, Andreas; Nederlof, Petra M; Wessels, Lodewyk F; Hahnen, Eric; Harter, Philipp; Linn, Sabine C; Schmutzler, Rita K
肿瘤
肿瘤免疫
AGO
卵巢癌
发表日期：2021
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CTLA4 promoter methylation predicts response and progression-free survival in stage IV melanoma treated with anti-CTLA-4 immunotherapy (ipilimumab)

CTLA4启动子甲基化可预测接受抗CTLA-4免疫疗法（伊匹木单抗）治疗的IV期黑色素瘤患者的疗效和无进展生存期

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-020-02777-4
Fietz, Simon; Zarbl, Romina; Niebel, Dennis; Posch, Christian; Brossart, Peter; Gielen, Gerrit H; Strieth, Sebastian; Pietsch, Torsten; Kristiansen, Glen; Bootz, Friedrich; Landsberg, Jennifer; Dietrich, Dimo
CTLA4
黑色素瘤
表观遗传
免疫/内分泌
发表日期：2021
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Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

头颈部鳞状细胞癌中成纤维细胞生长因子（FGF）、FGF受体（FGFR）和细胞周期蛋白D1（CCND1）的DNA甲基化与转录活性、基因扩增、人乳头瘤病毒（HPV）状态以及对酪氨酸激酶抑制剂的敏感性相关。

期刊:Clinical Epigenetics
影响因子:4.4
doi:10.1186/s13148-021-01212-4
Bao, Yilin; Gabrielpillai, Jennis; Dietrich, Jörn; Zarbl, Romina; Strieth, Sebastian; Schröck, Friederike; Dietrich, Dimo
成纤维细胞
肿瘤
表观遗传
肿瘤免疫
DNA甲基化
信号转导
微生物学
细胞生物学
发表日期：2021
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