日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral-Like Immunomodulatory Responses and Potent Adjuvant Activity

拓展核酸纳米粒子的化学空间,以实现可调控的抗病毒样免疫调节反应和强效佐剂活性

Panigaj, Martin; Newton, Hannah S; Wang, Jian; Pandey, Laxmi; Avilla, Yelixza I; Nguyen, Phong; Chandler, Morgan; Halman, Justin; Radwan, Yasmine; Smith, Stephanie; Edmondson, Elijah; Difilippantonio, Simone; Sanders, Chelsea; Tran, Bao; Zhao, Yongmei; Xie, Shaojun; Cedrone, Edward; Neun, Barry W; Wanunu, Meni; Dokholyan, Nikolay V; Dobrovolskaia, Marina A; Afonin, Kirill A

Trastuzumab deruxtecan efficacy, FcRn-facilitated penetration of the blood-tumor barrier, and distribution to tumor cells in HER2+ brain metastasis model systems

曲妥珠单抗德鲁替康的疗效、FcRn介导的血肿瘤屏障穿透以及在HER2阳性脑转移模型系统中向肿瘤细胞的分布

Khan, Imran; Kumar, Dinesh; Zhang, Wei; Difilippantonio, Simone; Robinson, Christina; Wei, Debbie; Lipkowitz, Stanley; Lake, Ross; Fleming, Ronald; Steeg, Patricia S

The Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC

细胞周期蛋白C-CDK8/19介导激酶模块控制PRCC-TFE3驱动的肾上皮细胞衰老和TFE3-RCC的肿瘤发生。

Kuroda, Shoichiro; Funasaki, Shintaro; Nishizawa, Hidekazu; Schmidt, Laura S; Kurahashi, Ryoma; Ito, Takaaki; Arima, Yuichiro; Tanaka, Miwa; Kitada, Atsuya; James, Amy M; Hasumi, Hisashi; Jikuya, Ryosuke; Makiyama, Kazuhide; Kurotaki, Daisuke; Minami, Takashi; Difilippantonio, Simone; Linehan, W Marston; Oike, Yuichi; Sawa, Tomohiro; Tanaka, Yasuhito; Suda, Toshio; Yokokawa, Ryuji; Nakamura, Takuro; Baba, Masaya; Kamba, Tomomi

Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy

靶向颗粒酶B的淬灭活性探针用于评估肿瘤对免疫疗法的反应

Kazim, Muhammad; Ganguly, Arghya; Malespini, Sebastian M; Thang, Lai; Patel, Nimit L; Kim, Caleb; Thakur, Kalyani; Kalen, Joseph D; Calcagno, Claudia; Difilippantonio, Simone; Yoo, Euna

Transfer RNA acetylation regulates in vivo mammalian stress signaling

转移RNA乙酰化调控哺乳动物体内应激信号传导

Thalalla Gamage, Supuni; Khoogar, Roxane; Howpay Manage, Shereen; DaRos, Judey T; Crawford, McKenna C; Georgeson, Joe; Polevoda, Bogdan V; Sanders, Chelsea; Lee, Kendall A; Nance, Kellie D; Iyer, Vinithra; Kustanovich, Anatoly; Perez, Minervo; Thu, Chu T; Nance, Sam R; Amin, Ruhul; Miller, Christine N; Holewinski, Ronald J; Das, Sudipto; Meyer, Thomas J; Koparde, Vishal; Yang, Acong; Jailwala, Parthav; Nguyen, Joe T; Andresson, Thorkell; Hunter, Kent; Gu, Shuo; Mock, Beverly A; Edmondson, Elijah F; Difilippantonio, Simone; Chari, Raj; Schwartz, Schraga; O'Connell, Mitchell R; Wu, Colin Chih-Chien; Meier, Jordan L

Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.

通过抑制或降解激酶 LZK 来靶向 c-MYC 和获得功能的 p53,可以抑制 HNSCC 肿瘤的生长

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, Karpińska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John

Activity of direct KRAS(G12C) inhibitors in preclinical models of pediatric cancer.

直接 KRAS(G12C) 抑制剂在儿童癌症临床前模型中的活性。

Price Hannah E, Stauffer Stacey, Lee Hyun, Isanogle Kristine A, Wu Ying, Powell Katie, Baker Andrew, Stauffer Lucas, Perciaccante Andrew J, Jewell Connor P, Hernandez Edjay R, Aljabri Ashwaq K, Odeniyide Patience, Pratilas Christine A, Burgan William, Edmondson Elijah F, Difilippantonio Simone, Kortum Robert L, Shern Jack F, Jenkins Lisa M, Rossman Kent L, Yohe Marielle E

Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.

利用新型 NAMPT 抑制剂 OT-82 靶向 FH 缺陷型遗传性平滑肌瘤病和肾细胞癌中的 NAD+ 代谢脆弱性

Najera Susana S, Ricketts Christopher J, Schmidt Laura S, Medina Julia I, Saito Keita, Ileva Lilia, Brender Jeffrey R, James Amy M, Peer Cody J, Gouker Brad, Karim Baktiar O, Chernova Olga, Wells Catherine, Wei Ming-Hui, Yang Youfeng, Zhang Xiaohu, Klumpp-Thomas Carleen, Travers Jameson, Chen Lu, Wilson Kelli M, Issaq Sameer H, Figg William D, Difilippantonio Simone, Kalen Joseph D, Krishna Murali C, Thomas Craig J, Ceribelli Michele, Heske Christine M, Crooks Daniel R, Meier Jordan L

IRAK1/4/pan-FLT3 Kinase Inhibitors with Reduced hERG Block as Treatments for Acute Myeloid Leukemia

降低hERG阻滞的IRAK1/4/泛FLT3激酶抑制剂可治疗急性髓系白血病

Hoyt, Scott B; Finocchio, Chris J; Croll, Elizabeth; Tawa, Gregory J; Zhang, Mingliang; Wang, Jiangong; Li, Huixi; Ma, Li; Li, Kaikai; Zhang, Xiaohu; Xu, Xin; Shah, Pranav; Fang, Yuhong; Bolanos, Lyndsey C; Gracia-Maldonado, Gabriel; Kolt, Amal; Robinson, Christina; Free, Jessica; Edmondson, Elijah F; Difilippantonio, Simone; Jones, LaQuita M; Culver-Cochran, Ashley E; Rosenbaum, Jan S; Starczynowski, Daniel T; Thomas, Craig J

Immune profile diversity is achieved with synthetic TLR4 agonists combined with the RG1-VLP vaccine in mice.

在小鼠中,将合成的 TLR4 激动剂与 RG1-VLP 疫苗结合使用,可以实现免疫谱多样性

Matthews Rebecca L, Khan Nazneen, Beckman Bradley, Sharma Simran, Dietz Zackary, Picking William D, Izmirlian Grant, Sanders Chelsea, Stocks Stacy M, Difilippantonio Simone, Kirnbauer Reinhard, Roden Richard B, Pinto Ligia A, Shoemaker Robert H, Ernst Robert K, Marshall Jason D