日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Charge matters: how flanking substrate charge modulates O-glycan Core elongation

电荷很重要:侧翼底物电荷如何调节O-聚糖核心的延伸

Ballard, Collin J; Smutny, Matthew R; Chau, Lam D; Wong, Collin K; Aharoni, Haley M; Lee, Hana K; Chapla, Digantkumar G; Hurtado-Guerrero, Ramon; Moremen, Kelley W; Gerken, Thomas A

Integrated chemoenzymatic synthesis of a comprehensive sulfated ganglioside glycan library to decipher functional sulfoglycomics and sialoglycomics

利用化学酶法合成全面的硫酸化神经节苷脂聚糖库,以解析功能性硫酸化糖组学和唾液酸糖组学。

Xu, Zhuojia; Liu, Yating; Liu, Jialin; Ma, Wenjing; Zhang, Zhumin; Chapla, Digantkumar G; Wen, Liuqing; Moremen, Kelley W; Yi, Wen; Li, Tiehai

Chemoenzymatic Synthesis of Sulfated N-Glycans Recognized by Siglecs and Other Glycan-Binding Proteins

Siglecs 和其他聚糖结合蛋白识别的硫酸化 N-聚糖的化学酶合成

Kun Huang, Eleanor E Bashian, Guanghui Zong, Corwin M Nycholat, Ryan McBride, Margaryta Gomozkova, Shengyang Wang, Chin Huang, Digantkumar G Chapla, Edward N Schmidt, Matthew Macauley, Kelley W Moremen, James C Paulson, Lai-Xi Wang

Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase

利用化学酶法简化液相中复杂糖肽的组装

Ma, Wenjing; Deng, Yaqi; Xu, Zhuojia; Liu, Xingbang; Chapla, Digantkumar G; Moremen, Kelley W; Wen, Liuqing; Li, Tiehai

A universal glycoenzyme biosynthesis pipeline that enables efficient cell-free remodeling of glycans

通用的糖酶生物合成流程,可实现高效的无细胞聚糖重塑

Thapakorn Jaroentomeechai, Yong Hyun Kwon, Yiwen Liu, Olivia Young, Ruchika Bhawal, Joshua D Wilson, Mingji Li, Digantkumar G Chapla, Kelley W Moremen, Michael C Jewett, Dario Mizrachi, Matthew P DeLisa

Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness

细胞外唾液酸转移酶st6gal1在乳腺肿瘤细胞生长和侵袭性中的作用

Nitai C Hait, Aparna Maiti, Rongrong Wu, Valerie L Andersen, Chang-Chieh Hsu, Yun Wu, Digantkumar G Chapla, Kazuaki Takabe, Michael E Rusiniak, Wiam Bshara, Jianmin Zhang, Kelley W Moremen, Joseph T Y Lau

Site-selective sulfation of N-glycans by human GlcNAc-6-O-sulfotransferase 1 (CHST2) and chemoenzymatic synthesis of sulfated antibody glycoforms

人类 GlcNAc-6-O-磺基转移酶 1 (CHST2) 对 N-糖链进行位点选择性硫酸化以及硫酸化抗体糖基形式的化学酶促合成

Kun Huang, Chao Li, Guanghui Zong, Sunaina Kiran Prabhu, Digantkumar G Chapla, Kelley W Moremen, Lai-Xi Wang

Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy

利用CD22和选择素的糖配体对NK细胞进行糖基化改造,用于B细胞淋巴瘤治疗

Hong, Senlian; Yu, Chenhua; Wang, Peng; Shi, Yujie; Cao, Weiqian; Cheng, Bo; Chapla, Digantkumar G; Ma, Yuanhui; Li, Jie; Rodrigues, Emily; Narimatsu, Yoshiki; Yates, John R 3rd; Chen, Xing; Clausen, Henrik; Moremen, Kelly W; Macauley, Matthew Scott; Paulson, James C; Wu, Peng

Modulation of Siglec-7 Signaling Via In Situ-Created High-Affinity cis-Ligands

通过原位生成的高亲和力顺式配体调节 Siglec-7 信号传导

Hong, Senlian; Yu, Chenhua; Rodrigues, Emily; Shi, Yujie; Chen, Hongmin; Wang, Peng; Chapla, Digantkumar G; Gao, Tao; Zhuang, Ruoxuan; Moremen, Kelley W; Paulson, James C; Macauley, Matthew S; Wu, Peng

CUPRA-ZYME: An Assay for Measuring Carbohydrate-Active Enzyme Activities, Pathways, and Substrate Specificities

CUPRA-ZYME:一种用于测量碳水化合物活性酶活性、途径和底物特异性的检测方法

Li, Zhixiong; Kitov, Pavel I; Kitova, Elena N; Mozenah, Fahima; Rodrigues, Emily; Chapla, Digantkumar G; Moremen, Kelley W; Macauley, Matthew S; Klassen, John S