Digby Gregory J相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism

对M₁变构激动剂的进一步研究：细微的结构变化可消除M₁变构激动作用，并导致泛mAChR正构拮抗作用

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2012.10.132

Sheffler, Douglas J; Sevel, Christian; Le, Uyen; Lovell, Kimberly M; Tarr, James C; Carrington, Sheridan J S; Cho, Hyekyung P; Digby, Gregory J; Niswender, Colleen M; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Lindsley, Craig W

发表日期：2013

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Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode

M(1)激动剂VU0364572的化学修饰揭示了药理学中的分子开关和双位点结合模式

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/cn300103e

Digby, Gregory J; Utley, Thomas J; Lamsal, Atin; Sevel, Christian; Sheffler, Douglas J; Lebois, Evan P; Bridges, Thomas M; Wood, Michael R; Niswender, Colleen M; Lindsley, Craig W; Conn, P Jeffrey

发表日期：2012

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Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071

开发一种源自 MLPCN 探针 ML071 的高选择性、口服生物利用度高且能穿透中枢神经系统的 M1 激动剂

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2011.08.084

Lebois, Evan P; Digby, Gregory J; Sheffler, Douglas J; Melancon, Bruce J; Tarr, James C; Cho, Hyekyung P; Miller, Nicole R; Morrison, Ryan; Bridges, Thomas M; Xiang, Zixiu; Daniels, J Scott; Wood, Michael R; Conn, P Jeffrey; Lindsley, Craig W

发表日期：2011

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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders

毒蕈碱受体变构激活剂作为治疗中枢神经系统疾病的新方法

期刊:Molecular Biosystems

doi:10.1039/c002938f

Digby, Gregory J; Shirey, Jana K; Conn, P Jeffrey

发表日期：2010

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Differential dissociation of G protein heterotrimers.

G蛋白异源三聚体的差异性解离

期刊:Journal of Physiology-London

影响因子:4.4

doi:10.1113/jphysiol.2008.153965

Digby Gregory J, Sethi Pooja R, Lambert Nevin A

免疫/内分泌

发表日期：2008

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