文献库，生知库 | 链接生命科学的每一步

日期影响因子

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1

酯类前药 NLRP3 炎症小体抑制剂 NT-0796 因羧酸酯酶-1 的局部表达而被激活，从而具有脑活性。

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.5c00843

Digby, Zsofia; Diamond, Christine; Wescott, Heather; Smolak, Pam; Thornton, Peter; Lindsay, Nicola; Gabel, Christopher A; Clarke, Nicholas; Watt, Alan P

免疫/内分泌

发表日期：2026

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Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson's Disease

NLRP3抑制剂NT-0796在帕金森病患者中的抗神经炎症和抗炎作用

期刊:Movement Disorders

影响因子:7.6

doi:10.1002/mds.30307

Clarke, Nicholas; Thornton, Peter; Reader, Valérie; Lindsay, Nicola; Digby, Zsofia; Mullen, Bianca; Gorman, Michelle; Jacobson, Eric; Langdon, Grant; Johnstone, Hilary; Wheeler, Alistair; Watt, Alan P

发表日期：2025

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Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders.

NT-0527 是一种可穿透血脑屏障的 NLRP3 炎症小体抑制剂，适用于作为神经炎症性疾病的体内治疗药物

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d5md00639b

Harrison David, Billinton Andy, Bock Mark G, Clarke Nicholas P, Digby Zsofia, Gabel Christopher A, Lindsay Nicola, Reader ValÃ©rie, Scanlon Jane, Smolak Pamela, Thornton Peter, Wescott Heather, Watt Alan P

发表日期：2025

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The NLRP3 inhibitor NT-0796 enhances and sustains GLP-1R agonist-mediated weight loss in a murine diet-induced obesity model

NLRP3抑制剂NT-0796可增强并维持GLP-1R激动剂介导的小鼠饮食诱导肥胖模型中的体重减轻。

doi:10.1002/oby.24305

Thornton, Peter; Reader, Valérie; Digby, Zsofia; Doedens, John; Lindsay, Nicola; Clarke, Nicholas; Watt, Alan P

发表日期：2025

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A high-resolution mRNA expression time course of embryonic development in zebrafish

斑马鱼胚胎发育过程中高分辨率mRNA表达时间进程

影响因子:6.4

doi:10.7554/eLife.30860

White, Richard J; Collins, John E; Sealy, Ian M; Wali, Neha; Dooley, Christopher M; Digby, Zsofia; Stemple, Derek L; Murphy, Daniel N; Billis, Konstantinos; Hourlier, Thibaut; Füllgrabe, Anja; Davis, Matthew P; Enright, Anton J; Busch-Nentwich, Elisabeth M

发育与干细胞

发表日期：2017

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Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish

染色质修饰因子Kdm2aa的缺失会导致斑马鱼发生不依赖于BrafV600E的自发性黑色素瘤。

期刊:PLoS Genetics

影响因子:3.7

doi:10.1371/journal.pgen.1006959

Scahill, Catherine M; Digby, Zsofia; Sealy, Ian M; Wojciechowska, Sonia; White, Richard J; Collins, John E; Stemple, Derek L; Bartke, Till; Mathers, Marie E; Patton, E Elizabeth; Busch-Nentwich, Elisabeth M

发表日期：2017

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The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish

在斑马鱼中，杂合端粒酶突变亲本的年龄会影响其后代的成年表型，而与基因型无关。

期刊:Wellcome Open Research

doi:10.12688/wellcomeopenres.12530.2

Scahill, Catherine M; Digby, Zsofia; Sealy, Ian M; White, Richard J; Wali, Neha; Collins, John E; Stemple, Derek L; Busch-Nentwich, Elisabeth M

发表日期：2017

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