日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

在临床前研究中,RH5.1-CyRPA-Ripr抗原组合疫苗与RH5.1相比,疗效提升甚微。

Healer, Julie; Thompson, Jennifer K; Mackwell, Karen L; Browne, Cecille D; Seager, Benjamin A; Ngo, Anna; Lowes, Kym N; Silk, Sarah E; Pulido, David; King, Lloyd D W; Christen, Jayne M; Noe, Amy R; Kotraiah, Vinayaka; Masendycz, Paul J; Rajagopalan, Rajkannan; Lucas, Leanne; Stanford, Marianne M; Soisson, Lorraine; Diggs, Carter; Miller, Robin; Youll, Susan; Wycherley, Kaye; Draper, Simon J; Cowman, Alan F

A three-antigen Plasmodium falciparum DNA prime-Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults

一种包含三种抗原的恶性疟原虫DNA启动-腺病毒加强免疫的疟疾疫苗方案优于两种抗原的方案,并且能够保护健康、未感染过疟疾的成年人免受可控的人类疟疾感染。

Sklar, Marvin J; Maiolatesi, Santina; Patterson, Noelle; Sedegah, Martha; Limbach, Keith; Teneza-Mora, Nimfa; Chuang, Ilin; Hollis-Perry, K Monique; Banania, Jo Glenna; Guzman, Ivelese; Ganeshan, Harini; Reyes, Sharina; Hollingdale, Michael R; Wong, Mimi; Lindstrom, Ashley; Reyes, Anatalio; Alcorta, Yolanda; Garver, Lindsey; Bankard, Kelli; Belmonte, Arnel; Belmonte, Maria; Huang, Jun; Gowda, Kalpana; Inoue, Sandra; Velasco, Rachel; Bergmann-Leitner, Elke; Hutter, Jack; Lee, Tida; Adams, Nehkonti; Chaudhury, Sidhartha; Hunt, Devin; Tamminga, Cindy; Berrie, Eleanor; Bellamy, Duncan; Bittaye, Mustapha; Ewer, Katie; Diggs, Carter; Soisson, Lorraine A; Lawrie, Alison; Hill, Adrian; Richie, Thomas L; Villasante, Eileen; Epstein, Judith E; Duplessis, Christopher A

Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02(A)

接种恶性疟原虫顶端膜抗原 1 候选疫苗 FMP2.1/AS02(A) 的马里儿童的免疫球蛋白 G 亚类和抗体亲和力反应

Berry, Andrea A; Gottlieb, Eric R; Kouriba, Bourema; Diarra, Issa; Thera, Mahamadou A; Dutta, Sheetij; Coulibaly, Drissa; Ouattara, Amed; Niangaly, Amadou; Kone, Abdoulaye K; Traore, Karim; Tolo, Youssouf; Mishcherkin, Vladimir; Soisson, Lorraine; Diggs, Carter L; Blackwelder, William C; Laurens, Matthew B; Sztein, Marcelo B; Doumbo, Ogobara K; Plowe, Christopher V; Lyke, Kirsten E

Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

利用血期恶性疟原虫控制性人类疟疾感染模型评估恶性疟原虫顶端膜抗原1疫苗FMP2.1/AS01的疗效

Payne, Ruth O; Milne, Kathryn H; Elias, Sean C; Edwards, Nick J; Douglas, Alexander D; Brown, Rebecca E; Silk, Sarah E; Biswas, Sumi; Miura, Kazutoyo; Roberts, Rachel; Rampling, Thomas W; Venkatraman, Navin; Hodgson, Susanne H; Labbé, Geneviève M; Halstead, Fenella D; Poulton, Ian D; Nugent, Fay L; de Graaf, Hans; Sukhtankar, Priya; Williams, Nicola C; Ockenhouse, Christian F; Kathcart, April K; Qabar, Aziz N; Waters, Norman C; Soisson, Lorraine A; Birkett, Ashley J; Cooke, Graham S; Faust, Saul N; Woods, Colleen; Ivinson, Karen; McCarthy, James S; Diggs, Carter L; Vekemans, Johan; Long, Carole A; Hill, Adrian V S; Lawrie, Alison M; Dutta, Sheetij; Draper, Simon J

Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes

DNA启动/腺病毒加强免疫后对疟疾的无菌免疫与靶向AMA1 I类表位的效应记忆CD8+T细胞有关。

Sedegah, Martha; Hollingdale, Michael R; Farooq, Fouzia; Ganeshan, Harini; Belmonte, Maria; Kim, Yohan; Peters, Bjoern; Sette, Alessandro; Huang, Jun; McGrath, Shannon; Abot, Esteban; Limbach, Keith; Shi, Meng; Soisson, Lorraine; Diggs, Carter; Chuang, Ilin; Tamminga, Cindy; Epstein, Judith E; Villasante, Eileen; Richie, Thomas L

Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications

疟疾血液期疫苗等位基因特异性效力的分子基础:对疫苗研发的启示

Ouattara, Amed; Takala-Harrison, Shannon; Thera, Mahamadou A; Coulibaly, Drissa; Niangaly, Amadou; Saye, Renion; Tolo, Youssouf; Dutta, Sheetij; Heppner, D Gray; Soisson, Lorraine; Diggs, Carter L; Vekemans, Johan; Cohen, Joe; Blackwelder, William C; Dube, Tina; Laurens, Matthew B; Doumbo, Ogobara K; Plowe, Christopher V

Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection

编码 CSP 和 AMA1 的 5 型人腺病毒载体疟原虫 NMRC-M3V-Ad-PfCA 疫苗安全、耐受性良好且具有免疫原性,但不能预防受控的人类疟疾感染。

Tamminga, Cindy; Sedegah, Martha; Maiolatesi, Santina; Fedders, Charlotte; Reyes, Sharina; Reyes, Anatalio; Vasquez, Carlos; Alcorta, Yolanda; Chuang, Ilin; Spring, Michele; Kavanaugh, Michael; Ganeshan, Harini; Huang, Jun; Belmonte, Maria; Abot, Esteban; Belmonte, Arnel; Banania, Joglenna; Farooq, Fouzia; Murphy, Jittawadee; Komisar, Jack; Richie, Nancy O; Bennett, Jason; Limbach, Keith; Patterson, Noelle B; Bruder, Joseph T; Shi, Meng; Miller, Edward; Dutta, Sheetij; Diggs, Carter; Soisson, Lorraine A; Hollingdale, Michael R; Epstein, Judith E; Richie, Thomas L

Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01

两项 1 期串联研究的结果评估了疫苗候选抗原恶性疟原虫 FVO 裂殖子表面蛋白-1 (MSP1(42)) 与佐剂系统 AS01 联合肌内注射的安全性、反应原性和免疫原性。

Otsyula, Nekoye; Angov, Evelina; Bergmann-Leitner, Elke; Koech, Margaret; Khan, Farhat; Bennett, Jason; Otieno, Lucas; Cummings, James; Andagalu, Ben; Tosh, Donna; Waitumbi, John; Richie, Nancy; Shi, Meng; Miller, Lori; Otieno, Walter; Otieno, Godfrey Allan; Ware, Lisa; House, Brent; Godeaux, Olivier; Dubois, Marie-Claude; Ogutu, Bernhards; Ballou, W Ripley; Soisson, Lorraine; Diggs, Carter; Cohen, Joe; Polhemus, Mark; Heppner, D Gray Jr; Ockenhouse, Christian F; Spring, Michele D

A field trial to assess a blood-stage malaria vaccine

一项评估疟疾血液期疫苗的现场试验

Thera, Mahamadou A; Doumbo, Ogobara K; Coulibaly, Drissa; Laurens, Matthew B; Ouattara, Amed; Kone, Abdoulaye K; Guindo, Ando B; Traore, Karim; Traore, Idrissa; Kouriba, Bourema; Diallo, Dapa A; Diarra, Issa; Daou, Modibo; Dolo, Amagana; Tolo, Youssouf; Sissoko, Mahamadou S; Niangaly, Amadou; Sissoko, Mady; Takala-Harrison, Shannon; Lyke, Kirsten E; Wu, Yukun; Blackwelder, William C; Godeaux, Olivier; Vekemans, Johan; Dubois, Marie-Claude; Ballou, W Ripley; Cohen, Joe; Thompson, Darby; Dube, Tina; Soisson, Lorraine; Diggs, Carter L; House, Brent; Lanar, David E; Dutta, Sheetij; Heppner, D Gray Jr; Plowe, Christopher V

Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial

AMA1疟疾疫苗在马里儿童中的安全性和免疫原性:一项1期随机对照试验的结果

Thera, Mahamadou A; Doumbo, Ogobara K; Coulibaly, Drissa; Laurens, Matthew B; Kone, Abdoulaye K; Guindo, Ando B; Traore, Karim; Sissoko, Mady; Diallo, Dapa A; Diarra, Issa; Kouriba, Bourema; Daou, Modibo; Dolo, Amagana; Baby, Mounirou; Sissoko, Mahamadou S; Sagara, Issaka; Niangaly, Amadou; Traore, Idrissa; Olotu, Ally; Godeaux, Olivier; Leach, Amanda; Dubois, Marie-Claude; Ballou, W Ripley; Cohen, Joe; Thompson, Darby; Dube, Tina; Soisson, Lorraine; Diggs, Carter L; Takala, Shannon L; Lyke, Kirsten E; House, Brent; Lanar, David E; Dutta, Sheetij; Heppner, D Gray; Plowe, Christopher V