日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice.

多巴胺能REST与他莫昔芬诱导的雌性小鼠抗锰中毒的神经保护作用有关。

Pajarillo Edward, Digman Alexis, Ajayi Itunu, Kim Sanghoon, Son Deok-Soo, Aschner Michael, Lee Eunsook

Tamoxifen induces protection against manganese toxicity by REST upregulation via the ER-α/Wnt/β-catenin pathway in neuronal cells

他莫昔芬通过ER-α/Wnt/β-catenin通路上调REST表达,从而在神经元细胞中发挥抗锰毒性的保护作用。

Digman, Alexis; Pajarillo, Edward; Kim, Sanghoon; Ajayi, Itunu; Son, Deok-Soo; Aschner, Michael; Lee, Eunsook

Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice

多巴胺能RE1沉默转录因子(REST)在锰诱导的小鼠行为缺陷和多巴胺能及血清素能神经传递失调中的作用

Kim, Sanghoon; Pajarillo, Edward; Digman, Alexis; Ajayi, Itunu; Son, Deok-Soo; Aschner, Michael; Lee, Eunsook

CAD (Cath. a-Differentiated) Cells Produce Dopamine along with Dopamine-Synthesizing Enzymes

CAD(Cath. a-Differentiated)细胞产生多巴胺以及多巴胺合成酶。

Kim, Sanghoon; Pajarillo, Edward; Digman, Alexis; Ajayi, Itunu; Son, Deok-Soo; Aschner, Michael; Lee, Eunsook

Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism.

他莫昔芬通过基因组 ER-α 机制减弱锰诱导的神经元 REST 失调。

Digman Alexis, Pajarillo Edward, Kim Sanghoon, Ajayi Itunu, Son Deok-Soo, Aschner Michael, Lee Eunsook

Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17β-estradiol afforded protection against this manganese toxicity.

小胶质细胞 Sp1 诱导 LRRK2 上调以应对锰暴露,而 17β-雌二醇可保护其免受锰毒性的影响

Nyarko-Danquah Ivan, Pajarillo Edward, Kim Sanghoon, Digman Alexis, Multani Harpreet Kaur, Ajayi Itunu, Son Deok-Soo, Aschner Michael, Lee Eunsook

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

锰诱导神经毒性的机制及神经治疗策略的研究进展

Pajarillo, Edward; Nyarko-Danquah, Ivan; Digman, Alexis; Multani, Harpreet Kaur; Kim, Sanghoon; Gaspard, Patric; Aschner, Michael; Lee, Eunsook

Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms

锰通过多种转运蛋白在大脑中积累及其神经毒性机制

Nyarko-Danquah, Ivan; Pajarillo, Edward; Digman, Alexis; Soliman, Karam F A; Aschner, Michael; Lee, Eunsook