日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry

FOXP3的表达依赖于细胞类型特异性的顺式调控元件和转录因子回路。

Jennifer M Umhoefer ,Maya M Arce ,Sivakanthan Kasinathan ,Sean Whalen ,Rama Dajani ,Sanjana Subramanya ,Laine Goudy ,Julia A Belk ,Royce Zhou ,Minh T N Pham ,Wenxi Zhang ,Rosmely Hernandez ,Carinna Tran ,Nikhita Kirthivasan ,Jacob W Freimer ,Cody T Mowery ,Vinh Nguyen ,Mineto Ota ,Benjamin G Gowen ,Dimitre R Simeonov ,Gemma L Curie ,Zhongmei Li ,Andy Y Chen ,Jacob E Corn ,Howard Y Chang ,Qizhi Tang ,Luke A Gilbert ,Ansuman T Satpathy ,Katherine S Pollard ,Alexander Marson

Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells

对顺式基因调控的系统性解码揭示了人类T细胞中多基因共刺激受体基因座的上下文依赖性调控

Cody T Mowery,Jacob W Freimer,Zeyu Chen,Salvador Casaní-Galdón,Jennifer M Umhoefer,Maya M Arce,Ketrin Gjoni,Bence Daniel,Katalin Sandor,Benjamin G Gowen,Vinh Nguyen,Dimitre R Simeonov,Christian M Garrido,Gemma L Curie,Ralf Schmidt,Zachary Steinhart,Ansuman T Satpathy,Katherine S Pollard,Jacob E Corn,Bradley E Bernstein,Chun Jimmie Ye,Alexander Marson

Deciphering regulation of FOXP3 expression in human conventional T cells

揭示人类常规 T 细胞中 FOXP3 表达的调控

Jennifer M Umhoefer, Maya M Arce, Rama Dajani, Julia A Belk, Cody T Mowery, Vinh Nguyen, Benjamin G Gowen, Dimitre R Simeonov, Gemma L Curie, Jacob E Corn, Howard Y Chang, Alexander Marson

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

非编码序列变异揭示了白细胞介素 2 反馈回路的脆弱性,并影响自身免疫性疾病的风险。

Simeonov, Dimitre R; Park, Kyemyung; Cortez, Jessica T; Young, Arabella; Li, Zhongmei; Nguyen, Vinh; Umhoefer, Jennifer; Indart, Alyssa C; Woo, Jonathan M; Anderson, Mark S; Tsang, John S; Germain, Ronald N; Wong, Harikesh S; Marson, Alexander

The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation

lncRNA Malat1 抑制 miR-15/16 以增强细胞毒性 T 细胞活化和记忆细胞形成

Benjamin D Wheeler, John D Gagnon, Wandi S Zhu, Priscila Muñoz-Sandoval, Simon K Wong, Dimitre R Simeonov, Zhongmei Li, Rachel Debarge, Matthew H Spitzer, Alexander Marson, K Mark Ansel

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

RUNX1介导的转录导致RASGRP1表达失调,从而促进自身免疫。

Matthijs J D Baars ,Thera Douma ,Dimitre R Simeonov ,Darienne R Myers ,Kayla Kulhanek ,Saikat Banerjee ,Susan Zwakenberg ,Marijke P Baltissen ,Mojtaba Amini ,Sytze de Roock ,Femke van Wijk ,Michiel Vermeulen ,Alexander Marson ,Jeroen P Roose ,Yvonne Vercoulen

CRISPR screen in regulatory T cells reveals modulators of Foxp3

在调节性T细胞中进行CRISPR筛选,揭示了Foxp3的调节因子

Jessica T Cortez # ,Elena Montauti # ,Eric Shifrut ,Jovylyn Gatchalian ,Yusi Zhang ,Oren Shaked ,Yuanming Xu ,Theodore L Roth ,Dimitre R Simeonov ,Yana Zhang ,Siqi Chen ,Zhongmei Li ,Jonathan M Woo ,Josephine Ho ,Ian A Vogel ,Grace Y Prator ,Bin Zhang ,Youjin Lee ,Zhaolin Sun ,Igal Ifergan ,Frédéric Van Gool ,Diana C Hargreaves ,Jeffrey A Bluestone ,Alexander Marson ,Deyu Fang

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

功能性CRISPR剖析控制人类调节性T细胞身份的基因网络

Kathrin Schumann #, Siddharth S Raju #, Michael Lauber, Saskia Kolb, Eric Shifrut, Jessica T Cortez, Nikolaos Skartsis, Vinh Q Nguyen, Jonathan M Woo, Theodore L Roth, Ruby Yu, Michelle L T Nguyen, Dimitre R Simeonov, David N Nguyen, Sasha Targ, Rachel E Gate, Qizhi Tang, Jeffrey A Bluestone, Matthe

Thymic regulatory T cells arise via two distinct developmental programs

胸腺调节性 T 细胞通过两个不同的发育程序产生

David L Owen, Shawn A Mahmud, Louisa E Sjaastad, Jason B Williams, Justin A Spanier, Dimitre R Simeonov, Roland Ruscher, Weishan Huang, Irina Proekt, Corey N Miller, Can Hekim, Jonathan C Jeschke, Praful Aggarwal, Ulrich Broeckel, Rebecca S LaRue, Christine M Henzler, Maria-Luisa Alegre, Mark S Ande

A large CRISPR-induced bystander mutation causes immune dysregulation

CRISPR 诱导的大规模旁观者突变导致免疫失调

Dimitre R Simeonov, Alexander J Brandt, Alice Y Chan, Jessica T Cortez, Zhongmei Li, Jonathan M Woo, Youjin Lee, Claudia M B Carvalho, Alyssa C Indart, Theodore L Roth, James Zou, Andrew P May, James R Lupski, Mark S Anderson, F William Buaas, Daniel S Rokhsar, Alexander Marson8