Dimitrios L相关文献与解析，生知库 | 链接生命科学的每一步

Ehlen, Lukas; Farrera-Sal, Martí; Szyska, Martin; Arndt, Janine; Schallenberg, Simon; Scholz, Cedric; Yang, Mingxing; Vollbrecht, Claudia; Löwa, Anna; Friedrich, Rebecca; Mai, Marco; Peter, Lena; Picht, Samira; Schulenberg, Sarah; Geray, Daniel; Korus, Gabriela; Sommerfeld, Anke; Treue, Denise; Strauchmann, Julia; Elsner, Aron; Kath, Jonas; Vallone, Valeria Fernandez; Joosten, Maria; Klatte-Schulz, Franka; Petersen, Ansgar; Stachelscheid, Harald; Wagner, Dimitrios L; Spies, Claudia; Rückert, Jens-Carsten; Hocke, Andreas C; Polansky, Julia K; Stark, Regina; Klein, Oliver; Schmueck-Henneresse, Michael

肿瘤

T细胞

肿瘤免疫

Come together: The BE-TILs-Efficient multiplex base editing of tumor-infiltrating lymphocytes

汇聚一堂：BE-TILs——肿瘤浸润淋巴细胞的高效多重碱基编辑

期刊:Molecular Therapy Oncology

影响因子:5.3

doi:10.1016/j.omton.2026.201135

Glaser, Viktor; Wagner, Dimitrios L; Bexte, Tobias

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

利用CRISPR敲入细胞因子基因疗法个性化肿瘤微环境，增强CAR-T细胞疗法在实体瘤中的疗效

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-67328-w

Launspach, Michael; Macos, Julia; Afzal, Shoaib; Hohmann, Janik; Appis, Marc L; Pilgram, Maximilian; Beez, Stefanie; Ohlendorf, Emily; van der Ven, Casper F T; Lachiheb, Chahrazad; Töws, Karin; Andersch, Lena; Jens, Marvin; Zirngibl, Felix; Kath, Jonas; Stecklum, Maria; Rodriguez-Fos, Elias; Anders, Kathleen; Wagner, Dimitrios L; Henssen, Anton G; Kühn, Ralf; Eggert, Angelika; Künkele, Annette

HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

在人源化小鼠移植模型中，HLA配型或HLA I/II类基因的CRISPR编辑可使同种异体人源调节性T细胞疗法实现植入并发挥有效功能。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-64945-3.

Oliver McCallion #,Weijie Du #,Viktor Glaser #,Kate Milward,Sarah Short,Merve Bilici,Amy Cross,Helen Stark,Clemens Franke,Jonas Kath,Mikhail Valkov,Mingxing Yang,Leila Amini,Annette Künkele,Julia K Polansky,Michael Schmueck-Henneresse,Hans-Dieter Volk,Petra Reinke,Dimitrios L Wagner,Joanna Hester,Fadi Issa

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

通过基因编辑CD3ε来重定向调节性T细胞，用于过继性T细胞转移。

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.01.045

Du, Weijie; Noyan, Fatih; McCallion, Oliver; Drosdek, Vanessa; Kath, Jonas; Glaser, Viktor; Fuster-Garcia, Carla; Yang, Mingxing; Stein, Maik; Franke, Clemens; Pu, Yaolin; Weber, Olaf; Polansky, Julia K; Cathomen, Toni; Jaeckel, Elmar; Hester, Joanna; Issa, Fadi; Volk, Hans-Dieter; Schmueck-Henneresse, Michael; Reinke, Petra; Wagner, Dimitrios L

Next-generation multiplex-edited CAR-NK cells: more edits, more power?

新一代多重编辑 CAR-NK 细胞：更多编辑，更强效？

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2025-012841

Bexte, Tobias; Wagner, Dimitrios L

Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkin's lymphoma

既往化疗会降低B细胞非霍奇金淋巴瘤CAR-T细胞疗法中T细胞的质量

期刊:Journal for ImmunoTherapy of Cancer

影响因子:10.6

doi:10.1136/jitc-2024-010709

Herzberg, Charlotte; Schiele, Phillip; Walter, Anna Luzie; Hamm, Frederik; Obermayer, Benedikt; Kath, Jonas; Busch, David; Stroux, Andrea; Frick, Mareike; Penack, Olaf; Damm, Frederik; Wagner, Dimitrios L; Polansky, Julia; Bullinger, Lars; Künkele, Annette; Frentsch, Marco; Na, Il-Kang

Author Correction: Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells

作者更正：结合使用不同的 CRISPR 核酸酶进行同步基因敲入和碱基编辑可防止多重编辑的 CAR T 细胞发生易位。

期刊:Genome Biology

影响因子:9.4

doi:10.1186/s13059-025-03548-z

Glaser, Viktor; Flugel, Christian; Kath, Jonas; Du, Weijie; Drosdek, Vanessa; Franke, Clemens; Stein, Maik; Pruß, Axel; Schmueck-Henneresse, Michael; Volk, Hans-Dieter; Reinke, Petra; Wagner, Dimitrios L

Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cells

带有截短的Cas12a结合序列的单链HDR模板可提高原代人T细胞的基因敲入效率

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2025.102568

Nitulescu, Ana-Maria; Du, Weijie; Glaser, Viktor; Kath, Jonas; Aird, Eric J; Cullot, Grégoire; Greensmith, Robert; Mikkelsen, Nanna Steengaard; Stein, Maik; Bak, Rasmus O; Kaminski, Michael; Corn, Jacob E; Wagner, Dimitrios L

The role of PD-1/PD-L1 in overshooting osteoclastogenesis in periprosthetic joint infections

PD-1/PD-L1在假体周围关节感染中破骨细胞过度生成中的作用

期刊:Communications Biology

影响因子:5.2

doi:10.1038/s42003-025-08143-3

Yi Ren ，Denise Jahn ，Stefanie Donner ，Clemens Gwinner ，Weijie Du ，Dimitrios L Wagner ，Serafeim Tsitsilonis ，Carsten Perka ，Georg Duda ，Arne Kienzle

Lung tumouroids as a testing platform for precision CAR T cell therapy

肺肿瘤类器官作为精准CAR-T细胞疗法的测试平台

Come together: The BE-TILs-Efficient multiplex base editing of tumor-infiltrating lymphocytes

汇聚一堂：BE-TILs——肿瘤浸润淋巴细胞的高效多重碱基编辑

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

利用CRISPR敲入细胞因子基因疗法个性化肿瘤微环境，增强CAR-T细胞疗法在实体瘤中的疗效

HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

在人源化小鼠移植模型中，HLA配型或HLA I/II类基因的CRISPR编辑可使同种异体人源调节性T细胞疗法实现植入并发挥有效功能。

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer

通过基因编辑CD3ε来重定向调节性T细胞，用于过继性T细胞转移。

Next-generation multiplex-edited CAR-NK cells: more edits, more power?

新一代多重编辑 CAR-NK 细胞：更多编辑，更强效？

Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkin's lymphoma

既往化疗会降低B细胞非霍奇金淋巴瘤CAR-T细胞疗法中T细胞的质量

Author Correction: Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells

作者更正：结合使用不同的 CRISPR 核酸酶进行同步基因敲入和碱基编辑可防止多重编辑的 CAR T 细胞发生易位。

Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cells

带有截短的Cas12a结合序列的单链HDR模板可提高原代人T细胞的基因敲入效率

The role of PD-1/PD-L1 in overshooting osteoclastogenesis in periprosthetic joint infections

PD-1/PD-L1在假体周围关节感染中破骨细胞过度生成中的作用