日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis

BTK在人类干细胞模型和多发性硬化症小鼠模型中调节小胶质细胞功能和神经炎症

Ross C Gruber # ,Gregory S Wirak # ,Anna S Blazier ,Lan Lee ,Michael R Dufault ,Nellwyn Hagan ,Nathalie Chretien ,Michael LaMorte ,Timothy R Hammond ,Agnes Cheong ,Sean K Ryan ,Andrew Macklin ,Mindy Zhang ,Nilesh Pande ,Evis Havari ,Timothy J Turner ,Anthony Chomyk ,Emilie Christie ,Bruce D Trapp ,Dimitry Ofengeim

Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro

葡萄糖基神经酰胺合成酶的调节可改善小鼠肾脏病理,并在体外促进巨噬细胞效应功能。

Agnes Cheong ,Florin Craciun ,Hervé Husson ,Joseph Gans ,Javier Escobedo ,Yi-Chien Chang ,Lilu Guo ,Mariana Goncalves ,Nathan Kaplan ,Laurie A Smith ,Sarah Moreno ,Joseph Boulanger ,Shiguang Liu ,Jacqueline Saleh ,Mindy Zhang ,Anna S Blazier ,Weiliang Qiu ,Andrew Macklin ,Tejaswi Iyyanki ,Clément Chatelain ,Shameer Khader ,Thomas A Natoli ,Oxana Ibraghimov-Beskrovnaya ,Dimitry Ofengeim ,Jonathan D Proto

Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

小胶质细胞铁死亡受 SEC24B 调控,并导致神经退行性变。

Sean K Ryan,Matija Zelic,Yingnan Han,Erin Teeple,Luoman Chen,Mahdiar Sadeghi,Srinivas Shankara,Lilu Guo,Cong Li,Fabrizio Pontarelli,Elizabeth H Jensen,Ashley L Comer,Dinesh Kumar,Mindy Zhang,Joseph Gans,Bailin Zhang,Jonathan D Proto,Jacqueline Saleh,James C Dodge,Virginia Savova,Deepak Rajpal,Dimitry Ofengeim,Timothy R Hammond

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation

局部钙积累促进皮质神经炎症中吞噬细胞介导的突触清除

Mehrnoosh Jafari #, Adrian-Minh Schumacher #, Nicolas Snaidero #, Emily M Ullrich Gavilanes, Tradite Neziraj, Virág Kocsis-Jutka, Daniel Engels, Tanja Jürgens, Ingrid Wagner, Juan Daniel Flórez Weidinger, Stephanie S Schmidt, Eduardo Beltrán, Nellwyn Hagan, Lisa Woodworth, Dimitry Ofengeim, Joseph G

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

RIPK1激活介导多发性硬化症中的神经炎症和疾病进展

Matija Zelic ,Fabrizio Pontarelli ,Lisa Woodworth ,Cheng Zhu ,Amy Mahan ,Yi Ren ,Michael LaMorte ,Ross Gruber ,Aislinn Keane ,Pequita Loring ,Lilu Guo ,Tai-He Xia ,Boyao Zhang ,Pontus Orning ,Egil Lien ,Alexei Degterev ,Timothy Hammond ,Dimitry Ofengeim

CSF1R signaling is a regulator of pathogenesis in progressive MS

CSF1R信号通路是进行性多发性硬化症发病机制的调节因子。

Nellwyn Hagan ,John L Kane ,Deepak Grover ,Lisa Woodworth ,Charlotte Madore ,Jacqueline Saleh ,Jose Sancho ,Jinyu Liu ,Yi Li ,Jonathan Proto ,Matija Zelic ,Amy Mahan ,Michael Kothe ,Andrew A Scholte ,Maria Fitzgerald ,Barbara Gisevius ,Aiden Haghikia ,Oleg Butovsky ,Dimitry Ofengeim

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner

ABIN-1杂合性以RIPK1依赖性和RIPK1非依赖性两种方式增强对先天免疫反应的敏感性。

Zhenyi Su,Slawomir A Dziedzic,Die Hu,Vica Jean Barrett,Nicole Broekema,Wanjin Li,Lihui Qian,Na Jia,Dimitry Ofengeim,Ayaz Najafov,Hong Zhu,David M Knipe,Junying Yuan

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

TBK1 抑制发育和衰老过程中 RIPK1 驱动的细胞凋亡和炎症

Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li, Bing Shan, Masanori Gomi Naito, Huyan Meng, Ying Li, Heling Pan, Liviu Aron, Xian Adiconis, Joshua Z Levin, Bruce A Yankner, Junying Yuan

Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death

新型自噬抑制剂与 Quizartinib 的协同作用增强癌细胞死亡

Amanda Tomie Ouchida, Yingbo Li, Jiefei Geng, Ayaz Najafov, Dimitry Ofengeim, Xiaoxiao Sun, Qiang Yu, Junying Yuan

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

在 TNFα 介导的细胞凋亡中,一种独特的活化 RIPK1 中间体桥接复合物 I 和复合物 II 的调节

Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim, Slawomir A Dziedzic, Huibing Wang, Vica Jean Barrett, Yasushi Ito, Matthew J LaVoie, Junying Yuan