日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

通过对癫痫网络中心进行基因校正来挽救 16p11.2 重复综合征小鼠模型中的神经精神表型

Marc P Forrest, Marc Dos Santos, Nicolas H Piguel, Yi-Zhi Wang, Nicole A Hawkins, Vikram A Bagchi, Leonardo E Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E Horan, Alfred L George Jr, Mark S LeDoux, Jennifer A Kearney, Jeffrey N Savas, Peter Penzes

Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls

纯合子可能是半合子:iPSC 中的 CRISPR/Cas9 编辑会导致有害的靶向缺陷,从而逃避标准质量控制

Dina Simkin, Vasileios Papakis, Bernabe I Bustos, Christina M Ambrosi, Steven J Ryan, Valeriya Baru, Luis A Williams, Graham T Dempsey, Owen B McManus, John E Landers, Steven J Lubbe, Alfred L George Jr, Evangelos Kiskinis

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

KCNQ2脑病人类神经元模型中Ca2+激活K+通道的稳态调节失调

Dina Simkin,Kelly A Marshall,Carlos G Vanoye,Reshma R Desai,Bernabe I Bustos,Brandon N Piyevsky,Juan A Ortega,Marc Forrest,Gabriella L Robertson,Peter Penzes,Linda C Laux,Steven J Lubbe,John J Millichap,Alfred L George Jr,Evangelos Kiskinis

Cognitive aging is associated with redistribution of synaptic weights in the hippocampus

认知衰老与海马体突触权重的重新分布有关

Eric W Buss, Nicola J Corbett, Joshua G Roberts, Natividad Ybarra, Timothy F Musial, Dina Simkin, Elizabeth Molina-Campos, Kwang-Jin Oh, Lauren L Nielsen, Gelique D Ayala, Sheila A Mullen, Anise K Farooqi, Gary X D'Souza, Corinne L Hill, Linda A Bean, Annalise E Rogalsky, Matthew L Russo, Dani M Cur

Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

CA3 锥体神经元中与衰老相关的过度兴奋是由增强的 A 型 K+ 通道功能和表达介导的

Dina Simkin, Shoai Hattori, Natividad Ybarra, Timothy F Musial, Eric W Buss, Hannah Richter, M Matthew Oh, Daniel A Nicholson, John F Disterhoft