日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition.

Angelman 综合征的临床前猪模型反映了人类疾病的早期发展轨迹

Myers Luke S, Christian Sarah G, Simpson Sean, Sper Renan, Taylor Clint, Montes Laura, Jepp Thomas B C, Ramos Daniela, Schuller Livia, Konganti Kranti, Friedeck Wade, Habib Ozair, Hodge McKaela, Taylor Alasdair J, Coffell Ashley, Schlafer Annalise, Matt Morgan, Revell Bradley, Knight Carol, Barreña Cristina C, Murphy William J, Weeber Edwin J, Segal David J, Anderson Anne, Nash Kevin R, Silverman Jill L, Piedrahita Jorge A, Dindot Scott V

Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice

产前注射治疗性反义寡核苷酸可在小鼠大脑中实现广泛生物分布,并改善 Angelman 综合征表型

Maria T Clarke, Laura Remesal, Lea Lentz, Danielle J Tan, David Young, Slesha Thapa, Shalini R Namuduri, Beltran Borges, Georgia Kirn, Jasmine Valencia, Manuel E Lopez, Jan H Lui, Lawrence R Shiow, Scott Dindot, Saul Villeda, Stephan J Sanders, Tippi C MacKenzie

Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome

泛素蛋白连接酶 E3A 基因全缺失的 Angelman 综合征大鼠模型的早期发育脑电图和癫痫发作表型

Heather A Born, Luis A Martinez, Amber T Levine, Sarah E Harris, Shubhangi Mehra, Wai Ling Lee, Scott V Dindot, Kevin R Nash, Jill L Silverman, David J Segal, Edwin J Weeber, Anne E Anderson

Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits

小脑-前额皮质回路对自闭症相关行为的调节

Kelly, Elyza; Meng, Fantao; Fujita, Hirofumi; Morgado, Felipe; Kazemi, Yasaman; Rice, Laura C; Ren, Chongyu; Escamilla, Christine Ochoa; Gibson, Jennifer M; Sajadi, Sanaz; Pendry, Robert J; Tan, Tommy; Ellegood, Jacob; Basson, M Albert; Blakely, Randy D; Dindot, Scott V; Golzio, Christelle; Hahn, Maureen K; Katsanis, Nicholas; Robins, Diane M; Silverman, Jill L; Singh, Karun K; Wevrick, Rachel; Taylor, Margot J; Hammill, Christopher; Anagnostou, Evdokia; Pfeiffer, Brad E; Stoodley, Catherine J; Lerch, Jason P; du Lac, Sascha; Tsai, Peter T

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

在泛素蛋白连接酶E3A基因完全缺失的Angelman综合征大鼠模型中,转化研究结果

Berg, E L; Pride, M C; Petkova, S P; Lee, R D; Copping, N A; Shen, Y; Adhikari, A; Fenton, T A; Pedersen, L R; Noakes, L S; Nieman, B J; Lerch, J P; Harris, S; Born, H A; Peters, M M; Deng, P; Cameron, D L; Fink, K D; Beitnere, U; O'Geen, H; Anderson, A E; Dindot, S V; Nash, K R; Weeber, E J; Wöhr, M; Ellegood, J; Segal, D J; Silverman, J L

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

构建一种具有完全Ube3a基因缺失的新型Angelman综合征大鼠模型

Dodge, Andie; Peters, Melinda M; Greene, Hayden E; Dietrick, Clifton; Botelho, Robert; Chung, Diana; Willman, Jonathan; Nenninger, Austin W; Ciarlone, Stephanie; Kamath, Siddharth G; Houdek, Pavel; Sumová, Alena; Anderson, Anne E; Dindot, Scott V; Berg, Elizabeth L; O'Geen, Henriette; Segal, David J; Silverman, Jill L; Weeber, Edwin J; Nash, Kevin R

Immune response of human cultured cells towards macrocyclic Fe(2)PO and Fe(2)PC bioactive cyclophane complexes

人类培养细胞对大环Fe(2)PO和Fe(2)PC生物活性环芳烃配合物的免疫反应

Salazar-Medina, Alex J; Velazquez-Contreras, Enrique F; Sugich-Miranda, Rocio; Santacruz, Hisila; Navarro, Rosa E; Rocha-Alonzo, Fernando; Islas-Osuna, Maria A; Chen, Patricia L; Christian, Sarah G B; Romoser, Amelia A; Dindot, Scott V; Sayes, Christie M; Sotelo-Mundo, Rogerio R; Criscitiello, Michael F

Genomic imprinting does not reduce the dosage of UBE3A in neurons

基因组印记不会降低神经元中UBE3A的剂量

Hillman, Paul R; Christian, Sarah G B; Doan, Ryan; Cohen, Noah D; Konganti, Kranti; Douglas, Kory; Wang, Xu; Samollow, Paul B; Dindot, Scott V

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome

Ube3a 亚型 2 的神经元过度表达导致与 15q11.2-q13.3 重复综合征相关的行为障碍和神经解剖病理学

Nycole A Copping, Sarah G B Christian, Dylan J Ritter, M Saharul Islam, Nathalie Buscher, Dorota Zolkowska, Michael C Pride, Elizabeth L Berg, Janine M LaSalle, Jacob Ellegood, Jason P Lerch, Lawrence T Reiter, Jill L Silverman, Scott V Dindot

TRPM2 SNP genotype previously associated with susceptibility to Rhodococcus equi pneumonia in Quarter Horse foals displays differential gene expression identified using RNA-Seq

先前与夸特马幼驹感染马红球菌肺炎易感性相关的TRPM2 SNP基因型,通过RNA-Seq技术鉴定出存在差异基因表达。

McQueen, Cole M; Whitfield-Cargile, Canaan M; Konganti, Kranti; Blodgett, Glenn P; Dindot, Scott V; Cohen, Noah D