日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity

TNF-α 和 IFN-γ 对 AML 细胞对 CD70 抗体介导的细胞毒性的敏感性具有不同的调节作用

Sponheimer, Monika; White, Kieron; Ulrich, Michelle; Kazerani, Maryam; Maiser, Andreas; Tyborski, Emil Thore; Rappa, Giulia Petra; Richter, Daniel; Briem, Eva; Hänel, Gerulf; Philipp, Nora; Nixdorf, Daniel; Rohrbacher, Lisa; Marcinek, Anetta; Linder, Andreas; Kuhl, Niklas; Piseddu, Ignazio; Straub, Tobias; Harz, Hartmann; Wichmann, Christian; Maenner, Denis; Rudelius, Martina; Hornung, Veit; Leonhardt, Heinrich; Van Elssen, Catharina H M J; Abdelhamed, Sherif; Diolaiti, Daniel; Bücklein, Veit; Subklewe, Marion

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo

发现 AVI-6451,一种强效且选择性的 SARS-CoV-2 ADP-核糖水解酶 Mac1 抑制剂,具有口服体内疗效。

Jaishankar, Priyadarshini; Correy, Galen J; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M; Stevens, Maisie G V; Hantz, Eric R; Zheng, Jeffrey; Diolaiti, Morgan E; Montano, Mauricio; Taha, Taha Y; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J; Shoichet, Brian K; Ashworth, Alan; Ott, Melanie; Fraser, James S; Renslo, Adam R

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

对 A20 基因中的单个错义突变进行碱基编辑可增强 CAR-T 细胞的疗效

Blaisdell, Adam; Bachl, Stefanie; Sandoval, Luis R; Ching, Carter; Bowman, Christopher J; Kale, Nupura; Prabandham, Manu; Diolaiti, Morgan; Havig, Claire; Advincula, Rommel; Lenci, Nika; Li, Zhongmei; Yamashita, Emily; Wang, Charlotte H; Zhang, Shimin; Liu, Qi; Achacoso, Philip; Stibor, Dorothea; Øynebråten, Inger; Seo, Jin; Ashworth, Alan; Marson, Alexander; Ye, Chun Jimmie; Malynn, Barbara A; Eyquem, Justin; Carnevale, Julia; Ma, Averil

Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements

组蛋白去甲基化酶 KDM5A 和 KDM5B 通过抑制内源性逆转录病毒元件的转录来调节免疫反应

Huadong Chen, Letitia Sarah, Daniela Pucciarelli, Ying Mao, Morgan E Diolaiti, Danica Galonić Fujimori, Alan Ashworth

The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

Mac1 ADP-核糖基水解酶是 SARS-CoV-2 的治疗靶点

Rahul K Suryawanshi, Priyadarshini Jaishankar, Galen J Correy, Moira M Rachman, Patrick C O'Leary, Taha Y Taha, Francisco J Zapatero-Belinchón, Maria McCavittMalvido, Yagmur U Doruk, Maisie G V Stevens, Morgan E Diolaiti, Manasi P Jogalekar, Alicia L Richards, Mauricio Montano, Julia Rosecrans, Mich

A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies.

基于转录组的精准肿瘤学平台,用于针对多种难治性恶性肿瘤的患者-治疗方案匹配

Mundi Prabhjot S, Dela Cruz Filemon S, Grunn Adina, Diolaiti Daniel, Mauguen Audrey, Rainey Allison R, Guillan Kristina, Siddiquee Armaan, You Daoqi, Realubit Ronald, Karan Charles, Ortiz Michael V, Douglass Eugene F, Accordino Melissa, Mistretta Suzanne, Brogan Frances, Bruce Jeffrey N, Caescu Cristina I, Carvajal Richard D, Crew Katherine D, Decastro Guarionex, Heaney Mark, Henick Brian S, Hershman Dawn L, Hou June Y, Iwamoto Fabio M, Jurcic Joseph G, Kiran Ravi P, Kluger Michael D, Kreisl Teri, Lamanna Nicole, Lassman Andrew B, Lim Emerson A, Manji Gulam A, McKhann Guy M, McKiernan James M, Neugut Alfred I, Olive Kenneth P, Rosenblat Todd, Schwartz Gary K, Shu Catherine A, Sisti Michael B, Tergas Ana, Vattakalam Reena M, Welch Mary, Wenske Sven, Wright Jason D, Canoll Peter, Hibshoosh Hanina, Kalinsky Kevin, Aburi Mahalaxmi, Sims Peter A, Alvarez Mariano J, Kung Andrew L, Califano Andrea

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo

SARS-CoV-2 NSP3 Mac1 结构域中单个失活氨基酸的改变会减弱病毒在体内的复制。

Taha Y Taha,Rahul K Suryawanshi,Irene P Chen,Galen J Correy,Maria McCavitt-Malvido,Patrick C O'Leary,Manasi P Jogalekar,Morgan E Diolaiti,Gabriella R Kimmerly,Chia-Lin Tsou,Ronnie Gascon,Mauricio Montano,Luis Martinez-Sobrido,Nevan J Krogan,Alan Ashworth,James S Fraser,Melanie Ott

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo

SARS-CoV-2 NSP3 Mac1 结构域中的单个失活氨基酸变化可减弱病毒在体内的复制和致病机制

Taha Y Taha, Rahul K Suryawanshi, Irene P Chen, Galen J Correy, Patrick C O'Leary, Manasi P Jogalekar, Maria McCavitt-Malvido, Morgan E Diolaiti, Gabriella R Kimmerly, Chia-Lin Tsou, Luis Martinez-Sobrido, Nevan J Krogan, Alan Ashworth, James S Fraser, Melanie Ott

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

T细胞中RASA2的缺失可增强抗原敏感性和长期功能

Julia Carnevale # ,Eric Shifrut # ,Nupura Kale ,William A Nyberg ,Franziska Blaeschke ,Yan Yi Chen ,Zhongmei Li ,Sagar P Bapat ,Morgan E Diolaiti ,Patrick O'Leary ,Shane Vedova ,Julia Belk ,Bence Daniel ,Theodore L Roth ,Stefanie Bachl ,Alejandro Allo Anido ,Brooke Prinzing ,Jorge Ibañez-Vega ,Shannon Lange ,Dalia Haydar ,Marie Luetke-Eversloh ,Maelys Born-Bony ,Bindu Hegde ,Scott Kogan ,Tobias Feuchtinger ,Hideho Okada ,Ansuman T Satpathy ,Kevin Shannon ,Stephen Gottschalk ,Justin Eyquem ,Giedre Krenciute ,Alan Ashworth ,Alexander Marson