日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase III Randomized Trial of Integrated Genomics and Avatar Models for Personalized Treatment of Pancreatic Cancer: The AVATAR Trial

一项整合基因组学和虚拟化身模型用于胰腺癌个性化治疗的III期随机试验:AVATAR试验

Sarno, Francesca; Tenorio, Jair; Perea, Sofia; Medina, Laura; Pazo-Cid, Roberto; Juez, Ignacio; Garcia-Carbonero, Rocío; Feliu, Jaime; Guillen-Ponce, Carmen; Lopez-Casas, Pedro P; Guerra, Carmen; Duran, Yolanda; López-Acosta, José Francisco; Alonso, Carolina; Esquivel, Estrella; Dopazo, Ana; Akshinthala, Dipikaa; Muthuswamy, Senthil K; Lapunzina, Pablo; Bockorny, Bruno; Hidalgo, Manuel

Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses.

在简化的培养基条件下生长的头颈部肿瘤类器官可以模拟肿瘤生物学和放化疗反应

Li Weilin, Nishino Michiya, Reed Eric, Akshinthala Dipikaa, Pasha Hamdan Ahmed, Anderson Erik S, Huang Ling, Hebestreit Hannah, Monti Stefano, Gomez Ernest D, Jalisi Scharukh M, Muthuswamy Senthil K

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer

建立雌激素受体阳性乳腺癌类器官模型的生成和维持条件

Michael U J Oliphant #, Dipikaa Akshinthala #, Senthil K Muthuswamy

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer.

建立生成和维持雌激素受体阳性乳腺癌类器官模型的条件

Oliphant Michael Uj, Akshinthala Dipikaa, Muthuswamy Senthil K

Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer

类器官敏感性与胰腺癌患者的治疗反应相关

Joseph E Grossman #, Lakshmi Muthuswamy #, Ling Huang #, Dipikaa Akshinthala, Sofia Perea, Raul S Gonzalez, Leo L Tsai, Jonah Cohen, Bruno Bockorny, Andrea J Bullock, Benjamin Schlechter, Mary Linton B Peters, Catherine Conahan, Supraja Narasimhan, Christine Lim, Roger B Davis, Robert Besaw, Mandeep

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

靶向 Pin1 可通过与免疫化疗协同作用使胰腺癌得以根除

Kazuhiro Koikawa ,Shin Kibe ,Futoshi Suizu ,Nobufumi Sekino ,Nami Kim ,Theresa D Manz ,Benika J Pinch ,Dipikaa Akshinthala ,Ana Verma ,Giorgio Gaglia ,Yutaka Nezu ,Shizhong Ke ,Chenxi Qiu ,Kenoki Ohuchida ,Yoshinao Oda ,Tae Ho Lee ,Babara Wegiel ,John G Clohessy ,Nir London ,Sandro Santagata ,Gerburg M Wulf ,Manuel Hidalgo ,Senthil K Muthuswamy ,Masafumi Nakamura ,Nathanael S Gray ,Xiao Zhen Zhou ,Kun Ping Lu

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

人类干细胞衍生的胰腺腺泡和导管类器官的承诺和致癌基因诱导的可塑性

Ling Huang, Ridhdhi Desai, Daniel N Conrad, Nayara C Leite, Dipikaa Akshinthala, Christine Maria Lim, Raul Gonzalez, Lakshmi B Muthuswamy, Zev Gartner, Senthil K Muthuswamy

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids

利用自体胰腺肿瘤类器官对循环中肿瘤靶向T细胞受体进行经验性鉴定和验证

Qingda Meng # ,Shanshan Xie # ,G Kenneth Gray ,Mohammad H Dezfulian ,Weilin Li ,Ling Huang ,Dipikaa Akshinthala ,Elizabeth Ferrer ,Catherine Conahan ,Sofia Perea Del Pino ,Joseph Grossman ,Stephen J Elledge ,Manuel Hidalgo ,Senthil K Muthuswamy

PDX-derived organoids model in vivo drug response and secrete biomarkers

PDX衍生的类器官可模拟体内药物反应并分泌生物标志物

Ling Huang ,Bruno Bockorny ,Indranil Paul ,Dipikaa Akshinthala ,Pierre-Oliver Frappart ,Omar Gandarilla ,Arindam Bose ,Veronica Sanchez-Gonzalez ,Emily E Rouse ,Sylvain D Lehoux ,Nicole Pandell ,Christine M Lim ,John G Clohessy ,Joseph Grossman ,Raul Gonzalez ,Sofia Perea Del Pino ,George Daaboul ,Mandeep S Sawhney ,Steven D Freedman ,Alexander Kleger ,Richard D Cummings ,Andrew Emili ,Lakshmi B Muthuswamy ,Manuel Hidalgo ,Senthil K Muthuswamy

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

使用变构抑制剂靶向 PTP1B 无序 C 端

Navasona Krishnan, Dorothy Koveal, Daniel H Miller, Bin Xue, Sai Dipikaa Akshinthala, Jaka Kragelj, Malene Ringkjøbing Jensen, Carla-Maria Gauss, Rebecca Page, Martin Blackledge, Senthil K Muthuswamy, Wolfgang Peti, Nicholas K Tonks