日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to Cisplatin

采用系统生物学方法研究与三阴性乳腺癌顺铂耐药有关的激酶信号转导网络

Nupur Mukherjee, Alacoque Browne, Laura Ivers, Tapesh Santra, Mattia Cremona, Bryan T Hennessy, Norma O'Donovan, John Crown, Walter Kolch, Dirk Fey, Alex J Eustace

BAX and SMAC regulate bistable properties of the apoptotic caspase system

BAX 和 SMAC 调节凋亡 caspase 系统的双稳态特性

Stephanie McKenna, Lucía García-Gutiérrez, David Matallanas, Dirk Fey

Accurate prediction of kinase-substrate networks using knowledge graphs

使用知识图谱准确预测激酶-底物网络

Vít Nováček, Gavin McGauran, David Matallanas, Adrián Vallejo Blanco, Piero Conca, Emir Muñoz, Luca Costabello, Kamalesh Kanakaraj, Zeeshan Nawaz, Brian Walsh, Sameh K Mohamed, Pierre-Yves Vandenbussche, Colm J Ryan, Walter Kolch, Dirk Fey

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

PP1 启动 MASTL 的去磷酸化,引发人类细胞中有丝分裂退出和双稳态

Samuel Rogers, Dirk Fey, Rachael A McCloy, Benjamin L Parker, Nicholas J Mitchell, Richard J Payne, Roger J Daly, David E James, C Elizabeth Caldon, D Neil Watkins, David R Croucher, Andrew Burgess

Wnt signalling is a bi-directional vulnerability of cancer cells

Wnt 信号是癌细胞的双向脆弱性

David J Duffy, Aleksandar Krstic, Thomas Schwarzl, Melinda Halasz, Kristiina Iljin, Dirk Fey, Bridget Haley, Jenny Whilde, Saija Haapa-Paananen, Vidal Fey, Matthias Fischer, Frank Westermann, Kai-Oliver Henrich, Steffen Bannert, Desmond G Higgins, Walter Kolch

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

信号通路模型作为生物标志物:患者特异性 JNK 活性模拟可预测神经母细胞瘤患者的生存率

Dirk Fey, Melinda Halasz, Daniel Dreidax, Sean P Kennedy, Jordan F Hastings, Nora Rauch, Amaya Garcia Munoz, Ruth Pilkington, Matthias Fischer, Frank Westermann, Walter Kolch, Boris N Kholodenko, David R Croucher

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

整合组学揭示 MYCN 是细胞信号传导的整体抑制因子,并使得基于网络的神经母细胞瘤治疗靶点发现成为可能

David J Duffy, Aleksandar Krstic, Melinda Halasz, Thomas Schwarzl, Dirk Fey, Kristiina Iljin, Jai Prakash Mehta, Kate Killick, Jenny Whilde, Benedetta Turriziani, Saija Haapa-Paananen, Vidal Fey, Matthias Fischer, Frank Westermann, Kai-Oliver Henrich, Steffen Bannert, Desmond G Higgins, Walter Kolch

Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2

假磷酸酶 STYX 通过时空调节 ERK1/2 来调节细胞命运决定和细胞迁移

Veronika Reiterer, Dirk Fey, Walter Kolch, Boris N Kholodenko, Hesso Farhan