日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models

经基因工程改造的结核分枝杆菌三重杀菌开关菌株可在动物模型中实现可控的结核病感染

Xin Wang # ,Hongwei Su # ,Joshua B Wallach # ,Jeffrey C Wagner # ,Benjamin J Braunecker ,Michelle Gardner ,Kristine M Guinn ,Nicole C Howard ,Thais Klevorn ,Kan Lin ,Yue J Liu ,Yao Liu ,Douaa Mugahid ,Mark Rodgers ,Jaimie Sixsmith ,Shoko Wakabayashi ,Junhao Zhu ,Matthew Zimmerman ,Véronique Dartois ,JoAnne L Flynn ,Philana Ling Lin ,Sabine Ehrt ,Sarah M Fortune ,Eric J Rubin ,Dirk Schnappinger

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

多模态测量的整合揭示了结核病药物作用的关键机制

William C Johnson ,Ares Alivisatos ,Trever C Smith 2nd ,Nhi Van ,Vijay Soni ,Joshua B Wallach ,Nicholas A Clark ,Timothy A Fitzgerald ,Joshua J Whiteley ,Shumin Tan ,Artem Sokolov ,D Michael Ando ,Dirk Schnappinger ,Kyu Y Rhee ,Bree B Aldridge

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

分枝杆菌生物素合酶需要辅助蛋白将脱硫生物素转化为生物素

Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger

CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis

CpsA介导结核分枝杆菌对募集的肺髓系细胞的感染

Steven J Grigsby ,G V R Krishna Prasad ,Joshua B Wallach ,Ekansh Mittal ,Fong-Fu Hsu ,Dirk Schnappinger ,Jennifer A Philips

Interruption of mycothiol synthesis and intracellular redox status impact iron-regulated reporter activation in Mycobacterium smegmatis

中断菌硫醇合成和细胞内氧化还原状态影响结核分枝杆菌铁调节报告基因的激活

Alexandra H Miller, Frances Marks, Luming Chan, Helene Botella, Dirk Schnappinger, Sabine Ehrt

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

“自杀” BCG 菌株可增强恒河猴的免疫原性,并为其提供针对结核分枝杆菌的强大保护

Alexander A Smith, Hongwei Su, Joshua Wallach, Yao Liu, Pauline Maiello, H Jacob Borish, Caylin Winchell, Andrew W Simonson, Philana Ling Lin, Mark Rodgers, Daniel Fillmore, Jennifer Sakal, Kan Lin, Valerie Vinette, Dirk Schnappinger, Sabine Ehrt, JoAnne L Flynn

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

环磷酸腺苷是结核分枝杆菌内在耐药性和脂肪酸代谢的关键介质

Andrew I Wong, Tiago Beites, Kyle A Planck, Rachael A Fieweger, Kathryn A Eckartt, Shuqi Li, Nicholas C Poulton, Brian C VanderVen, Kyu Y Rhee, Dirk Schnappinger, Sabine Ehrt, Jeremy Rock

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

CRISPRi 化学遗传学和比较基因组学鉴定出介导结核分枝杆菌药物效力的基因

Shuqi Li #, Nicholas C Poulton #, Jesseon S Chang, Zachary A Azadian, Michael A DeJesus, Nadine Ruecker, Matthew D Zimmerman, Kathryn A Eckartt, Barbara Bosch, Curtis A Engelhart, Daniel F Sullivan, Martin Gengenbacher, Véronique A Dartois, Dirk Schnappinger, Jeremy M Rock

CinA mediates multidrug tolerance in Mycobacterium tuberculosis

CinA 介导结核分枝杆菌的多药耐药性

Kaj M Kreutzfeldt, Robert S Jansen, Travis E Hartman, Alexandre Gouzy, Ruojun Wang, Inna V Krieger, Matthew D Zimmerman, Martin Gengenbacher, Jansy P Sarathy, Min Xie, Véronique Dartois, James C Sacchettini, Kyu Y Rhee, Dirk Schnappinger, Sabine Ehrt

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

具有强效和选择性抗结核活性的螺嘧啶三酮 DNA 旋转酶抑制剂

Preshendren Govender, Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J Eyermann, Stephen Fienberg, Sandeep R Ghorpade, Lizbé Koekemoer, Alissa Myrick, Dirk Schnappinger, Curtis Engelhart, Jaclynn Meshanni, Jo Ann W Byl, Neil Osheroff, Vinayak Singh, Kelly Chibale, Gregory S Basarab