Two distinct protein-protein interfaces drive cooperative binding of the herpes simplex virus protein ICP8 to ssDNA, filament formation and annealing essential for viral replication.

两种不同的蛋白质-蛋白质界面驱动单纯疱疹病毒蛋白 ICP8 与 ssDNA 的协同结合、丝状体形成和退火，这对病毒复制至关重要