日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent RNA Modulation

机制明确的环氧化物和氮丙啶-2-甲酰胺亲电试剂可实现立体选择性共价RNA调控

Li, Chungen; Yang, Xueyi; Shan, Jingsong; Dickerson, Kyle A; Springer, Noah A; Munshi, Nikhil C; Batey, Robert T; Disney, Matthew D

Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch

基于结构的生物活性共价小分子设计,靶向核糖开关

Li, Chungen; Yang, Xueyi; Dickerson, Kyle A; Zanon, Patrick R A; Springer, Noah A; Wang, Jielei; Jia, Yilin; Munshi, Nikhil C; Batey, Robert T; Disney, Matthew D

Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders

RNA反应性小分子的发现指导了RNA特异性共价结合剂亲电模块的设计

Springer, Noah A; Zanon, Patrick R A; Taghavi, Amirhossein; Sung, Kisu; Disney, Matthew D

Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation

无偏倚的RNA降解酶鉴定揭示了一种LC3B募集嵌合体,用于降解COL15A1 mRNA

Su, Xiaoxuan; Tong, Yuquan; Zanon, Patrick R A; Wang, Jielei; Tanaka, Toru; Childs-Disney, Jessica L; Disney, Matthew D

Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design

共价探针揭示结构化RNA中的小分子结合口袋,并实现生物活性化合物的设计

Kovachka, Sandra; Wang, Jielei; Taghavi, Amirhossein; Jia, Yilin; Asaba, Taro; Wolff, Karen C; Martin, Mason; Yang, Xueyi; Meyer, Samantha M; Ottilie, Sabine; Heacock, Mina; Cheng, Zhong; McNamara, Case W; Dubey, Gurudutt; Chatterjee, Arnab K; Chanda, Sumit; Gallego, José; Childs-Disney, Jessica L; Disney, Matthew D

Chemical Tagging of N-Alkylamine-Containing Natural Products and Pharmaceuticals through C(sp(3))-H Functionalization

通过 C(sp(3))-H 官能化对含 N-烷基胺的天然产物和药物进行化学标记

Wang, Yuankai; Zhao, Cunyuan; Wang, Tenghui; Steele, Andrew; Joshi, Manas; Mori, Soichiro; Chatterjee, Abhishek; Shen, Ben; Disney, Matthew D; Wasa, Masayuki

A Live-Cell NanoBRET Assay to Monitor RNA-Protein Interactions and Their Inhibition by Small Molecules

一种用于监测RNA-蛋白质相互作用及其被小分子抑制的活细胞NanoBRET检测方法

Shan, Jingsong; Taghavi, Amirhossein; Caine, Elizabeth A; Sekioka, Ryuichi; Rajchin, Veronika; Burke, James M; Watkins, J Monty; Childs-Disney, Jessica L; Disney, Matthew D

Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models.

连接子优化增强了核糖核酸酶靶向嵌合体在癌症模型中的效力

Meyer Samantha M, Kovachka Sandra, Wang Tenghui, Cameron Michael D, Childs-Disney Jessica L, Disney Matthew D

eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis

eNAMPT是人和小鼠肺纤维化中的一种新型DAMP和治疗靶点

Casanova, Nancy G; Herazo-Maya, Jose D; Kempf, Carrie L; Sun, Belinda L; Song, Jin H; Hernandez, Annie; Canizales Galaviz, Jason; Sun, Xiaoguang; Camp, Sara M; Ledford, Julie G; Hellinger, Riley D; Rodriguez, Marisela; Zhao, Amy Y; Unterman, Avraham; Rosas, Ivan; Duncan, Steve; Thannikal, Victor J; Hufford, Matthew K; Ahmed, Mohamed; Zaghloul, Nahla; Gupta, Akash; Bime, Christian; Sammani, Saad; Stansfield, Ben N; Chen, Jinjing; Anandhan, Annadurai; Disney, Matthew D; Ooi, Aikseng; Kee, Shaira L; Karampitsakos, Theodoros; Benos, Panayiotis V; Kaminski, Naftali; Zhang, Donna; Garcia, Joe G N

Streamlined Fragment-Based Discovery Platform for Targeting Structured RNAs

用于靶向结构化RNA的精简型基于片段的发现平台

Jia, Yilin; Taghavi, Amirhossein; Zanon, Patrick R A; Disney, Matthew D