Biological Analysis of Human Immunodeficiency Virus Type 1 R5 Envelopes Amplified from Brain and Lymph Node Tissues of AIDS Patients with Neuropathology Reveals Two Distinct Tropism Phenotypes and Identifies Envelopes in the Brain That Confer an Enhanced Tropism and Fusigenicity for Macrophages
对从患有神经病理学的艾滋病患者的脑和淋巴结组织中扩增的人类免疫缺陷病毒1型R5包膜进行生物学分析,揭示了两种不同的嗜性表型,并鉴定出脑内赋予巨噬细胞增强嗜性和融合性的包膜。
期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-83259-w
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine; Rockenstein, Edward; Mante, Michael; Adame, Anthony; Cook, Jonathan; Jin, Xin; Masliah, Eliezer; Lee, Kuo-Fen; Peters, Paul J; Bhattacharya, Jayanta; Hibbitts, Samantha; Dittmar, Matthias T; Simmons, Graham; Bell, Jeanne; Simmonds, Peter; Clapham, Paul R
巨噬细胞
HIV
巨噬细胞
神经科学
微生物学
Human
细胞生物学
免疫/内分泌