日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

联合使用抗PD-1和抗CTLA-4疗法可产生多波克隆反应,其中包括祖细胞耗竭的CD8+ T细胞。

Kevin Wang ,Paulina Coutifaris ,David Brocks ,Guanning Wang ,Tarek Azar ,Sabrina Solis ,Ajeya Nandi ,Shaneaka Anderson ,Nicholas Han ,Sasikanth Manne ,Evgeny Kiner ,Chirag Sachar ,Minke Lucas ,Sangeeth George ,Patrick K Yan ,Melanie W Kier ,Amy I Laughlin ,Shawn Kothari ,Josephine Giles ,Divij Mathew ,Reem Ghinnagow ,Cecile Alanio ,Ahron Flowers ,Wei Xu ,Daniel J Tenney ,Xiaowei Xu ,Ravi K Amaravadi ,Giorgos C Karakousis ,Lynn M Schuchter ,Marcus Buggert ,Derek Oldridge ,Andy J Minn ,Christian Blank ,Jeffrey S Weber ,Tara C Mitchell ,Michael D Farwell ,Ramin S Herati ,Alexander C Huang

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

非小细胞肺癌获得性免疫治疗耐药的临床和分子特征

Danish Memon ,Adam J Schoenfeld ,Darwin Ye ,George Fromm ,Hira Rizvi ,Xiang Zhang ,Mohamed Reda Keddar ,Divij Mathew ,Kyung Jin Yoo ,Jingya Qiu ,Jayon Lihm ,Jayalaksmi Miriyala ,Jennifer L Sauter ,Jia Luo ,Andrew Chow ,Umesh K Bhanot ,Caroline McCarthy ,Chad M Vanderbilt ,Cailian Liu ,Mohsen Abu-Akeel ,Andrew J Plodkowski ,Nicholas McGranahan ,Marta Łuksza ,Benjamin D Greenbaum ,Taha Merghoub ,Ikbel Achour ,J Carl Barrett ,Ross Stewart ,Pedro Beltrao ,Taylor H Schreiber ,Andy J Minn ,Martin L Miller ,Matthew D Hellmann

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

LAG-3 维持 TOX 表达并调节 CD94/NKG2-Qa-1b 轴,从而控制耗竭 CD8 T 细胞 NK 受体的表达和细胞毒性。

Shin Foong Ngiow ,Sasikanth Manne ,Yinghui Jane Huang ,Tarek Azar ,Zeyu Chen ,Divij Mathew ,Qingzhou Chen ,Omar Khan ,Jennifer E Wu ,Victor Alcalde ,Ahron J Flowers ,Sean McClain ,Amy E Baxter ,Makoto Kurachi ,Junwei Shi ,Alexander C Huang ,Josephine R Giles ,Arlene H Sharpe ,Dario A A Vignali ,E John Wherry

Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients

JAK 抑制和 PD-1 免疫治疗联合治疗非小细胞肺癌患者

Divij Mathew #, Melina E Marmarelis #, Caitlin Foley, Joshua M Bauml, Darwin Ye, Reem Ghinnagow, Shin Foong Ngiow, Max Klapholz, Soyeong Jun, Zhaojun Zhang, Robert Zorc, Christiana W Davis, Maximillian Diehn, Josephine R Giles, Alexander C Huang, Wei-Ting Hwang, Nancy R Zhang, Adam J Schoenfeld, Eri

Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

Stat5 拮抗转录因子 Tox,并在慢性抗原暴露期间将耗竭的 CD8+ T 细胞重塑为持久的效应样状态。

Jean-Christophe Beltra ,Mohamed S Abdel-Hakeem ,Sasikanth Manne ,Zhen Zhang ,Hua Huang ,Makoto Kurachi ,Leon Su ,Lora Picton ,Shin Foong Ngiow ,Yuki Muroyama ,Valentina Casella ,Yinghui J Huang ,Josephine R Giles ,Divij Mathew ,Jonathan Belman ,Max Klapholz ,Hélène Decaluwe ,Alexander C Huang ,Shelley L Berger ,K Christopher Garcia ,E John Wherry

Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis

COVID-19 和非 COVID-19 脓毒症脂质组学反应的深度表型分析

Hu Meng, Arjun Sengupta, Emanuela Ricciotti, Antonijo Mrčela, Divij Mathew, Liudmila L Mazaleuskaya, Soumita Ghosh, Thomas G Brooks, Alexandra P Turner, Alessa Soares Schanoski, Nicholas F Lahens, Ai Wen Tan, Ashley Woolfork, Greg Grant, Katalin Susztak, Andrew G Letizia, Stuart C Sealfon, E John Wh

Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs

非甾体抗炎药对严重急性呼吸道综合征冠状病毒 2 疫苗接种的免疫反应的调节

Carsten Skarke, Ronan Lordan, Kayla Barekat, Amruta Naik, Divij Mathew, Takuya Ohtani, Allison R Greenplate, Gregory R Grant, Nicholas F Lahens, Sigrid Gouma, Elizabeth Troisi, Arjun Sengupta, Aalim M Weljie, Wenzhao Meng, Eline T Luning Prak, Kendall Lundgreen, Paul Bates, Hu Meng, Garret A FitzGer

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

先前接种疫苗可增强 SARS-CoV-2 突破性感染期间的免疫反应,通过早期激活记忆 T 细胞,随后产生有效的中和抗体

Mark M Painter, Timothy S Johnston, Kendall A Lundgreen, Jefferson J S Santos, Juliana S Qin, Rishi R Goel, Sokratis A Apostolidis, Divij Mathew, Bria Fulmer, Justine C Williams, Michelle L McKeague, Ajinkya Pattekar, Ahmad Goode, Sean Nasta, Amy E Baxter, Josephine R Giles, Ashwin N Skelly, Laura E

Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

时间单细胞转录组学和表观遗传学揭示效应、记忆和耗竭 CD8+ T 细胞中共享和不同的生物回路

Josephine R Giles, Shin Foong Ngiow, Sasikanth Manne, Amy E Baxter, Omar Khan, Ping Wang, Ryan Staupe, Mohamed S Abdel-Hakeem, Hua Huang, Divij Mathew, Mark M Painter, Jennifer E Wu, Yinghui Jane Huang, Rishi R Goel, Patrick K Yan, Giorgos C Karakousis, Xiaowei Xu, Tara C Mitchell, Alexander C Huang

SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations

与 SARS-CoV-2 mRNA 疫苗相比,SARS-CoV-2 感染可引发更高水平的原始抗原抗体

Elizabeth M Anderson, Shuk Hang Li, Moses Awofolaju, Theresa Eilola, Eileen Goodwin, Marcus J Bolton, Sigrid Gouma, Tomaz B Manzoni, Philip Hicks, Rishi R Goel, Mark M Painter, Sokratis A Apostolidis, Divij Mathew, Debora Dunbar, Danielle Fiore, Amanda Brock, JoEllen Weaver, John S Millar, Stephanie