日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia

口服生物可利用的 GSPT1/2 降解剂 SJ6986 在急性淋巴细胞白血病中表现出体内疗效

Yunchao Chang, Fatemeh Keramatnia, Pankaj S Ghate, Gisele Nishiguchi, Qingsong Gao, Ilaria Iacobucci, Lei Yang, Divyabharathi Chepyala, Ashutosh Mishra, Anthony A High, Hiroaki Goto, Koshi Akahane, Junmin Peng, Jun J Yang, Marcus Fischer, Zoran Rankovic, Charles G Mullighan

Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia

蛋白水解靶向 LCK 作为 T 细胞急性淋巴细胞白血病治疗方法的临床前评估

Jianzhong Hu, Jamie Jarusiewicz, Guoqing Du, Gisele Nishiguchi, Satoshi Yoshimura, John C Panetta, Zhenhua Li, Jaeki Min, Lei Yang, Divyabharathi Chepyala, Marisa Actis, Noemi Reyes, Brandon Smart, Ching-Hon Pui, David T Teachey, Zoran Rankovic, Jun J Yang

Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia

CRLF2 重排急性淋巴细胞白血病中 Janus 激酶的降解

Yunchao Chang, Jaeki Min, Jamie A Jarusiewicz, Marisa Actis, Shanshan Yu-Chen Bradford, Anand Mayasundari, Lei Yang, Divyabharathi Chepyala, Lisa J Alcock, Kathryn G Roberts, Stanley Nithianantham, Dylan Maxwell, Lauren Rowland, Randolph Larsen, Aman Seth, Hiroaki Goto, Toshihiko Imamura, Koshi Akah

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

从聚焦的 Cereblon 调节剂库中鉴定高效、选择性强且口服生物利用度高的小分子 GSPT1/2 降解剂

Gisele Nishiguchi,Fatemeh Keramatnia,Jaeki Min,Yunchao Chang,Barbara Jonchere,Sourav Das,Marisa Actis,Jeanine Price,Divyabharathi Chepyala,Brandon Young,Kevin McGowan,P Jake Slavish,Anand Mayasundari,Jamie A Jarusiewicz,Lei Yang,Yong Li,Xiang Fu,Shalandus H Garrett,James B Papizan,Kiran Kodali,Junmin Peng,Shondra M Pruett Miller,Martine F Roussel,Charles Mullighan,Marcus Fischer,Zoran Rankovic