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日期影响因子

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction

自噬是NAD+前体烟酰胺在肥胖相关性射血分数保留型心力衰竭中发挥治疗作用所必需的。

期刊:European Heart Journal

影响因子:35.6

doi:10.1093/eurheartj/ehaf062

Abdellatif, Mahmoud; Vasques-Nóvoa, Francisco; Trummer-Herbst, Viktoria; Durand, Sylvère; Koser, Franziska; Islam, Moydul; Nah, Jihoon; Sung, Eun-Ah; Feng, Ruli; Aprahamian, Fanny; Prokesch, Andreas; Zardoya-Laguardia, Pablo; Sadoshima, Junichi; Diwan, Abhinav; Linke, Wolfgang A; Ferreira, João Pedro; Kroemer, Guido; Sedej, Simon

发表日期：2025

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NAD(+) repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling

NAD(+) 的补充可通过抑制过度营养信号传导，恢复肥胖相关性心力衰竭中的心脏保护性自噬和线粒体自噬。

期刊:Autophagy

影响因子:14.3

doi:10.1080/15548627.2025.2522127

Abdellatif, Mahmoud; Vasques-Nóvoa, Francisco; Ferreira, João Pedro; Sadoshima, Junichi; Diwan, Abhinav; Linke, Wolfgang A; Kroemer, Guido; Sedej, Simon

发表日期：2025

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Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy

在应激诱导心肌病模型中，Toll样受体4可诱导心脏产生训练性先天免疫耐受。

期刊:Cardiovascular Research

影响因子:13.3

doi:10.1093/cvr/cvaf158

Lim, Kenji Rowel Q; Amrute, Junedh; Kovacs, Attila; Diwan, Abhinav; Williams, David L; Mann, Douglas L

免疫/内分泌

发表日期：2025

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Restoration of pancreatic beta cell identity and autophagy in K(ATP)-induced diabetes by intermittent fasting

间歇性禁食恢复K(ATP)诱导糖尿病中胰岛β细胞的特性和自噬

期刊:Diabetologia

影响因子:10.2

doi:10.1007/s00125-025-06545-w

Castelblanco, Esmeralda; Shyr, Zeenat A; Ramirez-Sotero, Irving; Yan, Zihan; Chen, Sophia X; Diwan, Abhinav; Remedi, Maria S

细胞生物学

发表日期：2025

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Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF

针对脂肪组织代谢的特异性治疗优于热量限制，能更有效地治疗肥胖相关的射血分数保留型心力衰竭（HFpEF）。

期刊:Cardiovascular Diabetology

doi:10.1186/s12933-025-02879-2

Sedej, Simon; Stockner, Alina; Schreiber, Renate; Diwan, Abhinav; Breinbauer, Rolf; Abdellatif, Mahmoud

发表日期：2025

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Comparative analysis of isoproterenol- and lipopolysaccharide-mediated cytoprotective responses in the heart

异丙肾上腺素和脂多糖介导的心脏细胞保护反应的比较分析

期刊:American Journal of Physiology-Heart and Circulatory Physiology

doi:10.1152/ajpheart.00594.2025

Lim, Kenji Rowel Q; Amrute, Junedh; Diwan, Abhinav; Mann, Douglas L

细胞生物学

免疫/内分泌

发表日期：2025

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A Micro-Engineered Heart Tissue Model of Desmin-related Cardiomyopathy Caused by Mutant Î±B Crystallin.

由突变αB晶状体蛋白引起的结蛋白相关心肌病的微工程心脏组织模型。

doi:10.1101/2025.10.02.680018

Kargar Gaz Kooh Yasaman, Bahmani Bahareh, Zhao Chen, Malayath Ganesh, Hayem Leah, Jin Hanxun, Ramahdita Ghiska, Jiang Huanzhu, Santiago Perez Javier, Chou Hsin Yi, Ma Xiucui, Genin Guy M, Rawnsley David, Diwan Abhinav, Huebsch Nathaniel

发表日期：2025

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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

溶酶体LRRC8复合物调节溶酶体pH值、形态和全身葡萄糖代谢

doi:10.1101/2024.09.22.614256

Kumar, Ashutosh; Zhao, Yonghui; Xie, Litao; Chadda, Rahul; Abraham, Nihil; Hong, Juan; Feng, Ethan; Tranter, John D; Rawnsley, David; Liu, Haiyan; Henry, Kyla M; Meyer, Gretchen; Hu, Meiqin; Xu, Haoxing; Hinton, Antentor; Grueter, Chad E; Abel, E Dale; Norris, Andrew W; Diwan, Abhinav; Sah, Rajan

发表日期：2024

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Lipopolysaccharide Induces Trained Innate Immune Tolerance in the Heart Through Interferon Signaling in a Model of Stress-Induced Cardiomyopathy

脂多糖通过干扰素信号通路在应激诱导心肌病模型中诱导心脏的训练性先天免疫耐受。

doi:10.1101/2024.09.24.614798

Lim, Kenji Rowel Q; Amrute, Junedh; Kovacs, Attila; Diwan, Abhinav; Williams, David L; Mann, Douglas L

免疫/内分泌

发表日期：2024

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The Case for Restoring Organelles to Treat Ischemic Cardiomyopathy: Is DEPP1 an Attractive Target?

修复细胞器以治疗缺血性心肌病的案例：DEPP1 是一个有吸引力的靶点吗？

期刊:Circulation

doi:10.1161/CIRCULATIONAHA.124.070750

细胞生物学

发表日期：2024

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