日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

一种口服、可渗透大脑的小分子通过增强伪外显子的插入来降低亨廷顿蛋白的水平

Caroline Gubser Keller #, Youngah Shin #, Alex Mas Monteys #, Nicole Renaud, Martin Beibel, Natalia Teider, Thomas Peters, Thomas Faller, Sophie St-Cyr, Judith Knehr, Guglielmo Roma, Alejandro Reyes, Marc Hild, Dmitriy Lukashev, Diethilde Theil, Natalie Dales, Jang-Ho Cha, Beth Borowsky, Ricardo Dol

Regulated control of gene therapies by drug-induced splicing

通过药物诱导剪接调控基因治疗

Alex Mas Monteys, Amiel A Hundley, Paul T Ranum, Luis Tecedor, Amy Muehlmatt, Euyn Lim, Dmitriy Lukashev, Rajeev Sivasankaran, Beverly L Davidson

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

全身氧合削弱缺氧和缺氧诱导因子1α依赖性和细胞外腺苷介导的肿瘤保护作用

Stephen M Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Bryan Belikoff, Taylor H Schreiber, Shalini Sethumadhavan, Robert Abbott, Phaethon Philbrook, Molly Thayer, Dai Shujia, Scott Rodig, Jeffrey L Kutok, Jin Ren, Akio Ohta, Eckhard R Podack, Barry Karger, Edwin K Jackson, Michail Sitkovsky

Genetic deletion of the HIF-1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model

细胞中 HIF-1α 同工型 I.1 的基因缺失可增强抗菌免疫力并提高小鼠腹膜炎模型的生存率

Peter Georgiev, Bryan G Belikoff, Stephen Hatfield, Akio Ohta, Michail V Sitkovsky, Dmitriy Lukashev

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

平衡核苷转运体 1 (ENT1) 调节小鼠急性肾损伤期间的缺血后血流

Almut Grenz, Jessica D Bauerle, Julee H Dalton, Douglas Ridyard, Alexander Badulak, Eunyoung Tak, Eóin N McNamee, Eric Clambey, Radu Moldovan, German Reyes, Jost Klawitter, Kelly Ambler, Kristann Magee, Uwe Christians, Kelley S Brodsky, Katya Ravid, Doo-Sup Choi, Jiaming Wen, Dmitriy Lukashev, Micha