日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer

整合蛋白质基因组学和正向遗传学揭示三阴性乳腺癌中一种新的有丝分裂脆弱性

Nicholas J Neill # ,Shankha Satpathy # ,Karsten Krug ,Jitendra K Meena ,Nivetha Ramesh Babu ,Cheyenne Calderon ,Desmon Reed ,Marcus J Weber ,Lacey E Dobrolecki ,Alaina Lewis ,Christina Sallas ,Meenakshi Anurag ,Kimberly R Holloway ,Chen Huang ,Suhas Vasaikar ,Maria F Cardenas ,Beom-Jun Kim ,Doug W Chan ,Shayan C Avanessian ,Siddhartha Tyagi ,Mayra Orellana ,Sufeng Mao ,Heyuan Li ,Fade Gong ,Sarah J Kurley ,Kristen L Meerbrey ,Calla M Olson ,Amritha Nair ,Tingting Sun ,Hsiang-Ching Chung ,Elizabeth A Bowling ,Jarey H Wang ,Pengju Zhang ,Peng Xiao ,Duxiao Yang ,Fabio Stossi ,Mei-Yin C Polley ,Alexander B Saltzman ,Filip Mundt ,D R Mani ,Michael A Gillette ,Susan G Hilsenbeck ,George Miles ,Carolina Gutierrez ,C Kent Osborne ,Charles Y Lin ,Nathanael S Gray ,Jinpeng Sun ,David A Wheeler ,Charles M Perou ,Anna Malovannaya ,Michael T Lewis ,Bing Zhang ,Matthew J Ellis ,Steven A Carr ,Thomas F Westbrook

Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor-Initiating Cells Characterized by IFN/STAT1 Activity

谱系追踪和单细胞RNA测序揭示了乳腺癌肿瘤起始细胞中一种共同的转录状态,该状态以IFN/STAT1活性为特征。

Eric P Souto ,Ping Gong ,John D Landua ,Ramakrishnan Rajaram Srinivasan ,Abhinaya Ganesan ,Lacey E Dobrolecki ,Stephen C Purdy ,Xingxin Pan ,Michael Zeosky ,Anna Chung ,S Stephen Yi ,Heide L Ford ,Michael T Lewis

ZP4: A novel target for CAR-T cell therapy in triple negative breast cancer

ZP4:三阴性乳腺癌CAR-T细胞疗法的新靶点

Lauren K Somes ,Jonathan T Lei ,Xinpei Yi ,Diego F Chamorro ,Paul Shafer ,Ahmed Z Gad ,Lacey E Dobrolecki ,Emily Madaras ,Nabil Ahmed ,Michael T Lewis ,Bing Zhang ,Valentina Hoyos

Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

双胍类药物通过剂量依赖性的线粒体重编程驱动的c-Src通路,反向调节肿瘤特性。

Jun Hyoung Park,Kwang Hwa Jung,Dongya Jia,Sukjin Yang,Kuldeep S Attri,Songyeon Ahn,Divya Murthy,Tagari Samanta,Debasmita Dutta,Meron Ghidey,Somik Chatterjee,Seung Yeop Han,Diego A Pedroza,Abha Tiwari,Joyce V Lee,Caitlin Davis,Shuting Li,Vasanta Putluri,Chad J Creighton,Nagireddy Putluri,Lacey E Dobrolecki,Michael T Lewis,Jeffrey M Rosen,José N Onuchic,Andrei Goga,Benny Abraham Kaipparettu

Proteogenomic characterization unveils biomarkers associated with chemoresistance in muscle-invasive bladder cancer

蛋白质基因组学特征分析揭示了与肌层浸润性膀胱癌化疗耐药相关的生物标志物

Matthew V Holt ,Yongchao Dou ,Meggie N Young ,Alexander B Saltzman ,Meenakshi Anurag ,Jonathan T Lei ,Antrix Jain ,Mei Leng ,Beom-Jun Kim ,Lacey E Dobrolecki ,Stefanie F Faucher ,Sara Savage ,Chenwei Wang ,Zhiao Shi ,Hugo Villanueva ,Karoline Kremers ,Kyle D Drinnon ,Patricia D Castro ,Michael M Ittmann ,Mehak Mehboob Khatani ,Sung Han Kim ,Matthew J Ellis ,Bing Zhang ,Anna Malovannaya ,Seth P Lerner

Co-Targeting BCL-xL with MCL-1 Induces Lethal Mitochondrial Dysfunction in Diffuse Mesothelioma

BCL-xL 与 MCL-1 联合靶向可诱导弥漫性间皮瘤中致命的线粒体功能障碍

Xu, Yuan; Medina, Cristian G; Surman, Deborah R; Dobrolecki, Lacey E; Vilchis, Monica; Ramineni, Maheshwari; Hilsenbeck, Susan G; Li, Yanming; Li, Naren; Wu, Siqi; Aggison, Jaylon C; Chen, Xi; Zhu, Yi; Shen, Ying H; Ripley, R Taylor

Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses.

源自患者的三阴性乳腺癌异种移植模型能够对化疗反应进行解卷积和预测

Lei Jonathan T, Dobrolecki Lacey E, Huang Chen, Srinivasan Ramakrishnan R, Vasaikar Suhas V, Lewis Alaina N, Sallas Christina, Zhao Na, Cao Jin, Landua John D, Moon Chang In, Liao Yuxing, Hilsenbeck Susan G, Osborne C Kent, Rimawi Mothaffar F, Ellis Matthew J, Petrosyan Varduhi, Wen Bo, Li Kai, Saltzman Alexander B, Jain Antrix, Malovannaya Anna, Wulf Gerburg M, Marangoni Elisabetta, Li Shunqiang, Kraushaar Daniel C, Wang Tao, Damodaran Senthil, Zheng Xiaofeng, Meric-Bernstam Funda, Echeverria Gloria V, Anurag Meenakshi, Chen Xi, Welm Bryan E, Welm Alana L, Zhang Bing, Lewis Michael T

IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer

IRE1α通过沉默dsRNA来阻止紫杉烷类药物诱导的三阴性乳腺癌细胞焦亡

Longyong Xu ,Fanglue Peng ,Qin Luo ,Yao Ding ,Fei Yuan ,Liting Zheng ,Wei He ,Sophie S Zhang ,Xin Fu ,Jin Liu ,Ayse Sena Mutlu ,Shuyue Wang ,Ralf Bernd Nehring ,Xingyu Li ,Qianzi Tang ,Catherine Li ,Xiangdong Lv ,Lacey E Dobrolecki ,Weijie Zhang ,Dong Han ,Na Zhao ,Eric Jaehnig ,Jingyi Wang ,Weiche Wu ,Davis A Graham ,Yumei Li ,Rui Chen ,Weiyi Peng ,Yiwen Chen ,Andre Catic ,Zhibin Zhang ,Bing Zhang ,Anthony M Mustoe ,Albert C Koong ,George Miles ,Michael T Lewis ,Meng C Wang ,Susan M Rosenberg ,Bert W O'Malley ,Thomas F Westbrook ,Han Xu ,Xiang H-F Zhang ,C Kent Osborne ,Jin Billy Li ,Matthew J Ellis ,Mothaffar F Rimawi ,Jeffrey M Rosen ,Xi Chen

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

一个包含基因组和病理注释的泛癌患者来源异种移植组织学图像库可实现深度学习分析

White, Brian S; Woo, Xing Yi; Koc, Soner; Sheridan, Todd; Neuhauser, Steven B; Wang, Shidan; Evrard, Yvonne A; Chen, Li; Foroughi Pour, Ali; Landua, John D; Mashl, R Jay; Davies, Sherri R; Fang, Bingliang; Raso, Maria Gabriela; Evans, Kurt W; Bailey, Matthew H; Chen, Yeqing; Xiao, Min; Rubinstein, Jill C; Sanderson, Brian J; Lloyd, Michael W; Domanskyi, Sergii; Dobrolecki, Lacey E; Fujita, Maihi; Fujimoto, Junya; Xiao, Guanghua; Fields, Ryan C; Mudd, Jacqueline L; Xu, Xiaowei; Hollingshead, Melinda G; Jiwani, Shahanawaz; Acevedo, Saul; Davis-Dusenbery, Brandi N; Robinson, Peter N; Moscow, Jeffrey A; Doroshow, James H; Mitsiades, Nicholas; Kaochar, Salma; Pan, Chong-Xian; Carvajal-Carmona, Luis G; Welm, Alana L; Welm, Bryan E; Govindan, Ramaswamy; Li, Shunqiang; Davies, Michael A; Roth, Jack A; Meric-Bernstam, Funda; Xie, Yang; Herlyn, Meenhard; Ding, Li; Lewis, Michael T; Bult, Carol J; Dean, Dennis A 2nd; Chuang, Jeffrey H

The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer

IL6/JAK/STAT3 信号轴是 SMARCB1 缺陷型膀胱癌的治疗弱点

Chandra Sekhar Amara, Karthik Reddy Kami Reddy #, Yang Yuntao #, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J H Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J Ellis, Andrea B Apolo, Leomar Y Ballester, Jianjun Gao, Donna E Hansel, Yair Lotan, H C