The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism
Dlk1-Gtl2基因座通过抑制PI3K-mTOR通路来限制线粒体代谢,从而维持长期造血干细胞的功能。
期刊:Cell Stem Cell
影响因子:20.4
doi:10.1016/j.stem.2015.11.001
Qian, Pengxu; He, Xi C; Paulson, Ariel; Li, Zhenrui; Tao, Fang; Perry, John M; Guo, Fengli; Zhao, Meng; Zhi, Lei; Venkatraman, Aparna; Haug, Jeffrey S; Parmely, Tari; Li, Hua; Dobrowsky, Rick T; Ding, Wen-Xing; Kono, Tomohiro; Ferguson-Smith, Anne C; Li, Linheng
发育与干细胞
mTOR
信号转导
代谢
线粒体
干细胞
细胞生物学