日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

α-突触核蛋白凝聚体中间原纤维的结构-毒性关系

Chen, Serene W; Barritt, Joseph D; Cascella, Roberta; Bigi, Alessandra; Cecchi, Cristina; Banchelli, Martina; Gallo, Angelo; Jarvis, James A; Chiti, Fabrizio; Dobson, Christopher M; Fusco, Giuliana; De Simone, Alfonso

The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

结构动力学在嗜热酶热适应中的作用

Fusco, Giuliana; Bemporad, Francesco; Chiti, Fabrizio; Dobson, Christopher M; De Simone, Alfonso

The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends

Hsc70解聚机制直接从α-突触核蛋白原纤维末端移除单体单元。

Schneider, Matthias M; Gautam, Saurabh; Herling, Therese W; Andrzejewska, Ewa; Krainer, Georg; Miller, Alyssa M; Trinkaus, Victoria A; Peter, Quentin A E; Ruggeri, Francesco Simone; Vendruscolo, Michele; Bracher, Andreas; Dobson, Christopher M; Hartl, F Ulrich; Knowles, Tuomas P J

Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems

利用人工毛细管系统中的剪切应力加速生物分子的反应速率

Hakala, Tuuli A; Yates, Emma V; Challa, Pavan K; Toprakcioglu, Zenon; Nadendla, Karthik; Matak-Vinkovic, Dijana; Dobson, Christopher M; Martínez, Rodrigo; Corzana, Francisco; Knowles, Tuomas P J; Bernardes, Gonçalo J L

The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces

小热休克蛋白αB-晶状体蛋白与α-突触核蛋白原纤维的结合是由熵力驱动的。

Scheidt, Tom; Carozza, Jacqueline A; Kolbe, Carl C; Aprile, Francesco A; Tkachenko, Olga; Bellaiche, Mathias M J; Meisl, Georg; Peter, Quentin A E; Herling, Therese W; Ness, Samuel; Castellana-Cruz, Marta; Benesch, Justin L P; Vendruscolo, Michele; Dobson, Christopher M; Arosio, Paolo; Knowles, Tuomas P J

Machine learning-aided protein identification from multidimensional signatures

基于多维特征的机器学习辅助蛋白质鉴定

Zhang, Yuewen; Wright, Maya A; Saar, Kadi L; Challa, Pavankumar; Morgunov, Alexey S; Peter, Quentin A E; Devenish, Sean; Dobson, Christopher M; Knowles, Tuomas P J

Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response

出版商更正:两种人类代谢物通过胞质未折叠蛋白反应挽救秀丽隐杆线虫阿尔茨海默病模型

Joshi, Priyanka; Perni, Michele; Limbocker, Ryan; Mannini, Benedetta; Casford, Sam; Chia, Sean; Habchi, Johnny; Labbadia, Johnathan; Dobson, Christopher M; Vendruscolo, Michele

Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

出版商更正:多巴胺代谢物可稳定神经毒性β-淀粉样蛋白寡聚体

Cataldi, Rodrigo; Chia, Sean; Pisani, Katarina; Ruggeri, Francesco S; Xu, Catherine K; Šneideris, Tomas; Perni, Michele; Sarwat, Sunehera; Joshi, Priyanka; Kumita, Janet R; Linse, Sara; Habchi, Johnny; Knowles, Tuomas P J; Mannini, Benedetta; Dobson, Christopher M; Vendruscolo, Michele

Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease

利用A30P和A53T α-突触核蛋白秀丽隐杆线虫品系进行比较研究,以探究帕金森病的分子起源

Perni, Michele; van der Goot, Annemieke; Limbocker, Ryan; van Ham, Tjakko J; Aprile, Francesco A; Xu, Catherine K; Flagmeier, Patrick; Thijssen, Karen; Sormanni, Pietro; Fusco, Giuliana; Chen, Serene W; Challa, Pavan K; Kirkegaard, Julius B; Laine, Romain F; Ma, Kai Yu; Müller, Martin B D; Sinnige, Tessa; Kumita, Janet R; Cohen, Samuel I A; Seinstra, Renée; Kaminski Schierle, Gabriele S; Kaminski, Clemens F; Barbut, Denise; De Simone, Alfonso; Knowles, Tuomas P J; Zasloff, Michael; Nollen, Ellen A A; Vendruscolo, Michele; Dobson, Christopher M

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

鲨胺及其衍生物调节β-淀粉样蛋白和α-突触核蛋白的聚集,并抑制其寡聚体的毒性

Limbocker, Ryan; Staats, Roxine; Chia, Sean; Ruggeri, Francesco S; Mannini, Benedetta; Xu, Catherine K; Perni, Michele; Cascella, Roberta; Bigi, Alessandra; Sasser, Liam R; Block, Natalie R; Wright, Aidan K; Kreiser, Ryan P; Custy, Edward T; Meisl, Georg; Errico, Silvia; Habchi, Johnny; Flagmeier, Patrick; Kartanas, Tadas; Hollows, Jared E; Nguyen, Lam T; LeForte, Kathleen; Barbut, Denise; Kumita, Janet R; Cecchi, Cristina; Zasloff, Michael; Knowles, Tuomas P J; Dobson, Christopher M; Chiti, Fabrizio; Vendruscolo, Michele