日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FLT201, a novel liver-directed AAV gene therapy candidate for Gaucher disease type 1.

FLT201 是一种新型的肝脏靶向 AAV 基因治疗候选药物,用于治疗 1 型戈谢病。

Comper Fabrizio, Miranda Carlos J, Liou Benjamin, Dodev Tihomir, Jeyakumar Jey M, Canavese Miriam, Cocita Clement, Khoshrou Khashayar, Tiscornia Gustavo, Chisari Elisa, Stotter Emmaline, Shehu Erald, Sridharan Sudharsan, Yu I-Mei, Pandya Jalpa, Khinder Jaminder, Northcott Natalie, Kalcheva Petya, Correia Samantha, Sun Ying, Dane Allison P, Sheridan Rose, Nathwani Amit C, Corbau Romuald

Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

靶向黑色素瘤相关抗原硫酸软骨素蛋白聚糖4的IgE抗体的抗癌促炎作用

Chauhan, Jitesh; Grandits, Melanie; Palhares, Lais C G F; Mele, Silvia; Nakamura, Mano; López-Abente, Jacobo; Crescioli, Silvia; Laddach, Roman; Romero-Clavijo, Pablo; Cheung, Anthony; Stavraka, Chara; Chenoweth, Alicia M; Sow, Heng Sheng; Chiaruttini, Giulia; Gilbert, Amy E; Dodev, Tihomir; Koers, Alexander; Pellizzari, Giulia; Ilieva, Kristina M; Man, Francis; Ali, Niwa; Hobbs, Carl; Lombardi, Sara; Lionarons, Daniël A; Gould, Hannah J; Beavil, Andrew J; Geh, Jenny L C; MacKenzie Ross, Alastair D; Healy, Ciaran; Calonje, Eduardo; Downward, Julian; Nestle, Frank O; Tsoka, Sophia; Josephs, Debra H; Blower, Philip J; Karagiannis, Panagiotis; Lacy, Katie E; Spicer, James; Karagiannis, Sophia N; Bax, Heather J

In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart.

肿瘤靶向 IgE 抗体的体内转运:分子成像显示其肝胆清除速度比 IgG 抗体更快

Man Francis, Koers Alexander, Karagiannis Panagiotis, Josephs Debra H, Bax Heather J, Gilbert Amy E, Dodev Tihomir S, Mele Silvia, Chiarruttini Giulia, Crescioli Silvia, Chauhan Jitesh, Blower Julia E, Cooper Margaret S, Spicer James, Karagiannis Sophia N, Blower Philip J

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE

一种具有免疫学意义的啮齿动物模型证实了使用肿瘤特异性IgE进行治疗的安全性。

Josephs, D H; Nakamura, M; Bax, H J; Dodev, T S; Muirhead, G; Saul, L; Karagiannis, P; Ilieva, K M; Crescioli, S; Gazinska, P; Woodman, N; Lombardelli, C; Kareemaghay, S; Selkirk, C; Lentfer, H; Barton, C; Canevari, S; Figini, M; Downes, N; Dombrowicz, D; Corrigan, C J; Nestle, F O; Jones, P S; Gould, H J; Blower, P J; Tsoka, S; Spicer, J F; Karagiannis, S N

Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition

患者衍生抗体与过敏原的复合物结构揭示了同时进行的常规和超抗原样识别

Alkistis N Mitropoulou, Holly Bowen, Tihomir S Dodev, Anna M Davies, Heather J Bax, Rebecca L Beavil, Andrew J Beavil, Hannah J Gould, Louisa K James, Brian J Sutton

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

抗叶酸受体α IgE(而非IgG)通过TNFα/MCP-1信号通路募集巨噬细胞攻击肿瘤

Josephs, Debra H; Bax, Heather J; Dodev, Tihomir; Georgouli, Mirella; Nakamura, Mano; Pellizzari, Giulia; Saul, Louise; Karagiannis, Panagiotis; Cheung, Anthony; Herraiz, Cecilia; Ilieva, Kristina M; Correa, Isabel; Fittall, Matthew; Crescioli, Silvia; Gazinska, Patrycja; Woodman, Natalie; Mele, Silvia; Chiaruttini, Giulia; Gilbert, Amy E; Koers, Alexander; Bracher, Marguerite; Selkirk, Christopher; Lentfer, Heike; Barton, Claire; Lever, Elliott; Muirhead, Gareth; Tsoka, Sophia; Canevari, Silvana; Figini, Mariangela; Montes, Ana; Downes, Noel; Dombrowicz, David; Corrigan, Christopher J; Beavil, Andrew J; Nestle, Frank O; Jones, Paul S; Gould, Hannah J; Sanz-Moreno, Victoria; Blower, Philip J; Spicer, James F; Karagiannis, Sophia N

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

功能活性 Fc 突变抗体可识别癌症抗原并快速高产量生成

Kristina M Ilieva, Judit Fazekas-Singer, Daniela Y Achkova, Tihomir S Dodev, Silvia Mele, Silvia Crescioli, Heather J Bax, Anthony Cheung, Panagiotis Karagiannis, Isabel Correa, Mariangela Figini, Rebecca Marlow, Debra H Josephs, Andrew J Beavil, John Maher, James F Spicer, Erika Jensen-Jarolim, And

IgE Trimers Drive SPE-7 Cytokinergic Activity

IgE 三聚体驱动 SPE-7 细胞因子活性

Heather J Bax, Holly Bowen, Rebecca L Beavil, Raymond Chung, Malcolm Ward, Anna M Davies, Tihomir S Dodev, James M McDonnell, Andrew J Beavil, Brian J Sutton, Hannah J Gould

Promiscuous antibodies characterised by their physico-chemical properties: From sequence to structure and back

以其物理化学性质为特征的混杂抗体:从序列到结构再到序列

Julie M J Laffy, Tihomir Dodev, Jamie A Macpherson, Catherine Townsend, Hui Chun Lu, Deborah Dunn-Walters, Franca Fraternali

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

相同特异性但不同类别的抗体抑制过敏原依赖性 IgE 活性

T S Dodev, H Bowen, M H Shamji, H J Bax, A J Beavil, J M McDonnell, S R Durham, B J Sutton, H J Gould, L K James