日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pooled CRISPR screen reveals genes critical for erythroblast enucleation

混合 CRISPR 筛选揭示了对成红细胞去核至关重要的基因

Tetard, Marilou; Lin, Tianjian; Peterson, Nana A; Gullberg, Rebekah C; Le Guen, Yann; Doench, John G; Egan, Elizabeth S

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

利用细胞周期蛋白A/B RxL抑制剂靶向G1-S检查点受损的癌症

Shilpa Singh ,Catherine E Gleason ,Min Fang ,Yasmin N Laimon ,Vishal Khivansara ,Shanhai Xie ,Yavuz T Durmaz ,Aniruddha Sarkar ,Kenneth Ngo ,Varunika Savla ,Yixiang Li ,Muhannad Abu-Remaileh ,Xinyue Li ,Marie-Anais Locquet ,Bishma Tuladhar ,Ranya Odeh ,Frances Hamkins-Indik ,Daphne He ,Miles W Membreno ,Meisam Nosrati ,Nathan N Gushwa ,Siegfried S F Leung ,Breena Fraga-Walton ,Luis Hernandez ,Miguel P Baldomero ,Bryan M Lent ,David Spellmeyer ,Joshua F Luna ,Dalena Hoang ,Yuliana Gritsenko ,Manesh Chand ,Megan K DeMart ,Sammy Metobo ,Chinmay Bhatt ,Justin A Shapiro ,Kai Yang ,Nathan J Dupper ,Andrew T Bockus ,Jinshu Fang ,Ramesh Bambal ,Peadar Cremin ,John G Doench ,James B Aggen ,Li-Fen Liu ,Bernard Levin ,Evelyn W Wang ,Iolanda Vendrell ,Roman Fischer ,Benedikt Kessler ,Prafulla C Gokhale ,Sabina Signoretti ,Alexander Spektor ,Constantine Kreatsoulas ,Marie Evangelista ,Rajinder Singh ,David J Earp ,Deepak Nijhawan ,Pablo D Garcia ,Matthew G Oser

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma.

体内 CRISPR 筛选可识别骨髓瘤中 CAR T 细胞功能的调节因子。

Knudsen Nelson H, Escobar Giulia, Korell Felix, Kienka Tamina, Nobrega Celeste, Anderson Seth, Cheng Andrew Y, Zschummel Maria, Armstrong Alexander, Bouffard Amanda, Kann Michael C, Goncalves Sadie, Pope Hans W, Pezeshki Mitra, Rojas Alexander, Suermondt Juliette S M T, Phillips Merle, Berger Trisha R, Park Sangwoo, Salas-Benito Diego, Darnell Elijah P, Birocchi Filippo, Leick Mark B, Larson Rebecca C, Doench John G, Sen Debattama, Yates Kathleen B, Manguso Robert T, Maus Marcela V

Morphological map of under- and overexpression of genes in human cells

人类细胞中基因表达不足和过表达的形态学图谱

Chandrasekaran, Srinivas Niranj; Alix, Eric; Arevalo, John; Borowa, Adriana; Byrne, Patrick J; Charles, William G; Chen, Zitong S; Cimini, Beth A; Deng, Boxiong; Doench, John G; Ewald, Jessica D; Fritchman, Briana; Fuller, Colin J; Gaetz, Jedidiah; Goodale, Amy; Haghighi, Marzieh; Han, Yu; Hanifehlou, Zahra; Hennig, Holger; Hernandez, Desiree; Jacob, Christina B; James, Tim; Jetka, Tomasz; Kalinin, Alexandr A; Komalo, Ben; Kost-Alimova, Maria; Krawiec, Tomasz; Marion, Brittany A; Martin, Glynn; McCarthy, Nicola Jane; Miller, Lisa; Monsees, Arne; Moshkov, Nikita; Muñoz, Alán F; Ogier, Arnaud; Otrocka, Magdalena; Rataj, Krzysztof; Root, David E; Rubbo, Francesco; Scrace, Simon; Selinger, Douglas W; Senft, Rebecca A; Sommer, Peter; Thibaudeau, Amandine; Trisorus, Sarah; Valiya Veettil, Rahul; Van Trump, William J; Wang, Sui; Warchoł, Michał; Weisbart, Erin; Weiss, Amélie; Wiest, Michael; Zaremba, Agata; Zinovyev, Andrei; Singh, Shantanu; Carpenter, Anne E

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex

将临床阶段化合物的抗肿瘤作用机制定义为核孔复合物的选择性降解剂。

Linjie Yuan,Wenzhi Ji,Brendan G Dwyer,Joey Lu,Jing Bian,Gianna M Colombo,Michael J Martinez,Daniel Fernandez,Nick A Phillips,Michelle T Tang,Christine Wenjie Zhou,Nirk E Quispe Calla,Cesar Guzman Huancas,Michael Eckart,Jessica Tran,Hannah M Jones,Tian Qiu,John G Doench,Matthew G Rees,Jennifer A Roth,Michael D Cameron,Gregory W Charville,Calvin J Kuo,Scott J Dixon,Tinghu Zhang,Stephen M Hinshaw,Nathanael S Gray,Steven M Corsello

Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer

细胞周期蛋白D1的需求是肾癌中细胞自主性HIF2依赖性的基础

Nitin H Shirole ,Devishi Kesar ,Yenarae Lee ,Amy Goodale ,Sudeepa Syamala ,Shweta Kukreja ,Rong Li ,Xintao Qiu ,Wenyu Yu ,Seth Goldman ,Paloma Cejas ,Henry W Long ,Karen Adelman ,John G Doench ,William R Sellers ,William G Kaelin Jr

A STUB1-CHIC2 complex inhibits CD8(+) T cells to restrain tumor immunity

STUB1-CHIC2复合物抑制CD8(+) T细胞,从而抑制肿瘤免疫

LaFleur, Martin W; Milling, Lauren E; Prathima, Priyamvada; Li, Vivian; Lemmen, Ashlyn M; Streeter, Ivy S L; Heisig, Paul K S; Derosia, Nicole M; Riffo, Elizabeth; Xu, Haonan; Nguyen, Thao H; Kolengaden, Aashiya; Markson, Samuel C; Doench, John G; Sharpe, Arlene H

ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes

内质网蛋白CLCC1促进疱疹病毒和宿主细胞核膜融合。

Dai, Bing; Sperl, Adrian W; Polack, Lucas; Mejia, Isabel; Dame, Haley; Huynh, Tien; Deveney, Chloe; Lavoie, Nathalie; Lee, Chanyoung; Doench, John G; Daugherty, Matthew D; Heldwein, Ekaterina E

HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors.

HKU5 蝙蝠梅尔贝病毒以蝙蝠和水貂的 ACE2 作为入侵受体

Madel Alfajaro Mia, Keeler Emma L, Li Ning, Catanzaro Nicholas J, Teng I-Ting, Zhao Zhe, Grunst Michael W, Yount Boyd, Schäfer Alexandra, Wang Danyi, Kim Arthur S, Synowiec Aleksandra, Peña-Hernández Mario A, Zepeda Samantha, Arinola Ridwan, Kaur Ramandeep, Menasche Bridget L, Wei Jin, Russell Gabriel A, Huck John, Song Jaewon, Ring Aaron, Iwasaki Akiko, Jangra Rohit K, Lee Sanghyun, Martinez David R, Mothes Walther, Uchil Pradeep D, Doench John G, Spaulding Alicen B, Baric Ralph S, Serebryannyy Leonid, Tsybovsky Yaroslav, Zhou Tongqing, Douek Daniel C, Wilen Craig B

Multi-locus CRISPRi targeting with a single truncated guide RNA

利用单个截短的向导RNA进行多位点CRISPRi靶向

Molly M Moore # ,Siddarth Wekhande # ,Robbyn Issner ,Alejandro Collins ,Anna J Cruz ,Yanjing V Liu ,Nauman Javed ,Salvador Casaní-Galdón ,Jason D Buenrostro ,Charles B Epstein ,Eugenio Mattei ,John G Doench ,Bradley E Bernstein ,Noam Shoresh ,Fadi J Najm