日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

利用CD34+造血细胞进行慢病毒基因治疗A型血友病

Srivastava, Alok; Abraham, Aby; Aboobacker, Fouzia; Singh, Gurbind; Geevar, Tulasi; Kulkarni, Uday; Selvarajan, Sushil; Korula, Anu; Dave, Rutvi Gautam; Shankar, Mohana; Singh, Abraham S; Jeba, Anbu; Kumaar, Navien; Benjamin, Christopher; Lakshmi, Kavitha M; Srivastava, Vivi Miriam; Shaji, Ramachandran V; Nair, Sukesh C; Brown, Harrison C; Denning, Gabriela; Lollar, Pete; Doering, Christopher B; Spencer, Trent

Transplanted gene-modified placental cells boost FVIII activity in pediatric sheep without eliciting immunity, toxicity, or adverse events.

移植基因修饰的胎盘细胞可提高幼羊体内的 FVIII 活性,而不会引起免疫反应、毒性或不良反应。

Trevisan Brady, Rodriguez Martin, Ramamurthy Ritu, George Sunil, Babatunde Oluwaseun O, Dizon Jacqueline, Shields Jordan, Lankford Shannon, Schwahn Denise, Gautreaux Michael, Farland Andrew, Owen John, Atala Anthony, Doering Christopher B, Spencer H Trent, Porada Christopher D, Almeida-Porada Graça

Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction

通过祖先序列重建鉴定的增强型凝血因子IX变体的人源化和功能表征

Coyle, Christopher W; Knight, Kristopher A; Brown, Harrison C; George, Stephan N; Denning, Gabriela; Branella, Gianna M; Childers, Kenneth C; Spiegel, P Clint; Spencer, H Trent; Doering, Christopher B

Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain

凝血因子VIII抑制的结构基础揭示了C1结构域上的一个共同抗原热点。

Childers, Kenneth C; Cowper, Ben; Vaughan, Jordan D; McGill, Juliet R; Davulcu, Omar; Lollar, Pete; Doering, Christopher B; Coxon, Carmen H; Spiegel, Paul C Jr

Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor

凝血因子VIII与患者来源的抗C1结构域抗体抑制剂结合的结构

Childers, Kenneth C; Avery, Nathan G; Estrada Alamo, Kevin A; Davulcu, Omar; Haynes, Rose Marie; Lollar, Pete; Doering, Christopher B; Coxon, Carmen H; Spiegel, P Clint

Nonhuman glycans can regulate anti-factor VIII antibody formation in mice

非人源聚糖可以调节小鼠体内抗VIII因子抗体的形成。

Arthur, Connie M; Zerra, Patricia E; Shin, Sooncheon; Wang, Jianmei; Song, Xeuzheng; Doering, Christopher B; Lollar, Pete; Meeks, Shannon; Stowell, Sean R

Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice

药代动力学分析确定了AAV基因治疗后A型血友病小鼠的VIII因子免疫原性阈值。

Lundgren, Taran S; Denning, Gabriela; Stowell, Sean R; Spencer, H Trent; Doering, Christopher B

Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials

解析体外γδ T细胞扩增的细胞成分,以优化神经母细胞瘤免疫治疗试验中有效细胞治疗供体的选择

Jonus, Hunter C; Burnham, Rebecca E; Ho, Andrew; Pilgrim, Adeiye A; Shim, Jenny; Doering, Christopher B; Spencer, H Trent; Goldsmith, Kelly C

Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway

针对因子VIII的中和抗体可通过非生发中心途径产生

Patel, Seema R; Lundgren, Taran S; Baldwin, Wallace Hunter; Cox, Courtney; Parker, Ernest T; Healey, John F; Jajosky, Ryan P; Zerra, Patricia E; Josephson, Cassandra D; Doering, Christopher B; Stowell, Sean R; Meeks, Shannon L

Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor

血液凝固因子VIII与抗C1结构域致病性抗体抑制剂复合物的结构

Gish, Joseph S; Jarvis, Lexi; Childers, Kenneth C; Peters, Shaun C; Garrels, Connor S; Smith, Ian W; Spencer, H Trent; Doering, Christopher B; Lollar, Pete; Spiegel, P Clint