日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target

天然产物介导的反应劫持机制证实了疟原虫天冬氨酰tRNA合成酶作为抗疟药物靶点的有效性

Ketprasit, Nutpakal; Tai, Chia-Wei; Sharma, Vivek Kumar; Manickam, Yogavel; Khandokar, Yogesh; Ye, Xi; Dogovski, Con; Hilko, David H; Morton, Craig J; Braun, Anne-Sophie C; Leeming, Michael G; Siddharam, Bagale; Shami, Gerald J; Pradeepkumar, Pushpangadan Indira; Panjikar, Santosh; Poulsen, Sally-Ann; Griffin, Michael D W; Sharma, Amit; Tilley, Leann; Xie, Stanley C

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

一种强效且选择性的恶性疟原虫酪氨酸 tRNA 合成酶反应劫持抑制剂在体内表现出单剂量口服疗效

Xie Stanley C, Tai Chia-Wei, Morton Craig J, Ma Liting, Huang Shih-Chung, Wittlin Sergio, Du Yawei, Hu Yongbo, Dogovski Con, Salimimarand Mina, Griffin Robert, England Dylan, de la Cruz Elisa, Deni Ioanna, Yeo Tomas, Burkhard Anna Y, Striepen Josefine, Schindler Kyra A, Crespo Benigno, Gamo Francisco J, Khandokar Yogesh, Hutton Craig A, Rabie Tayla, Birkholtz Lyn-Marié, Famodimu Mufuliat T, Delves Michael J, Bolsher Judith, Koolen Karin M J, van der Laak Rianne, Aguiar Anna C C, Pereira Dhelio B, Guido Rafael V C, Creek Darren J, Fidock David A, Dick Lawrence R, Brand Stephen L, Gould Alexandra E, Langston Steven, Griffin Michael D W, Tilley Leann

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

恶性疟原虫天冬酰胺tRNA合成酶的反应劫持抑制

Xie, Stanley C; Wang, Yinuo; Morton, Craig J; Metcalfe, Riley D; Dogovski, Con; Pasaje, Charisse Flerida A; Dunn, Elyse; Luth, Madeline R; Kumpornsin, Krittikorn; Istvan, Eva S; Park, Joon Sung; Fairhurst, Kate J; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N; Klug, Dana M; Rutledge, Peter J; Godoy, Luiz C; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P; Maity, Bikash C; Thomson, Patrick; Foley, Thomas; Tan, Derek S; Niles, Jacquin C; Han, Byung Woo; Goldberg, Daniel E; Burrows, Jeremy; Fidock, David A; Lee, Marcus C S; Winzeler, Elizabeth A; Griffin, Michael D W; Todd, Matthew H; Tilley, Leann

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

设计对恶性疟原虫具有体内口服疗效且对人蛋白酶体具有选择性的蛋白酶体抑制剂

Xie, Stanley C; Metcalfe, Riley D; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J; Cohen, Lawrence H; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E; Barry, Daniel C; Liu, Boyin; Gillett, David L; Crespo-Fernandez, Benigno F; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C; Guido, Rafael V C; Baum, Jake; Hanson, Kirsten K; Winzeler, Elizabeth A; Gamo, Francisco-Javier; Fidock, David A; Baud, Delphine; Parker, Michael W; Brand, Stephen; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum

动态应激模型解释了青蒿素治疗恶性疟原虫的延迟药物效应

Cao, Pengxing; Klonis, Nectarios; Zaloumis, Sophie; Dogovski, Con; Xie, Stanley C; Saralamba, Sompob; White, Lisa J; Fowkes, Freya J I; Tilley, Leann; Simpson, Julie A; McCaw, James M

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

血红蛋白降解是早期环状疟原虫对青蒿素敏感的根本原因。

Xie, Stanley C; Dogovski, Con; Hanssen, Eric; Chiu, Francis; Yang, Tuo; Crespo, Maria P; Stafford, Che; Batinovic, Steven; Teguh, Silvia; Charman, Susan; Klonis, Nectarios; Tilley, Leann

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

靶向恶性疟原虫的细胞应激反应以克服青蒿素耐药性

Dogovski, Con; Xie, Stanley C; Burgio, Gaetan; Bridgford, Jess; Mok, Sachel; McCaw, James M; Chotivanich, Kesinee; Kenny, Shannon; Gnädig, Nina; Straimer, Judith; Bozdech, Zbynek; Fidock, David A; Simpson, Julie A; Dondorp, Arjen M; Foote, Simon; Klonis, Nectarios; Tilley, Leann

Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein

通过化学方法抑制AraC样转录激活蛋白的DNA结合域,从而削弱细菌毒力。

Yang, Ji; Hocking, Dianna M; Cheng, Catherine; Dogovski, Con; Perugini, Matthew A; Holien, Jessica K; Parker, Michael W; Hartland, Elizabeth L; Tauschek, Marija; Robins-Browne, Roy M

Cloning to crystallization of dihydrodipicolinate synthase from the intracellular pathogen Legionella pneumophila

从胞内病原体嗜肺军团菌中克隆并结晶二氢吡啶二羧酸合成酶

Siddiqui, Tanzeela; Paxman, Jason J; Dogovski, Con; Panjikar, Santosh; Perugini, Matthew A

Dimerization of plant defensin NaD1 enhances its antifungal activity

植物防御素NaD1的二聚化增强了其抗真菌活性

Lay, Fung T; Mills, Grant D; Poon, Ivan K H; Cowieson, Nathan P; Kirby, Nigel; Baxter, Amy A; van der Weerden, Nicole L; Dogovski, Con; Perugini, Matthew A; Anderson, Marilyn A; Kvansakul, Marc; Hulett, Mark D