日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触。

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Cedeño Kwong Claudia, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids.

MEF2C自闭症患者hiPSC神经元和脑类器官中miRNA表达和兴奋失调

Trudler Dorit, Ghatak Swagata, Bula Michael, Parker James, Talantova Maria, Luevanos Melissa, Labra Sergio, Grabauskas Titas, Noveral Sarah Moore, Teranaka Mayu, Schahrer Emily, Dolatabadi Nima, Bakker Clare, Lopez Kevin, Sultan Abdullah, Patel Parth, Chan Agnes, Choi Yongwook, Kawaguchi Riki, Stankiewicz Pawel, Garcia-Bassets Ivan, Kozbial Piotr, Rosenfeld Michael G, Nakanishi Nobuki, Geschwind Daniel H, Chan Shing Fai, Lin Wei, Schork Nicholas J, Ambasudhan Rajesh, Lipton Stuart A

S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity

阿尔茨海默病中CRTC1的S-亚硝基化会损害神经元活动诱导的CREB依赖性基因表达。

Zhang, Xu; Vlkolinsky, Roman; Wu, Chongyang; Dolatabadi, Nima; Scott, Henry; Prikhodko, Olga; Zhang, Andrew; Blanco, Mayra; Lang, Nhi; Piña-Crespo, Juan; Nakamura, Tomohiro; Roberto, Marisa; Lipton, Stuart A

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Kwong Claudia Cedeño, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

可溶性α-突触核蛋白-抗体复合物激活hiPSC衍生小胶质细胞中的NLRP3炎症小体

Trudler, Dorit; Nazor, Kristopher L; Eisele, Yvonne S; Grabauskas, Titas; Dolatabadi, Nima; Parker, James; Sultan, Abdullah; Zhong, Zhenyu; Goodwin, Marshall S; Levites, Yona; Golde, Todd E; Kelly, Jeffery W; Sierks, Michael R; Schork, Nicholas J; Karin, Michael; Ambasudhan, Rajesh; Lipton, Stuart A

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models

PINK1的S-亚硝基化减弱了基于hiPSC的帕金森病模型中PINK1/Parkin依赖的线粒体自噬

Oh, Chang-Ki; Sultan, Abdullah; Platzer, Joseph; Dolatabadi, Nima; Soldner, Frank; McClatchy, Daniel B; Diedrich, Jolene K; Yates, John R 3rd; Ambasudhan, Rajesh; Nakamura, Tomohiro; Jaenisch, Rudolf; Lipton, Stuart A

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

高血糖和寡聚β-淀粉样蛋白通过异常蛋白S-亚硝基化的共同途径破坏突触。

Akhtar, Mohd Waseem; Sanz-Blasco, Sara; Dolatabadi, Nima; Parker, James; Chon, Kevin; Lee, Michelle S; Soussou, Walid; McKercher, Scott R; Ambasudhan, Rajesh; Nakamura, Tomohiro; Lipton, Stuart A

Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells

利用基因编程的人类胚胎干细胞衍生的神经祖细胞进行帕金森病细胞治疗的潜力

Ambasudhan, Rajesh; Dolatabadi, Nima; Nutter, Anthony; Masliah, Eliezer; Mckercher, Scott R; Lipton, Stuart A

Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish

Orai1 缺陷会导致斑马鱼出现心力衰竭和骨骼肌病。

Völkers, Mirko; Dolatabadi, Nima; Gude, Natalie; Most, Patrick; Sussman, Mark A; Hassel, David

Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes

Orai1和Stim1调节心肌细胞的正常生长和肥大生长

Voelkers, Mirko; Salz, Mareen; Herzog, Nicole; Frank, Derk; Dolatabadi, Nima; Frey, Norbert; Gude, Natalie; Friedrich, Oliver; Koch, Walter J; Katus, Hugo A; Sussman, Mark A; Most, Patrick