日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.

致病性 Tau 突变导致自噬溶酶体功能障碍,从而限制额颞叶痴呆模型中 Tau 的降解。

Mirfakhar Farzaneh S, Marsh Jacob A, Sato Chihiro, Schache Kylie J, Minaya Miguel A, Dolle Roland E, Pak Stephen C, Silverman Gary A, Perlmutter David H, Macauley Shannon L, Karch Celeste M

Selective inhibition of ERO1α with M6766, a novel small-molecule inhibitor, prevents arterial thrombosis and ischemic stroke in mice.

使用新型小分子抑制剂 M6766 选择性抑制 ERO1α,可预防小鼠动脉血栓形成和缺血性中风

Wang Jinzhi, Kim Jae-Sung, Jha Vishwanath, Brown Gavriel, Lee Jingu, Bokorova Radka, Jin Bo-Ram, Ahmed Muteen, Castelblanco Esmeralda, Johnson Daniel, Prinsen Michael, Ilagan Ma Xenia G, Remedi Maria S, Razani Babak, Dolle Roland E, Cho Jaehyung

Targeting hepatocyte-specific SLC2A8 blocks hepatic steatosis and dissociates TCA cycle flux inhibition from glutamine anaplerosis

靶向肝细胞特异性SLC2A8可阻断肝脂肪变性,并将三羧酸循环通量抑制与谷氨酰胺补充代谢分离。

Adams, Joshua A; Zhang, Yiming; Sun, Jiameng; Tilston-Lunel, Andrew; Higgins, Cassandra B; Heitmeier, Monique; Ballentine, Sam; Tycksen, Eric; Dolle, Roland E; Hruz, Paul W; DeBosch, Brian J

Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism.

乙胺嘧啶及其强效类似物通过抑制一碳代谢来抑制 NRF2。

Chembo Julius, Bowman Brittany M, Lapak Kyle, Wilkerson Emily, Wamsley Nathan T, Paiboonrungruang Chorlada, Cho Kevin, Medcalf Matthew R, Wang Haining, Patti Gary J, Dolle Roland E, Chen Xiaoxin, Zolkind Paul, Major Michael B

Sequelae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

通过自噬增强重编程人类神经元中线粒体动力学随年龄变化的后果和逆转

Klinman, Eva; Kwon, Ji-Sun; Dolle, Roland E; Pak, Stephen C; Silverman, Gary A; Perlmutter, David H; Yoo, Andrew S

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer

膳食果糖通过器官间脂质转移间接促进肿瘤生长。

Fowle-Grider, Ronald; Rowles, Joe L 3rd; Shen, Isabel; Wang, Yahui; Schwaiger-Haber, Michaela; Dunham, Alden J; Jayachandran, Kay; Inkman, Matthew; Zahner, Michael; Naser, Fuad J; Jackstadt, Madelyn M; Spalding, Jonathan L; Chiang, Sarah; McCommis, Kyle S; Dolle, Roland E; Kramer, Eva T; Zimmerman, Sarah M; Souroullas, George P; Finck, Brian N; Shriver, Leah P; Kaufman, Charles K; Schwarz, Julie K; Zhang, Jin; Patti, Gary J

Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

发现吲唑衍生物作为一类新型细菌DNA促旋酶B抑制剂

Zhang, Jing; Yang, Qingyi; Romero, Jan Antoinette C; Cross, Jason; Wang, Bin; Poutsiaka, Katherine M; Epie, Felix; Bevan, Douglas; Wu, Yuchuan; Moy, Terence; Daniel, Anu; Chamberlain, Brian; Carter, Nicole; Shotwell, Joseph; Arya, Anu; Kumar, Vipul; Silverman, Jared; Nguyen, Kien; Metcalf, Chester A 3rd; Ryan, Dominic; Lippa, Blaise; Dolle, Roland E

The discovery and development of the N-substituted trans-3,4-dimethyl-4-(3'-hydroxyphenyl)piperidine class of pure opioid receptor antagonists

N-取代的反式-3,4-二甲基-4-(3'-羟基苯基)哌啶类纯阿片受体拮抗剂的发现与开发

Carroll, F Ivy; Dolle, Roland E

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009

2009年药物发现和化学生物学化学库综合调查:

Dolle, Roland E; Bourdonnec, Bertrand Le; Worm, Karin; Morales, Guillermo A; Thomas, Craig J; Zhang, Wei