日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evolutionary transfer learning enables organism-wide inference of mammalian enhancer landscapes

进化迁移学习能够对哺乳动物增强子图谱进行全生物体范围的推断

Qiu, Chengxiang; Daza, Riza M; Welsh, Ian C; Patwardhan, Rupali P; Martin, Beth K; Li, Tony; Yang, Shizhao; Kempynck, Niklas; Taylor, Megan L; Fulton, Olivia; Le, Truc-Mai; O'Day, Diana R; Lalanne, Jean-Benoît; Domcke, Silvia; Murray, Stephen A; Aerts, Stein; Trapnell, Cole; Shendure, Jay

Lineage recording in monoclonal gastruloids reveals heritable modes of early development.

单克隆原肠胚谱系记录揭示了早期发育的可遗传模式

Regalado Samuel G, Qiu Chengxiang, Kottapalli Sanjay, Martin Beth K, Chen Wei, Liao Hanna, Kim Haedong, Li Xiaoyi, Lalanne Jean-Benoît, Hamazaki Nobuhiko, Domcke Silvia, Choi Junhong, Shendure Jay

Multiplex profiling of developmental cis-regulatory elements with quantitative single-cell expression reporters

利用定量单细胞表达报告基因对发育顺式调控元件进行多重分析

Jean-Benoît Lalanne #, Samuel G Regalado #, Silvia Domcke, Diego Calderon, Beth K Martin, Xiaoyi Li, Tony Li, Chase C Suiter, Choli Lee, Cole Trapnell, Jay Shendure

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements

多重单细胞 CRISPR 筛选,用于检测细胞类型特异性调控元件

Florence M Chardon # ,Troy A McDiarmid # ,Nicholas F Page ,Riza M Daza ,Beth K Martin ,Silvia Domcke ,Samuel G Regalado ,Jean-Benoît Lalanne ,Diego Calderon ,Xiaoyi Li ,Lea M Starita ,Stephan J Sanders ,Nadav Ahituv ,Jay Shendure

Noncoding variants are a rare cause of recessive developmental disorders in trans with coding variants

非编码变异是与编码变异同时导致隐性遗传发育障碍的罕见原因。

Lord, Jenny; Oquendo, Carolina J; Wai, Htoo A; Holloway, John G; Martin-Geary, Alexandra; Blakes, Alexander J M; Arciero, Elena; Domcke, Silvia; Childs, Anne-Marie; Low, Karen; Rankin, Julia; Baralle, Diana; Martin, Hilary C; Whiffin, Nicola

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements

多重单细胞 CRISPR 筛选,用于检测细胞类型特异性调控元件

Chardon, Florence M; McDiarmid, Troy A; Page, Nicholas F; Daza, Riza M; Martin, Beth; Domcke, Silvia; Regalado, Samuel G; Lalanne, Jean-Benoît; Calderon, Diego; Li, Xiaoyi; Starita, Lea M; Sanders, Stephan J; Ahituv, Nadav; Shendure, Jay

A time-resolved, multi-symbol molecular recorder via sequential genome editing

通过顺序基因组编辑实现时间分辨的多符号分子记录器

Junhong Choi, Wei Chen, Anna Minkina, Florence M Chardon, Chase C Suiter, Samuel G Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M Daza, Jay Shendure0

Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation

有证据表明,直接抑制转录因子结合是 DNA 甲基化抑制基因和重复的主要方式

Sebastian Kaluscha #, Silvia Domcke #, Christiane Wirbelauer, Michael B Stadler, Sevi Durdu, Lukas Burger, Dirk Schübeler

DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions

DNA 序列和染色质修饰因子共同作用,在印迹控制区域赋予表观遗传双稳态

Stefan Butz, Nina Schmolka, Ino D Karemaker, Rodrigo Villaseñor, Isabel Schwarz, Silvia Domcke, Esther C H Uijttewaal, Julian Jude, Florian Lienert, Arnaud R Krebs, Nathalie P de Wagenaar, Xue Bao, Johannes Zuber, Ulrich Elling, Dirk Schübeler, Tuncay Baubec

A human cell atlas of fetal chromatin accessibility

人类胎儿染色质可及性细胞图谱

Domcke, Silvia; Hill, Andrew J; Daza, Riza M; Cao, Junyue; O'Day, Diana R; Pliner, Hannah A; Aldinger, Kimberly A; Pokholok, Dmitry; Zhang, Fan; Milbank, Jennifer H; Zager, Michael A; Glass, Ian A; Steemers, Frank J; Doherty, Dan; Trapnell, Cole; Cusanovich, Darren A; Shendure, Jay