日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL

含有野生型和突变型 NOTCH3 的蛋白质聚集体是 CADASIL 动脉病理的主要驱动因素

Nicolas Dupré, Florian Gueniot, Valérie Domenga-Denier, Virginie Dubosclard, Christelle Nilles, David Hill-Eubanks, Christelle Morgenthaler-Roth, Mark T Nelson, Céline Keime, Lydia Danglot, Anne Joutel

Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

减少小动脉和毛细血管之间过渡段的肌肉过度增生可预防自发性脑出血

Ratelade, Julien; Klug, Nicholas R; Lombardi, Damiano; Angelim, Monara Kaelle Servulo Cruz; Dabertrand, Fabrice; Domenga-Denier, Valérie; Al-Shahi Salman, Rustam; Smith, Colin; Gerbeau, Jean-Frédéric; Nelson, Mark T; Joutel, Anne

Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL

血脑屏障渗漏并不是 CADASIL 白质病变的一致特征

Rikesh M Rajani, Julien Ratelade, Valérie Domenga-Denier, Yoshiki Hase, Hannu Kalimo, Raj N Kalaria, Anne Joutel

Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice

降低 Timp3 或玻连蛋白的表达可改善 CADASIL 小鼠的疾病症状。

Capone, Carmen; Cognat, Emmanuel; Ghezali, Lamia; Baron-Menguy, Céline; Aubin, Déborah; Mesnard, Laurent; Stöhr, Heidi; Domenga-Denier, Valérie; Nelson, Mark T; Joutel, Anne

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

对参与脑血流动力学调节的 TIMP3 敏感通路的机制洞察

Carmen Capone, Fabrice Dabertrand, Celine Baron-Menguy, Athena Chalaris, Lamia Ghezali, Valérie Domenga-Denier, Stefanie Schmidt, Clément Huneau, Stefan Rose-John, Mark T Nelson, Anne Joutel

Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model

CADASIL 的早期白质变化:临床前小鼠模型中节段性髓鞘内水肿的证据

Emmanuel Cognat, Sabine Cleophax, Valérie Domenga-Denier, Anne Joutel

Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL

过量 Notch3 ECD 导致细胞外基质蛋白异常募集:CADASIL 的新发病机制

Marie Monet-Leprêtre, Iman Haddad, Céline Baron-Menguy, Maï Fouillot-Panchal, Meriem Riani, Valérie Domenga-Denier, Claire Dussaule, Emmanuel Cognat, Joelle Vinh, Anne Joutel

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

Notch3靶基因的转录组分析表明,Grip2是脑血管肌源性反应的一种新型调节因子。

Fouillade, Charles; Baron-Menguy, Céline; Domenga-Denier, Valérie; Thibault, Christelle; Takamiya, Kogo; Huganir, Richard; Joutel, Anne

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

在脑缺血性小血管病的小鼠遗传模型中,脑血管功能障碍和微循环稀疏先于白质病变出现。

Joutel, Anne; Monet-Leprêtre, Marie; Gosele, Claudia; Baron-Menguy, Céline; Hammes, Annette; Schmidt, Sabine; Lemaire-Carrette, Barbara; Domenga, Valérie; Schedl, Andreas; Lacombe, Pierre; Hubner, Norbert

Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries

Notch3是脑部和尾部阻力动脉血管张力的主要调节因子。

Belin de Chantemèle, E J; Retailleau, K; Pinaud, F; Vessières, E; Bocquet, A; Guihot, A L; Lemaire, B; Domenga, V; Baufreton, C; Loufrani, L; Joutel, A; Henrion, D