Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice
使用单体 SARS-CoV-2 刺突抗原进行异源 DNA 引发/蛋白质加强免疫可使三聚体受体结合域结构冗余，从而在老年小鼠中诱导中和抗体
期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2023.1231274
Dominik Pflumm, Alina Seidel, Fabrice Klein, Rüdiger Groß, Lea Krutzke, Stefan Kochanek, Joris Kroschel, Jan Münch, Katja Stifter, Reinhold Schirmbeck
