日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism

斑马鱼运动神经元中人源TDP-43过表达可通过功能获得机制诱发类似运动神经元病(MND)的表型。

Hogan, Alison L; Kane, Madison; Chiu, Patrick; Richter, Grant; Maurel, Cindy; Wu, Sharlynn; Scherer, Natalie M; Don, Emily K; Lee, Albert; Blair, Ian P; Chung, Roger S; Morsch, Marco

Critical impact of lysine 136 in TDP-43 phase separation, compartmentalization, and aggregation in living vertebrates.

赖氨酸 136 对活脊椎动物中 TDP-43 相分离、区室化和聚集具有关键影响

Maurel Cindy, Scherer Natalie M, Luu Luan, Radford Rowan A, Hogan Alison, Merjane Jessica, Vidal-Itriago Andres, Don Emily K, Chapman Tyler, Cull Stephen, Vourc'h Patrick, Lisowski Leszek, Lee Albert, Chung Roger S, Morsch Marco

Microglia morphophysiological diversity and its implications for the CNS

小胶质细胞形态生理多样性及其对中枢神经系统的影响

Vidal-Itriago, Andrés; Radford, Rowan A W; Aramideh, Jason A; Maurel, Cindy; Scherer, Natalie M; Don, Emily K; Lee, Albert; Chung, Roger S; Graeber, Manuel B; Morsch, Marco

In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)

利用双分子荧光互补(BiFC)技术进行体内验证,以研究肌萎缩侧索硬化症(ALS)中的聚集体形成

Don, Emily K; Maschirow, Alina; Radford, Rowan A W; Scherer, Natalie M; Vidal-Itriago, Andrés; Hogan, Alison; Maurel, Cindy; Formella, Isabel; Stoddart, Jack J; Hall, Thomas E; Lee, Albert; Shi, Bingyang; Cole, Nicholas J; Laird, Angela S; Badrock, Andrew P; Chung, Roger S; Morsch, Marco

The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

蛋白质二硫键异构酶的氧化还原活性抑制细胞和斑马鱼模型中的肌萎缩侧索硬化症表型

Parakh, Sonam; Shadfar, Sina; Perri, Emma R; Ragagnin, Audrey M G; Piattoni, Claudia V; Fogolín, Mariela B; Yuan, Kristy C; Shahheydari, Hamideh; Don, Emily K; Thomas, Collen J; Hong, Yuning; Comini, Marcelo A; Laird, Angela S; Spencer, Damian M; Atkin, Julie D

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo

实时可视化体内单个脊髓运动神经元氧化应激介导的神经退行性变

Formella, Isabel; Svahn, Adam J; Radford, Rowan A W; Don, Emily K; Cole, Nicholas J; Hogan, Alison; Lee, Albert; Chung, Roger S; Morsch, Marco

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

实时研究TDP-43的核质转运:小胶质细胞功能受损导致TDP-43在退化运动神经元中轴突扩散

Svahn, Adam J; Don, Emily K; Badrock, Andrew P; Cole, Nicholas J; Graeber, Manuel B; Yerbury, Justin J; Chung, Roger; Morsch, Marco

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

利用传统紫外激光共聚焦显微镜诱导细胞应激和死亡

Morsch, Marco; Radford, Rowan A W; Don, Emily K; Lee, Albert; Hortle, Elinor; Cole, Nicholas J; Chung, Roger S

Genetic basis of hindlimb loss in a naturally occurring vertebrate model

自然发生的脊椎动物模型中后肢缺失的遗传基础

Don, Emily K; de Jong-Curtain, Tanya A; Doggett, Karen; Hall, Thomas E; Heng, Benjamin; Badrock, Andrew P; Winnick, Claire; Nicholson, Garth A; Guillemin, Gilles J; Currie, Peter D; Hesselson, Daniel; Heath, Joan K; Cole, Nicholas J

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord

斑马鱼脊髓中小胶质细胞吞噬死亡神经元的体内特征

Morsch, Marco; Radford, Rowan; Lee, Albert; Don, Emily K; Badrock, Andrew P; Hall, Thomas E; Cole, Nicholas J; Chung, Roger