Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8(+) T cell responses
4-1BB信号通路的慢性激活会诱导肿瘤引流淋巴结中肉芽肿的形成,这对后续的CD8(+) T细胞反应有害。
期刊:Cellular & Molecular Immunology
影响因子:19.8
doi:10.1038/s41423-020-00533-3
Kim, Seon-Hee; Singh, Rohit; Han, Chungyong; Cho, Eunjung; Kim, Yu I; Lee, Don G; Kim, Young H; Kim, Sang Soo; Shin, Dong Hoon; You, Hye Jin; Lee, Hyeon-Woo; Kwon, Byoung S; Choi, Beom K
肿瘤
T细胞
肿瘤免疫
炎症/感染
信号转导
CD8
T细胞
细胞生物学
免疫/内分泌