日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy

PROTAC 介导的 NR4A1 降解作为癌症免疫治疗的新策略

Lei Wang #, Yufeng Xiao #, Yuewan Luo, Rohan P Master, Jiao Mo, Myung-Chul Kim, Yi Liu, Chandra K Maharjan, Urvi M Patel, Umasankar De, Madison E Carelock, Tanzia Islam Tithi, Xiangming Li, Donald R Shaffer, Kevin R Guertin, Haoyang Zhuang, Emily Moser, Keiran S M Smalley, Dongwen Lv, Daohong Zhou, 

In vivo discovery of immunotherapy targets in the tumour microenvironment

在体内发现肿瘤微环境中的免疫治疗靶点

Penghui Zhou, Donald R Shaffer, Diana A Alvarez Arias, Yukoh Nakazaki, Wouter Pos, Alexis J Torres, Viviana Cremasco, Stephanie K Dougan, Glenn S Cowley, Kutlu Elpek, Jennifer Brogdon, John Lamb, Shannon J Turley, Hidde L Ploegh, David E Root, J Christopher Love, Glenn Dranoff, Nir Hacohen, Harvey C

Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma

嵌合受体工程化人类 T 细胞针对肿瘤基质的抗肿瘤作用

Sunitha Kakarla, Kevin K H Chow, Melinda Mata, Donald R Shaffer, Xiao-Tong Song, Meng-Fen Wu, Hao Liu, Lisa L Wang, David R Rowley, Klaus Pfizenmaier, Stephen Gottschalk

Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment

髓母细胞瘤细胞与内皮细胞之间的相互作用会触发强烈的趋化信号,将T淋巴细胞募集到肿瘤微环境中。

Vita S Salsman,Kevin K H Chow, Donald R Shaffer, Huseyin Kadikoy, Xiao-Nan Li, Claudia Gerken, Laszlo Perlaky, Leonid S Metelitsa, Xiuhua Gao, Meena Bhattacharjee, Karen Hirschi, Helen E Heslop, Stephen Gottschalk, Nabil Ahmed