日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Statin therapy inhibits fatty acid synthase via dynamic protein modifications

他汀类药物治疗通过动态蛋白质修饰抑制脂肪酸合酶

Alec G Trub, Gregory R Wagner, Kristin A Anderson, Scott B Crown, Guo-Fang Zhang, J Will Thompson, Olga R Ilkayeva, Robert D Stevens, Paul A Grimsrud, Rhushikesh A Kulkarni, Donald S Backos, Jordan L Meier, Matthew D Hirschey

Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

脱乙酰酶 SIRT5 对戊二酰辅酶 A 脱氢酶进行脱乙酰化,促进小鼠赖氨酸氧化

Dhaval P Bhatt, C Allie Mills, Kristin A Anderson, Bárbara J Henriques, Tânia G Lucas, Sara Francisco, Juan Liu, Olga R Ilkayeva, Alexander E Adams, Shreyas R Kulkarni, Donald S Backos, Michael B Major, Paul A Grimsrud, Cláudio M Gomes, Matthew D Hirschey

Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice

小鼠持续性、进行性肺纤维化和上皮重塑

Elizabeth F Redente, Bart P Black, Donald S Backos, Ali N Bahadur, Stephen M Humphries, David A Lynch, Rubin M Tuder, Rachel L Zemans, David W H Riches

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors

取代的氧吲哚-3-亚甲基作为AMP激活蛋白激酶(AMPK)抑制剂

Christopher J Matheson ,Kimberly A Casalvieri ,Donald S Backos ,Mohammed Minhajuddin ,Craig T Jordan ,Philip Reigan

Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy

开发单药细胞毒性有限的强效吡唑并嘧啶酮类 WEE1 抑制剂用于癌症治疗

Christopher J Matheson, Kimberly A Casalvieri, Donald S Backos, Philip Reigan

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

Nurr1 配体,1,1-双 (3'-吲哚基)-1-(对氯苯基)甲烷,调节神经胶质反应性,并在 MPTP 诱发的帕金森病中发挥神经保护作用

Sean L Hammond, Katriana A Popichak, Xi Li, Lindsay G Hunt, Evan H Richman, Pranav U Damale, Edwin K P Chong, Donald S Backos, Stephen Safe, Ronald B Tjalkens

Redox modulation of NQO1

NQO1的氧化还原调节

David Siegel, Donna D Dehn, Samantha S Bokatzian, Kevin Quinn, Donald S Backos, Andrea Di Francesco, Michel Bernier, Nichole Reisdorph, Rafael de Cabo, David Ross

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

补体蛋白与纳米颗粒蛋白冠结合并在体内进行动态交换

Fangfang Chen, Guankui Wang, James I Griffin, Barbara Brenneman, Nirmal K Banda, V Michael Holers, Donald S Backos, LinPing Wu, Seyed Moein Moghimi, Dmitri Simberg

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

SIRT4是一种赖氨酸脱酰酶,控制亮氨酸代谢和胰岛素分泌。

Kristin A Anderson ,Frank K Huynh ,Kelsey Fisher-Wellman ,J Darren Stuart ,Brett S Peterson ,Jonathan D Douros ,Gregory R Wagner ,J Will Thompson ,Andreas S Madsen ,Michelle F Green ,R Michael Sivley ,Olga R Ilkayeva ,Robert D Stevens ,Donald S Backos ,John A Capra ,Christian A Olsen ,Jonathan E Campbell ,Deborah M Muoio ,Paul A Grimsrud ,Matthew D Hirschey

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation

一类活性酰基辅酶A揭示了蛋白质酰化反应的非酶促起源

Gregory R Wagner ,Dhaval P Bhatt ,Thomas M O'Connell ,J Will Thompson ,Laura G Dubois ,Donald S Backos ,Hao Yang ,Grant A Mitchell ,Olga R Ilkayeva ,Robert D Stevens ,Paul A Grimsrud ,Matthew D Hirschey