日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

发现一种具有免疫治疗活性的首创共价变构SHP1抑制剂

Qu, Zihan; Meke, Frederick Nguele; Zhang, Zheng; Krabill, Aaron D; Muli, Christine S; Jassim, Brenson A; Dong, Jiajun; Nguyen, Quyen D; Bai, Yunpeng; Li, Jinyue; Miao, Yiming; Asadi, Bardia; Johnson, Levi M; Miao, Jinmin; Trader, Darci J; Tao, W Andy; Zhang, Zhong-Yin

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

蛋白质酪氨酸磷酸酶作为癌症免疫治疗的新兴靶点

Qu, Zihan; Dong, Jiajun; Zhang, Zhong-Yin

Room-temperature phosphorescence and anomalous piezochromism in molecular crystals enabled by iodine atomic orbital sharing

碘原子轨道共享使得分子晶体中出现室温磷光和异常压致变色现象

Xu, Tongge; Zhai, Chunguang; Liu, Ziyao; Yang, Xiaoying; Hu, Shuhe; Shang, Yuchen; Yue, Lei; Dong, Jiajun; Liu, Ran; Li, Quanjun; Yao, Mingguang; Liu, Bingbing

Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase

发现和评价活性位点导向的、高效、选择性磺基苯乙酸酰胺类拉福林磷酸酶抑制剂

Lin, Jianping; He, Rongjun; Qu, Zihan; Dong, Jiajun; Krabill, Aaron D; Wu, Li; Bai, Yunpeng; Conroy, Lindsey R; Bruntz, Ronald C; Miao, Yiming; Jassim, Brenson A; Babalola, Benjamin; Nguele Meke, Frederick Georges Bernard; Sun, Ramon; Gentry, Matthew S; Zhang, Zhong-Yin

Understanding the stability landscape of LbCas12a by deep analysis of stabilizing mutations and mutation combinations

通过对稳定突变和突变组合的深入分析,了解 LbCas12a 的稳定性图谱。

Dong, Jiajun; Wang, Shaojie; Xu, Wenxue; Xin, Jingyao; Liu, Jia

Deep Learning-Enhanced Spectroscopic Technologies for Food Quality Assessment: Convergence and Emerging Frontiers

深度学习增强光谱技术在食品质量评估中的应用:融合与新兴前沿

Lun, Zhichen; Wu, Xiaohong; Dong, Jiajun; Wu, Bin

Macrocyclic Peptides Containing an Imidazopyridinium (IP(+)) Unit Display Enhanced Passive Cell Permeability

含有咪唑并吡啶鎓 (IP(+)) 单元的大环肽表现出增强的被动细胞渗透性

Li, Bo; Parker, Joshua; Briggs, Skyler; Dong, Jiajun; Burke, James M; Kodadek, Thomas

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

产肠毒素脆弱拟杆菌分泌的 BFT-1 通过其功能性受体 NOD1 促进乳腺癌细胞干性和化学耐药性

Wei Ma, Lu Zhang, Weilong Chen, Zhaoxia Chang, Juchuanli Tu, Yuanyuan Qin, Yuwen Yao, Mengxue Dong, Jiajun Ding, Siqin Li, Fengkai Li, Qiaodan Deng, Yifei Yang, Tingting Feng, Fanrong Zhang, Xiying Shao, Xueyan He, Lixing Zhang, Guohong Hu, Quentin Liu, Yi-Zhou Jiang, Shu Zhu, Zhi Xiao, Dan Su, Tong

A general temperature-guided language model to design proteins of enhanced stability and activity

一种通用的温度引导语言模型,用于设计具有增强稳定性和活性的蛋白质

Jiang, Fan; Li, Mingchen; Dong, Jiajun; Yu, Yuanxi; Sun, Xinyu; Wu, Banghao; Huang, Jin; Kang, Liqi; Pei, Yufeng; Zhang, Liang; Wang, Shaojie; Xu, Wenxue; Xin, Jingyao; Ouyang, Wanli; Fan, Guisheng; Zheng, Lirong; Tan, Yang; Hu, Zhiqiang; Xiong, Yi; Feng, Yan; Yang, Guangyu; Liu, Qian; Song, Jie; Liu, Jia; Hong, Liang; Tan, Pan

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.

开发新型含膦二氟甲基的磷酸酪氨酸模拟物,以及首创的高效、选择性和生物利用度高的CDC14磷酸酶抑制剂

Dong Jiajun, Jassim Brenson A, Milholland Kedric L, Qu Zihan, Bai Yunpeng, Miao Yiming, Miao Jinmin, Ma Yuan, Lin Jianping, Hall Mark C, Zhang Zhong-Yin