Donow相关文献与解析，生知库 | 链接生命科学的每一步

Martin D Burkhalter ,Tom Stiff ,Lars D Maerz ,Teresa Casar Tena ,Heike Wiese ,Julian Gerhards ,Steffen A Sailer ,Linh Anna Trúc Vu ,Max Duong Phu ,Cornelia Donow ,Marius Alupei ,Sebastian Iben ,Marco Groth ,Sebastian Wiese ,Joseph A Church ,Penelope A Jeggo ,Melanie Philipp

发表日期：2024

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Advanced Spray-Dried Inhalable Microparticles/Nanoparticles of an Innovative Mitophagy Activator for Targeted Lung Delivery: Design, Comprehensive Characterization, Human Lung Cell Culture, and In Vitro Aerosol Dispersion Performance

一种创新型线粒体自噬激活剂的先进喷雾干燥可吸入微粒/纳米颗粒靶向肺部递送：设计、全面表征、人肺细胞培养和体外气溶胶分散性能

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.4c00436

Shafi, Hasham; Lora, Andrea J; Donow, Haley M; Aggarwal, Saurabh; Fu, Panfeng; Wang, Ting; Mansour, Heidi M

Structure-Activity Relationship of Pyrrolidine Pentamine Derivatives as Inhibitors of the Aminoglycoside 6'- N-Acetyltransferase Type Ib

吡咯烷五胺衍生物作为氨基糖苷类 6'-N-乙酰转移酶 Ib 型抑制剂的构效关系

期刊:Antibiotics-Basel

影响因子:

doi:10.3390/antibiotics13070672

Jan Sklenicka, Tung Tran, Maria S Ramirez, Haley M Donow, Angel J Magaña, Travis LaVoi, Yasir Mamun, Verónica Jimenez, Prem Chapagain, Radleigh Santos, Clemencia Pinilla, Marc A Giulianotti, Marcelo E Tolmasky

发表日期：2024

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Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development

蛋白偶联受体激酶 4 在纤毛和肾脏发育过程中抑制 mTOR 信号传导不需要激酶活性

期刊:Journal of the American Society of Nephrology

影响因子:10.3

doi:10.1681/ASN.0000000000000082

Julian Gerhards, Lars D Maerz, Edda S F Matthees, Cornelia Donow, Barbara Moepps, Richard T Premont, Martin D Burkhalter, Carsten Hoffmann, Melanie Philipp

The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

三种化合物的平行构效关系筛选鉴定出吡咯烷双环胍类黑皮质素-3受体（MC3R）小分子配体的共同激动剂药效团

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms241210145

Mark D Ericson, Katie T Freeman, Travis M LaVoi, Haley M Donow, Radleigh G Santos, Marc A Giulianotti, Clemencia Pinilla, Richard A Houghten, Carrie Haskell-Luevano

信号转导

发表日期：2023

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Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity

鉴定出可释放出传染性降低的减毒病毒的 SARS-CoV-2 刺突棕榈酰化抑制剂

期刊:Viruses-Basel

影响因子:3.8

doi:10.3390/v14030531

Ahmed A Ramadan, Karthick Mayilsamy, Andrew R McGill, Anandita Ghosh, Marc A Giulianotti, Haley M Donow, Shyam S Mohapatra, Subhra Mohapatra, Bala Chandran, Robert J Deschenes, Arunava Roy

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

基于功能混合物的定位扫描可识别出具有纳摩尔级黑皮质素-4 受体效力并与内源性 AGRP(86-132) 拮抗剂等效效力的拮抗剂四肽序列 (LAtTeS) 库

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.1c01417

Mark D Ericson, Skye R Doering, Courtney M Larson, Katie T Freeman, Travis M LaVoi, Haley M Donow, Radleigh G Santos, Rachel H Cho, Zoe M Koerperich, Marc A Giulianotti, Clemencia Pinilla, Richard A Houghten, Carrie Haskell-Luevano

Inhibition of Aminoglycoside 6'- N-acetyltransferase Type Ib (AAC(6')-Ib): Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors

氨基糖苷类 6'- N-乙酰转移酶 Ib 型 (AAC(6')-Ib) 的抑制：取代吡咯烷五胺衍生物作为抑制剂的构效关系

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines9091218

Kenneth Rocha, Jesus Magallon, Craig Reeves, Kimberly Phan, Peter Vu, Crista L Oakley-Havens, Stella Kwan, Maria Soledad Ramirez, Travis LaVoi, Haley Donow, Prem Chapagain, Radleigh Santos, Clemencia Pinilla, Marc A Giulianotti, Marcelo E Tolmasky

发表日期：2021

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Nucleolar Stress Functions Upstream to Stimulate Expression of Autophagy Regulators

核仁应激作用于上游，刺激自噬调节剂的表达

期刊:Cancers

影响因子:

doi:10.3390/cancers13246220

David P Dannheisig, Anna Schimansky, Cornelia Donow, Astrid S Pfister

Resting cells rely on the DNA helicase component MCM2 to build cilia

静止细胞依靠DNA解旋酶组分MCM2来构建纤毛。

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gky945

Teresa Casar Tena ，Lars D Maerz ，Karol Szafranski ，Marco Groth ，Tamara J Blätte ，Cornelia Donow ，Sabrina Matysik ，Paul Walther ，Penelope A Jeggo ，Martin D Burkhalter ，Melanie Philipp

Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage

WDR4缺失导致的纤毛缺陷与蛋白酶体过度活跃和泛素缺乏有关。

Advanced Spray-Dried Inhalable Microparticles/Nanoparticles of an Innovative Mitophagy Activator for Targeted Lung Delivery: Design, Comprehensive Characterization, Human Lung Cell Culture, and In Vitro Aerosol Dispersion Performance

一种创新型线粒体自噬激活剂的先进喷雾干燥可吸入微粒/纳米颗粒靶向肺部递送：设计、全面表征、人肺细胞培养和体外气溶胶分散性能

Structure-Activity Relationship of Pyrrolidine Pentamine Derivatives as Inhibitors of the Aminoglycoside 6'- N-Acetyltransferase Type Ib

吡咯烷五胺衍生物作为氨基糖苷类 6'-N-乙酰转移酶 Ib 型抑制剂的构效关系

Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development

蛋白偶联受体激酶 4 在纤毛和肾脏发育过程中抑制 mTOR 信号传导不需要激酶活性

The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

三种化合物的平行构效关系筛选鉴定出吡咯烷双环胍类黑皮质素-3受体（MC3R）小分子配体的共同激动剂药效团

Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity

鉴定出可释放出传染性降低的减毒病毒的 SARS-CoV-2 刺突棕榈酰化抑制剂

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist

基于功能混合物的定位扫描可识别出具有纳摩尔级黑皮质素-4 受体效力并与内源性 AGRP(86-132) 拮抗剂等效效力的拮抗剂四肽序列 (LAtTeS) 库

Inhibition of Aminoglycoside 6'- N-acetyltransferase Type Ib (AAC(6')-Ib): Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors

氨基糖苷类 6'- N-乙酰转移酶 Ib 型 (AAC(6')-Ib) 的抑制：取代吡咯烷五胺衍生物作为抑制剂的构效关系

Nucleolar Stress Functions Upstream to Stimulate Expression of Autophagy Regulators

核仁应激作用于上游，刺激自噬调节剂的表达

Resting cells rely on the DNA helicase component MCM2 to build cilia

静止细胞依靠DNA解旋酶组分MCM2来构建纤毛。