日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A model for Crohn's disease post-ileal resection fibrosis development using human ileal enteroids and myofibroblasts

利用人回肠类器官和肌成纤维细胞构建克罗恩病回肠切除术后纤维化发展模型

期刊:Frontiers in Physiology
影响因子:3.4
doi:10.3389/fphys.2026.1764088
Yoo, Jun Hwan; Choi, Yoon Jeong; Pinchuk, Iryna V; Powell, Don W; Zachos, Nicholas C; Donowitz, Mark
成纤维细胞
细胞生物学
克罗恩病
3D/类器官
发表日期：2026
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Differential regulation of NHE3 expression in type 1 and type 2 diabetic intestine: impaired endosomal regulation of NHE3 expression in type 1 diabetes

1型和2型糖尿病肠道中NHE3表达的差异性调控：1型糖尿病中NHE3表达的内体调控受损

期刊:American Journal of Physiology-Cell Physiology
影响因子:4.7
doi:10.1152/ajpcell.00590.2025
Singh, Varsha; Lin, Ruxian; Sunuwar, Laxmi; Yang, Jianbo; Donowitz, Mark; Sarker, Rafiquel
糖尿病
信号转导
代谢
发表日期：2025
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Nherf2 is a major determinant of bile acid pool dynamics and contributes to regulation of Western diet-induced obesity

Nherf2是胆汁酸池动态变化的主要决定因素，并参与调节西方饮食诱导的肥胖。

期刊:American Journal of Physiology-Cell Physiology
影响因子:4.7
doi:10.1152/ajpcell.00716.2025
Dong, Dachuan; Shen, Wen-Jun; Bittner, Stefanie; Chen, Jia; Hao, Xiao; Donowitz, Mark; Kraemer, Fredric B; Azhar, Salman
肥胖
代谢
发表日期：2025
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Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide.

部分分化的回肠和远端结肠人类 F508del-囊性纤维化-肠类器官在福斯克林和利那洛肽的作用下分泌液体

期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2025.112453
Rong Yan, Zhang Zixin, de Jonge Hugo R, Lin Ruxian, Yu Huimin, Sarker Rafiq, Boffelli Dario, Zwick Rachel K, Klein Ophir D, Tse Chung-Ming, Donowitz Mark, Singh Varsha
其它
Human
3D/类器官
发表日期：2025
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Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids secrete fluid in response to forskolin and linaclotide

回肠和远端结肠人F508del-CF肠类器官中部分分化的肠细胞在福斯克林和利那洛肽刺激下分泌液体。

期刊:
影响因子:
doi:10.1101/2025.02.03.636268
Rong, Yan; Zhang, Zixin; de Jonge, Hugo R; Lin, Ruxian; Yu, Huimin; Sarker, Rafiq; Boffelli, Dario; Zwick, Rachel K; Klein, Ophir D; Tse, Ming; Donowitz, Mark; Singh, Varsha
细胞生物学
3D/类器官
发表日期：2025
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Differential Regulation of NHE3 Expression in Type 1 and Type 2 Diabetic Intestine: Impaired Endosomal Regulation of NHE3 Expression in Type 1 Diabetes

1型和2型糖尿病肠道中NHE3表达的差异性调控：1型糖尿病中NHE3表达的内体调控受损

期刊:
影响因子:
doi:10.1101/2025.09.10.675364
Singh, Varsha; Lin, Ruxian; Sunuwar, Laxmi; Yang, Jianbo; Donowitz, Mark; Sarker, Rafiquel
糖尿病
信号转导
代谢
发表日期：2025
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A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity

一种新型肽通过刺激钠氢交换器3的活性来阻止肠毒素和炎症诱导的肠液分泌。

期刊:Gastroenterology
影响因子:25.1
doi:10.1053/j.gastro.2023.06.028
Zachos, Nicholas C; Vaughan, Hannah; Sarker, Rafiquel; Est-Witte, Savannah; Chakraborty, Molee; Baetz, Nicholas W; Yu, Hongzhe; Yarov-Yarovoy, Vladimir; McNamara, George; Green, Jordan J; Tse, Chung-Ming; Donowitz, Mark
炎症/感染
Immunology/Inflammation
炎症
发表日期：2023
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Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2

法尼醇X受体增强上皮细胞ACE2表达并抑制病毒诱导的IL-6分泌：对SARS-CoV-2肠道症状的意义

期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology
影响因子:3.3
doi:10.1152/ajpgi.00099.2023
Smyth, Jessica S; Truong, Jennifer K; Rao, Anuradha; Lin, Ruxian; Foulke-Abel, Jennifer; Adorini, Luciano; Donowitz, Mark; Dawson, Paul A; Keely, Stephen J
SARS-CoV-2
上皮细胞
信号转导
微生物学
细胞生物学
IL-6
ACE2
发表日期：2023
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Has a physiologic function for NHE2 finally been identified?

NHE2的生理功能最终确定了吗？

期刊:Acta Physiologica
影响因子:5.6
doi:10.1111/apha.13792
Donowitz, Mark
发表日期：2022
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Patients' perspectives on the derivation and use of organoids

患者对类器官的获取和应用的看法

期刊:Stem Cell Reports
影响因子:5.1
doi:10.1016/j.stemcr.2021.07.004
Bollinger, Juli; May, Elizabeth; Mathews, Debra; Donowitz, Mark; Sugarman, Jeremy
3D/类器官
发表日期：2021
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